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ONTOLOGY REPORT - ANNOTATIONS


Term:conazole antifungal agent
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Accession:CHEBI:86323 term browser browse the term
Definition:A compound that has a structure that is related to miconazole, contains an azole (imidazole or triazole) moiety, and has significant systemic antifungal properties. They inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function.
Synonyms:related_synonym: azole antibiotic;   azole antibiotics;   conazole antifungal agents
 alt_id: CHEBI:60593


show annotations for term's descendants       view all columns           Sort by:
 
itraconazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB4 ATP binding cassette subfamily B member 4 JBrowse link 9 93,171,371 93,262,124 RGD:6480464
ketoconazole term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CYP3A29 cytochrome P450 3A29 JBrowse link 3 6,738,502 6,778,121 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 847
    role 824
      biological role 824
        antimicrobial agent 217
          antifungal agent 69
            conazole antifungal agent 2
              conazole antifungal drug + 2
              conazole fungicide + 0
              diniconazole-M + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 847
    subatomic particle 831
      composite particle 831
        hadron 831
          baryon 831
            nucleon 831
              atomic nucleus 831
                atom 831
                  main group element atom 819
                    p-block element atom 816
                      carbon group element atom 787
                        carbon atom 783
                          organic molecular entity 783
                            organic molecule 701
                              organic cyclic compound 621
                                organic heterocyclic compound 332
                                  heteroarene 88
                                    monocyclic heteroarene 20
                                      azole 20
                                        conazole antifungal agent 2
                                          conazole antifungal drug + 2
                                          conazole fungicide + 0
                                          diniconazole-M + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.