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Accession:CHEBI:85161 term browser browse the term
Definition:An organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
Synonyms:exact_synonym: (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one
 related_synonym: 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one;   Formula=C19H24N2O;   InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1;   InChIKey=CPZBLNMUGSZIPR-NVXWUHKLSA-N;   SMILES=O=C1N(C[C@H]2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2;   palonosetronum
 xref: CAS:135729-61-2 "ChemIDplus";   CAS:135729-61-2 "KEGG DRUG";   DrugBank:DB00377;   Drug_Central:2046 "DrugCentral";   HMDB:HMDB0014521;   KEGG:D07175;   LINCS:LSM-5266
 xref_mesh: MESH:C083418
 xref: PMID:23653153 "Europe PMC";   PMID:24129597 "Europe PMC";   PMID:24154700 "Europe PMC";   PMID:24280811 "Europe PMC";   PMID:24590374 "Europe PMC";   PMID:24604014 "Europe PMC";   PMID:24935579 "Europe PMC";   PMID:24947121 "Europe PMC";   PMID:25037960 "Europe PMC";   PMID:25063271 "Europe PMC";   PMID:25179689 "Europe PMC";   PMID:25360998 "Europe PMC";   PMID:25435944 "Europe PMC";   PMID:25533447 "Europe PMC";   Wikipedia:Palonosetron
 cyclic_relationship: is_conjugate_base_of CHEBI:85163

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palonosetron term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antiemetic 5091
              palonosetron 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                lactam 7814
                                                  delta-lactam 1196
                                                    palonosetron 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.