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Term:4,6-dioxoheptanoic acid
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Accession:CHEBI:87897 term browser browse the term
Definition:A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.
Synonyms:related_synonym: Formula=C7H10O4;   InChI=1S/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11);   InChIKey=WYEPBHZLDUPIOD-UHFFFAOYSA-N;   SMILES=CC(CC(CCC(O)=O)=O)=O;   succinylacetone
 alt_id: CHEBI:45625
 xref: CAS:51568-18-4 "ChemIDplus";   HMDB:HMDB0000635
 xref_mesh: MESH:C020804
 xref: PDBeChem:SHU;   PMID:10073910 "Europe PMC";   PMID:12052898 "Europe PMC";   PMID:16414314 "Europe PMC";   PMID:16448836 "Europe PMC";   PMID:17133337 "Europe PMC";   PMID:20351174 "Europe PMC";   PMID:22455637 "Europe PMC";   PMID:22456946 "Europe PMC";   PMID:22521492 "Europe PMC";   PMID:22906829 "Europe PMC";   PMID:25066104 "Europe PMC";   PMID:2889780 "Europe PMC";   Patent:US2011201539;   Reaxys:2436097 "Reaxys"

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4,6-dioxoheptanoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alas1 5'-aminolevulinate synthase 1 JBrowse link 8 114,927,704 114,941,038 RGD:6480464
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        biochemical role 19179
          metabolite 19151
            eukaryotic metabolite 18770
              animal metabolite 18511
                mammalian metabolite 18493
                  human metabolite 18133
                    4,6-dioxoheptanoic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        monocarboxylic acid 17260
                                          oxo monocarboxylic acid 6255
                                            dioxo monocarboxylic acid 1916
                                              4,6-dioxoheptanoic acid 5
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.