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ONTOLOGY REPORT - ANNOTATIONS


Term:CD437
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Accession:CHEBI:88334 term browser browse the term
Definition:A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)gamma and induces cell cycle arrest and apoptosis in various cancer cells.
Synonyms:exact_synonym: 6-(3-adamantan-1-yl-4-hydroxyphenyl)naphthalene-2-carboxylic acid
 related_synonym: 6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]-2-naphthalenecarboxylic acid;   6-[4-hydroxy-3-(tricyclo[3.3.1.1(3,7)]dec-1-yl)phenyl]naphthalene-2-carboxylic acid;   AHPN;   Apoptosis Activator VI;   CD-437;   Formula=C27H26O3;   InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30);   InChIKey=LDGIHZJOIQSHPB-UHFFFAOYSA-N;   SMILES=C1C2(CC3CC(CC1C3)C2)C4=C(C=CC(=C4)C5=CC=C6C(=C5)C=CC(=C6)C(=O)O)O
 xref: CAS:125316-60-1 "ChemIDplus";   LINCS:LSM-6237;   PMID:10942519 "Europe PMC";   PMID:11526443 "Europe PMC";   PMID:12566985 "Europe PMC";   PMID:12581872 "Europe PMC";   PMID:17474084 "Europe PMC";   PMID:18936944 "Europe PMC";   PMID:22446330 "Europe PMC";   PMID:9846184 "Europe PMC";   Reaxys:7445028 "Reaxys"


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adapalene term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd1d1 CD1d1 molecule JBrowse link 2 186,330,298 186,333,805 RGD:6480464
G Crabp2 cellular retinoic acid binding protein 2 JBrowse link 2 187,322,416 187,326,794 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        biochemical role 19179
          apoptosis inducer 10830
            CD437 6
              adapalene 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic group 18407
                              organic divalent group 18397
                                organodiyl group 18397
                                  carbonyl group 18285
                                    carbonyl compound 18285
                                      carboxylic acid 17940
                                        aromatic carboxylic acid 10745
                                          naphthoic acid 43
                                            CD437 6
                                              adapalene 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.