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ONTOLOGY REPORT - ANNOTATIONS


Term:bohemine
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Accession:CHEBI:86007 term browser browse the term
Definition:Purine substituted on C-2, C-6 and N-9 with (3-hydroxypropyl)amino, benzylamino and isopropyl groups respectively; a synthetic, cell-permeable, cyclin-dependent kinase (CDK) inhibitor that is structurally similar to olomoucine and roscovitine.
Synonyms:exact_synonym: 3-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}propan-1-ol
 related_synonym: 2-[(3-hydroxypropyl)amino]-6-benzylamino-9-isopropylpurine;   3-{[6-(benzylamino)-9-isopropyl-9H-purin-2-yl]amino}propan-1-ol;   Formula=C18H24N6O;   InChI=1S/C18H24N6O/c1-13(2)24-12-21-15-16(20-11-14-7-4-3-5-8-14)22-18(23-17(15)24)19-9-6-10-25/h3-5,7-8,12-13,25H,6,9-11H2,1-2H3,(H2,19,20,22,23);   InChIKey=OPQGFIAVPSXOBO-UHFFFAOYSA-N;   SMILES=CC(C)n1cnc2c(NCc3ccccc3)nc(NCCCO)nc12
 xref_mesh: MESH:C118034
 xref: PMID:11181503 "Europe PMC";   PMID:12487731 "Europe PMC";   PMID:12667701 "Europe PMC";   PMID:19003322 "Europe PMC";   PMID:22250642 "Europe PMC";   PMID:24675180 "Europe PMC";   PMID:26024233 "Europe PMC";   Reaxys:8716256 "Reaxys"


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bohemine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      biological role 19694
        inhibitor 18167
          enzyme inhibitor 18089
            EC 2.* (transferase) inhibitor 13513
              EC 2.7.* (P-containing group transferase) inhibitor 13177
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8111
                  EC 2.7.11.22 (cyclin-dependent kinase) inhibitor 262
                    bohemine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic molecule 19434
                              organic cyclic compound 19203
                                organic heterocyclic compound 18272
                                  organic heteropolycyclic compound 17577
                                    organic heterobicyclic compound 16244
                                      imidazopyrimidine 5416
                                        purines 5414
                                          bohemine 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.