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ONTOLOGY REPORT - ANNOTATIONS


Term:PF-670462
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Accession:CHEBI:87236 term browser browse the term
Definition:A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selective inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).
Synonyms:exact_synonym: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
 related_synonym: Formula=C19H22Cl2FN5;   InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H;   InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N;   SMILES=Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
 xref: CAS:950912-80-8 "ChemIDplus"
 xref_mesh: MESH:C522839
 xref: PMID:17502429 "Europe PMC";   PMID:20407760 "Europe PMC";   PMID:21927596 "Europe PMC";   PMID:22168824 "Europe PMC";   PMID:22549116 "Europe PMC";   PMID:22743604 "Europe PMC";   PMID:22832921 "Europe PMC";   PMID:23349822 "Europe PMC";   PMID:23863866 "Europe PMC";   PMID:23936135 "Europe PMC";   PMID:24076244 "Europe PMC";   PMID:25245819 "Europe PMC";   Reaxys:11152377 "Reaxys"


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PF-670462 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      biological role 19700
        biochemical role 19201
          cofactor 15454
            ammonium 8225
              ammonium ion derivative 8220
                PF-670462 free base(2+) 1
                  PF-670462 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    p-block element atom 19637
                      halogen 17901
                        chlorine atom 17668
                          chlorine molecular entity 17668
                            elemental chlorine 8386
                              monoatomic chlorine 8367
                                chloride 8367
                                  chloride salt 8367
                                    organic chloride salt 655
                                      hydrochloride 427
                                        PF-670462 1
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