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ONTOLOGY REPORT - ANNOTATIONS


Term:stattic
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Accession:CHEBI:86989 term browser browse the term
Definition:A member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma.
Synonyms:exact_synonym: 6-nitro-1H-1-benzothiophene-1,1-dione
 related_synonym: 6-nitro-1-benzothiophene 1,1-dioxide;   CHEMBL1337170;   Formula=C8H5NO4S;   InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H;   InChIKey=ZRRGOUHITGRLBA-UHFFFAOYSA-N;   SMILES=[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1;   STAT3 Inhibitor V
 xref_mesh: MESH:C517409
 xref: PMID:17114005 "Europe PMC";   PMID:25425624 "Europe PMC";   PMID:25492480 "Europe PMC";   Reaxys:11410 "Reaxys"


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stattic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:6480464
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cish cytokine inducible SH2-containing protein JBrowse link 8 116,054,547 116,059,494 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6480464
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6480464
G Mir21 microRNA 21 JBrowse link 10 73,902,210 73,902,301 RGD:6480464
G Mmp10 matrix metallopeptidase 10 JBrowse link 8 5,734,348 5,742,243 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Psmb1 proteasome 20S subunit beta 1 JBrowse link 1 57,470,878 57,491,359 RGD:6480464
G Psmb2 proteasome 20S subunit beta 2 JBrowse link 5 144,702,004 144,734,220 RGD:6480464
G Psmb3 proteasome 20S subunit beta 3 JBrowse link 10 85,646,646 85,653,729 RGD:6480464
G Psmb4 proteasome 20S subunit beta 4 JBrowse link 2 196,043,546 196,046,320 RGD:6480464
G Psmb5 proteasome 20S subunit beta 5 JBrowse link 15 33,259,039 33,263,634 RGD:6480464
G Psmb6 proteasome 20S subunit beta 6 JBrowse link 10 57,131,339 57,133,685 RGD:6480464
G Psmb7 proteasome 20S subunit beta 7 JBrowse link 3 22,890,072 22,951,718 RGD:6480464
G Riox2 ribosomal oxygenase 2 JBrowse link 11 43,006,190 43,028,722 RGD:6480464
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        inhibitor 18143
          STAT3 inhibitor 35
            stattic 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                organic heterocyclic compound 18245
                                  organic heteropolycyclic compound 17500
                                    organic heterobicyclic compound 15910
                                      benzothiophenes 901
                                        1-benzothiophenes 901
                                          stattic 35
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.