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ONTOLOGY REPORT - ANNOTATIONS


Term:ramipril
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Accession:CHEBI:8774 term browser browse the term
Definition:A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
Synonyms:exact_synonym: (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
 related_synonym: (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid;   Altace (TN);   Formula=C23H32N2O5;   InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1;   InChIKey=HDACQVRGBOVJII-JBDAPHQKSA-N;   Ramiprilum;   SMILES=CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1[C@H]2CCC[C@H]2C[C@H]1C(O)=O;   Tritace
 xref: Beilstein:4214464 "Beilstein";   CAS:87333-19-5 "ChemIDplus";   CAS:87333-19-5 "KEGG DRUG";   DrugBank:DB00178;   Drug_Central:2356 "DrugCentral";   HMDB:HMDB0014324;   KEGG:D00421;   LINCS:LSM-5950
 xref_mesh: MESH:D017257
 xref: PMID:11095026 "Europe PMC";   PMID:11575208 "Europe PMC";   PMID:12076194 "Europe PMC";   PMID:12768220 "Europe PMC";   PMID:15110900 "Europe PMC";   PMID:16144510 "Europe PMC";   PMID:16734081 "Europe PMC";   PMID:17004100 "Europe PMC";   PMID:17192135 "Europe PMC";   PMID:17496463 "Europe PMC";   PMID:17903031 "Europe PMC";   PMID:20122169 "Europe PMC";   PMID:22799880 "Europe PMC";   PMID:23557551 "Europe PMC";   PMID:23713675 "Europe PMC";   PMID:23747952 "Europe PMC";   PMID:23842688 "Europe PMC";   PMID:23842829 "Europe PMC";   PMID:23951921 "Europe PMC";   PMID:24048485 "Europe PMC";   PMID:24090393 "Europe PMC";   PMID:24191305 "Europe PMC";   PMID:24397981 "Europe PMC";   PMID:24435506 "Europe PMC";   PMID:24452090 "Europe PMC";   PMID:24509355 "Europe PMC";   Reaxys:4214464 "Reaxys";   VSDB:1888;   Wikipedia:Ramipril


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ramipril term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bmp7 bone morphogenetic protein 7 JBrowse link 3 170,879,972 170,955,820 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:6480464
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:6480464
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Myh7 myosin heavy chain 7 JBrowse link 15 33,605,769 33,657,761 RGD:6480464
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:6480464
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6480464
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Slc15a1 solute carrier family 15 member 1 JBrowse link 15 106,800,081 106,844,668 RGD:6480464
G Slc15a2 solute carrier family 15 member 2 JBrowse link 11 66,932,664 66,961,708 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Timp4 TIMP metallopeptidase inhibitor 4 JBrowse link 4 147,156,948 147,163,467 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pro-agent 8807
          prodrug 8597
            ramipril 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                peptide 9316
                                                  oligopeptide 1075
                                                    dipeptide 255
                                                      ramipril 25
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.