Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antifungal drug
go back to main search page
Accession:CHEBI:86327 term browser browse the term
Definition:Any antifungal agent used to prevent or treat fungal infections in humans or animals.
Synonyms:related_synonym: anti-fungal drug;   anti-fungal drugs;   anti-fungal medication;   anti-fungal medications;   antifungal drugs;   antifungal medication;   antifungal medications;   pharmaceutical fungicide;   pharmaceutical fungicides
 xref: Wikipedia:Antifungal


show annotations for term's descendants           Sort by:
 
amphotericin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions
increases expression
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein] CTD PMID:24105867 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions
increases expression
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:63,615,445...63,729,386
Ensembl chr 6:63,618,323...63,730,146
JBrowse link
G REN renin decreases secretion EXP Amphotericin B results in decreased secretion of REN protein CTD PMID:7391978 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G TNF tumor necrosis factor increases expression EXP Amphotericin B results in increased expression of TNF protein CTD PMID:24105867 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
clotrimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Clotrimazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects binding
increases activity
EXP Clotrimazole binds to NR1I3 protein
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form
CTD PMID:21778469, PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
JBrowse link
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Ibuprofen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ibuprofen results in increased expression of PTGS2 protein CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
multiple interactions
decreases activity
EXP Ketoconazole results in decreased expression of ABCB1 mRNA
[Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi
CTD PMID:19754906, PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G CYP3A12 cytochrome P-450 3A12 multiple interactions
decreases activity
EXP Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam]
Ketoconazole results in decreased activity of CYP3A12 protein
CTD PMID:15677349
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 221
    role 221
      application 189
        pharmaceutical 186
          drug 186
            antifungal drug 10
              10-undecenoic acid + 0
              Siccanin 0
              Tolciclate 0
              abafungin 0
              allylamine antifungal drug + 0
              antibiotic antifungal drug + 3
              benzofuran antifungal drug + 0
              bridged diphenyl antifungal drug + 0
              butenafine + 0
              butenafine hydrochloride 0
              candicidin D + 0
              chloroxine 0
              chlorphenesin + 0
              conazole antifungal drug + 4
              hydroxypyridone antifungal drug + 0
              imidazole antifungal drug + 4
              malachite green 0
              malachite green cation + 0
              morpholine antifungal drug + 0
              neticonazole 0
              neticonazole hydrochloride 0
              propionic acid + 3
              pyrimidine antifungal drug + 0
              pyrrolnitrin 0
              ravuconazole 0
              sodium propionate 0
              sodium thiosulfate + 0
              sodium thiosulfate pentahydrate 0
              thimerosal 0
              thiophanate 0
              tolnaftate 0
              triacetin 0
              triazole antifungal drug + 0
              trimetrexate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 221
    role 221
      application 189
        pharmaceutical 186
          drug 186
            antiinfective agent 75
              antifungal drug 10
                10-undecenoic acid + 0
                Siccanin 0
                Tolciclate 0
                abafungin 0
                allylamine antifungal drug + 0
                antibiotic antifungal drug + 3
                benzofuran antifungal drug + 0
                bridged diphenyl antifungal drug + 0
                butenafine + 0
                butenafine hydrochloride 0
                candicidin D + 0
                chloroxine 0
                chlorphenesin + 0
                conazole antifungal drug + 4
                hydroxypyridone antifungal drug + 0
                imidazole antifungal drug + 4
                malachite green 0
                malachite green cation + 0
                morpholine antifungal drug + 0
                neticonazole 0
                neticonazole hydrochloride 0
                propionic acid + 3
                pyrimidine antifungal drug + 0
                pyrrolnitrin 0
                ravuconazole 0
                sodium propionate 0
                sodium thiosulfate + 0
                sodium thiosulfate pentahydrate 0
                thimerosal 0
                thiophanate 0
                tolnaftate 0
                triacetin 0
                triazole antifungal drug + 0
                trimetrexate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.