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Accession:CHEBI:8654 term browser browse the term
Definition:A carboxamidine that is 1,4,5,6-tetrahydropyrimidine that is substituted at position 1 by a methyl group and at position 2 by an (E)-2-(2-thienyl)vinyl group. It is used, particularly as the embonate [4,4'-methylenebis(3-hydroxy-2-naphthoate)] salt, as an anthelmintic that is effective against intestinal nematodes including threadworms, roundworms and hookworms, and is included in the WHO 'Model List of Essential Medicines'.
Synonyms:exact_synonym: 1-methyl-2-[(E)-2-(2-thienyl)vinyl]-1,4,5,6-tetrahydropyrimidine
 related_synonym: Formula=C11H14N2S;   InChI=1S/C11H14N2S/c1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h2,4-6,9H,3,7-8H2,1H3/b6-5+;   InChIKey=YSAUAVHXTIETRK-AATRIKPKSA-N;   SMILES=CN1CCCN=C1\\C=C\\c1cccs1;   pirantel;   pyrantelum
 xref: CAS:15686-83-6 "ChemIDplus";   CAS:15686-83-6 "KEGG COMPOUND";   Drug_Central:2999 "DrugCentral";   KEGG:C07409;   KEGG:D08451
 xref_mesh: MESH:D011715
 xref: PMID:20307935 "Europe PMC";   PMID:21689886 "Europe PMC";   PMID:2619378 "Europe PMC";   PMID:5124439 "Europe PMC";   PMID:552733 "Europe PMC";   PMID:7402460 "Europe PMC";   Patent:BE658987;   Patent:US3502661;   Reaxys:518505 "Reaxys";   Wikipedia:Pyrantel

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pyrantel term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      application 19347
        pesticide 16147
          nematicide 3301
            antinematodal drug 450
              pyrantel 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic molecule 19434
                              organic cyclic compound 19203
                                organic heterocyclic compound 18272
                                  organonitrogen heterocyclic compound 17193
                                    tetrahydropyrimidine 1
                                      1,4,5,6-tetrahydropyrimidines 1
                                        pyrantel 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.