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Accession:CHEBI:85966 term browser browse the term
Definition:A member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Used (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure.
Synonyms:exact_synonym: 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one
 related_synonym: Formula=C27H36N2O5;   InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1;   InChIKey=ACRHBAYQBXXRTO-OAQYLSRUSA-N;   S-16257;   S-16257-2;   SMILES=COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC
 xref: CAS:155974-00-8 "ChemIDplus";   CAS:155974-00-8 "KEGG DRUG";   Drug_Central:3312 "DrugCentral";   KEGG:D07165
 xref_mesh: MESH:C088408
 xref: PMID:25158669 "Europe PMC";   PMID:25179314 "Europe PMC";   PMID:25240447 "Europe PMC";   PMID:25346368 "Europe PMC";   PMID:25350985 "Europe PMC";   PMID:25636072 "Europe PMC";   PMID:25656911 "Europe PMC";   PMID:25687888 "Europe PMC";   PMID:25700807 "Europe PMC";   PMID:25706659 "Europe PMC";   PMID:25733317 "Europe PMC";   PMID:25801408 "Europe PMC";   PMID:25809454 "Europe PMC";   PMID:25839989 "Europe PMC";   PMID:25911606 "Europe PMC";   PMID:25926678 "Europe PMC";   PMID:25953938 "Europe PMC";   PMID:25968495 "Europe PMC";   PMID:25982136 "Europe PMC";   PMID:25986146 "Europe PMC";   Reaxys:8366413 "Reaxys";   Wikipedia:Ivabradine
 cyclic_relationship: is_conjugate_base_of CHEBI:85972

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ivabradine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464

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  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            cardiovascular drug 7567
              cardiotonic drug 1952
                ivabradine 2
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  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        tertiary amino compound 8547
                                          ivabradine 2
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