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ONTOLOGY REPORT - ANNOTATIONS


Term:bryostatin 1
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Accession:CHEBI:88353 term browser browse the term
Definition:A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.
Synonyms:exact_synonym: (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1(3,7).1(11,15)]nonacos-8-en-12-yl (2E,4E)-octa-2,4-dienoate
 related_synonym: Formula=C47H68O17;   InChI=1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1;   InChIKey=MJQUEDHRCUIRLF-TVIXENOKSA-N;   SMILES=C/1(\\C[C@H]2O[C@@H](C1)C[C@]3(C([C@H](C[C@@H](C[C@H](CC(O[C@@H]([C@@H](C)O)C[C@@]4(C\\C(\\[C@@H]([C@](C(C=C2)(C)C)(O4)O)OC(/C=C/C=C/CCC)=O)=C/C(OC)=O)[H])=O)O)O3)OC(C)=O)(C)C)O)=C\\C(OC)=O
 xref: CAS:83314-01-6 "ChemIDplus";   CAS:83314-01-6 "KEGG COMPOUND";   DrugBank:DB11752;   KEGG:C05149;   KNApSAcK:C00038654
 xref_mesh: MESH:C046785
 xref: PMID:10502742 "Europe PMC";   PMID:14735696 "Europe PMC";   PMID:16834754 "Europe PMC";   PMID:20354984 "Europe PMC";   PMID:21175177 "Europe PMC";   PMID:22539107 "Europe PMC";   PMID:22579485 "Europe PMC";   PMID:22986161 "Europe PMC";   PMID:23146662 "Europe PMC";   PMID:23369356 "Europe PMC";   PMID:24291721 "Europe PMC";   PMID:24659806 "Europe PMC";   PMID:24674872 "Europe PMC";   PMID:24677503 "Europe PMC";   PMID:25299527 "Europe PMC";   PMID:25301233 "Europe PMC";   PMID:25472878 "Europe PMC";   PMID:25523423 "Europe PMC";   PMID:25808573 "Europe PMC";   PMID:26225566 "Europe PMC";   PMID:26563568 "Europe PMC";   PMID:26891037 "Europe PMC";   PMID:27068183 "Europe PMC";   PMID:27128726 "Europe PMC";   PMID:27472877 "Europe PMC";   PMID:27941949 "Europe PMC";   PMID:27994072 "Europe PMC";   PMID:28467486 "Europe PMC";   PMID:28472666 "Europe PMC";   PMID:28482641 "Europe PMC";   PMID:28539614 "Europe PMC";   PMID:28590053 "Europe PMC";   PMID:28934369 "Europe PMC";   PMID:29026042 "Europe PMC";   PMID:29066536 "Europe PMC";   PMID:29115558 "Europe PMC";   PMID:8477194 "Europe PMC";   PMID:9195893 "Europe PMC";   PMID:9225066 "Europe PMC";   Reaxys:4349157 "Reaxys";   Wikipedia:Bryostatin


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bryostatin 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Cd22 CD22 molecule JBrowse link 1 89,313,475 89,329,902 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6480464
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6480464
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        fuel 10294
          methanol 2948
            methyl ester 2939
              bryostatin 1 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic ester 13967
                                        lactone 5864
                                          macrocyclic lactone 1518
                                            macrolide 1457
                                              bryostatins 10
                                                bryostatin 1 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.