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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mycophenolate mofetil
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Accession:CHEBI:8764 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation between the carboxylic acid group of mycophenolic acid and the hydroxy group of 2-(morpholin-4-yl)ethanol. In the liver, it is metabolised to mycophenolic acid, an immunosuppressant for which it is a prodrug. It is widely used to prevent tissue rejection following organ transplants as well as for the treatment of certain autoimmune diseases.
Synonyms:exact_synonym: 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
 related_synonym: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate;   Cellcept;   Formula=C23H31NO7;   InChI=1S/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3/b15-4+;   InChIKey=RTGDFNSFWBGLEC-SYZQJQIISA-N;   MMF;   RS 61443;   SMILES=COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(=O)OCCN1CCOCC1;   mycophenolic acid morpholinoethyl ester
 xref: CAS:128794-94-5;   DrugBank:DB00688;   Drug_Central:1859;   HMDB:HMDB0014826;   KEGG:C07908;   KEGG:D00752
 xref_mesh: MESH:C063008
 xref: PMID:11099793;   PMID:11490743;   PMID:15572389;   PMID:15992049;   PMID:16979992;   PMID:19858585;   PMID:21180633;   PMID:21710356;   PMID:22081165;   PMID:22294686;   PMID:22310598;   PMID:22417996;   PMID:22460418;   PMID:22560143;   PMID:8826401;   PMID:9274835;   Reaxys:7500599;   Wikipedia:Mycophenolate_mofetil


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mycophenolate mofetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Mycophenolate mofetil inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          mycophenolic acid 108
            mycophenolate mofetil 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            unsaturated fatty acid 922
                                              monounsaturated fatty acid 420
                                                hexenoic acid 108
                                                  hex-4-enoic acid 108
                                                    mycophenolic acid 108
                                                      mycophenolate mofetil 1
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