Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antifungal drug
go back to main search page
Accession:CHEBI:86327 term browser browse the term
Definition:Any antifungal agent used to prevent or treat fungal infections in humans or animals.
Synonyms:related_synonym: anti-fungal drug;   anti-fungal drugs;   anti-fungal medication;   anti-fungal medications;   antifungal drugs;   antifungal medication;   antifungal medications;   pharmaceutical fungicide;   pharmaceutical fungicides
 xref: Wikipedia:Antifungal


show annotations for term's descendants           Sort by:
 
alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases uptake
multiple interactions
EXP INS protein results in increased uptake of 2-(methylamino)isobutyric acid
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD PMID:1928324 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
amphotericin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 increases expression
multiple interactions
EXP Amphotericin B results in increased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions
increases expression
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:129,520,397...129,636,207
Ensembl chr 6:129,519,962...129,635,517
JBrowse link
bezafibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 increases expression
increases secretion
EXP Bezafibrate results in increased expression of APOA1 mRNA
Bezafibrate results in increased secretion of APOA1 protein
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Bezafibrate results in increased expression of BCL2 CTD PMID:16316343 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:16316343 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein] CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP Bezafibrate results in decreased expression of LIPG mRNA; Bezafibrate results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,876
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein] CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization
increases expression
EXP Bezafibrate affects the localization of SCARB1 protein
Bezafibrate results in increased expression of SCARB1 mRNA
CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,565
JBrowse link
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression
multiple interactions
EXP Ibuprofen results in decreased expression of NOS3 mRNA
11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 11-deoxyprostaglandin E1 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]; sulprostone inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]
CTD PMID:10525081, PMID:10644584 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 3A29 multiple interactions EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link
sirolimus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXO1 forkhead box O1 increases expression
affects localization
EXP Sirolimus results in increased expression of FOXO1 mRNA; Sirolimus results in increased expression of FOXO1 protein
Sirolimus affects the localization of FOXO1 protein
CTD PMID:20622751 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473
JBrowse link
G IGF2 insulin like growth factor 2 decreases expression EXP Sirolimus results in decreased expression of IGF2 mRNA; Sirolimus results in decreased expression of IGF2 protein CTD PMID:20622751 NCBI chr 2:1,469,183...1,496,417 JBrowse link
G INS insulin multiple interactions
decreases expression
EXP Sirolimus inhibits the reaction [Glucose results in increased secretion of INS protein]
Sirolimus results in decreased expression of INS mRNA; Sirolimus results in decreased expression of INS protein
CTD PMID:20622751 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G NEUROD1 neuronal differentiation 1 decreases expression EXP Sirolimus results in decreased expression of NEUROD1 mRNA CTD PMID:20622751 NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,764...87,179,961
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 decreases expression EXP Sirolimus results in decreased expression of PDX1 mRNA CTD PMID:20622751 NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,639...5,310,843
JBrowse link
G SELP selectin P multiple interactions EXP Sirolimus inhibits the reaction [Zymosan analog results in increased expression of SELP protein] CTD PMID:16797888 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP Sirolimus inhibits the reaction [Zymosan analog results in increased expression of VCAM1 protein] CTD PMID:16797888 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 860
    role 838
      application 475
        pharmaceutical 420
          drug 420
            antifungal drug 20
              10-undecenoic acid + 0
              Siccanin 0
              Tolciclate 0
              abafungin 0
              allylamine antifungal drug + 0
              antibiotic antifungal drug + 9
              benzofuran antifungal drug + 0
              bridged diphenyl antifungal drug + 0
              butenafine + 0
              butenafine hydrochloride 0
              candicidin D + 0
              chloroxine 0
              chlorphenesin + 0
              conazole antifungal drug + 2
              hydroxypyridone antifungal drug + 0
              imidazole antifungal drug + 1
              malachite green 0
              malachite green cation + 0
              morpholine antifungal drug + 0
              neticonazole 0
              neticonazole hydrochloride 0
              propionic acid + 10
              pyrimidine antifungal drug + 0
              pyrrolnitrin 0
              ravuconazole 0
              sodium propionate 0
              sodium thiosulfate + 0
              sodium thiosulfate pentahydrate 0
              thimerosal 0
              thiophanate 0
              tolnaftate 0
              triacetin 0
              triazole antifungal drug + 1
              trimetrexate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 860
    role 838
      application 475
        pharmaceutical 420
          drug 420
            antiinfective agent 146
              antifungal drug 20
                10-undecenoic acid + 0
                Siccanin 0
                Tolciclate 0
                abafungin 0
                allylamine antifungal drug + 0
                antibiotic antifungal drug + 9
                benzofuran antifungal drug + 0
                bridged diphenyl antifungal drug + 0
                butenafine + 0
                butenafine hydrochloride 0
                candicidin D + 0
                chloroxine 0
                chlorphenesin + 0
                conazole antifungal drug + 2
                hydroxypyridone antifungal drug + 0
                imidazole antifungal drug + 1
                malachite green 0
                malachite green cation + 0
                morpholine antifungal drug + 0
                neticonazole 0
                neticonazole hydrochloride 0
                propionic acid + 10
                pyrimidine antifungal drug + 0
                pyrrolnitrin 0
                ravuconazole 0
                sodium propionate 0
                sodium thiosulfate + 0
                sodium thiosulfate pentahydrate 0
                thimerosal 0
                thiophanate 0
                tolnaftate 0
                triacetin 0
                triazole antifungal drug + 1
                trimetrexate 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.