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ONTOLOGY REPORT - ANNOTATIONS


Term:rivastigmine
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Accession:CHEBI:8874 term browser browse the term
Definition:A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
 related_synonym: (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate;   Formula=C14H22N2O2;   InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1;   InChIKey=XSVMFMHYUFZWBK-NSHDSACASA-N;   SMILES=CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C;   m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
 xref: CAS:123441-03-2 "ChemIDplus";   CAS:123441-03-2 "KEGG COMPOUND";   DrugBank:DB00989;   Drug_Central:2392 "DrugCentral";   KEGG:C11766;   KEGG:D03822;   LINCS:LSM-5280
 xref_mesh: MESH:C072506
 xref: PMID:19032006 "Europe PMC";   PMID:19370562 "Europe PMC";   PMID:19392927 "Europe PMC";   PMID:19619073 "Europe PMC";   PMID:19893314 "Europe PMC";   PMID:20070789 "Europe PMC";   PMID:20370805 "Europe PMC";   PMID:20865460 "Europe PMC";   PMID:21131668 "Europe PMC";   PMID:21246897 "Europe PMC";   PMID:21977379 "Europe PMC";   PMID:21996001 "Europe PMC";   PMID:22009228 "Europe PMC";   PMID:22010358 "Europe PMC";   PMID:22044027 "Europe PMC";   PMID:22054233 "Europe PMC";   PMID:22068922 "Europe PMC";   PMID:22087207 "Europe PMC";   PMID:22163241 "Europe PMC";   PMID:22163242 "Europe PMC";   PMID:22163243 "Europe PMC";   PMID:22173266 "Europe PMC";   PMID:22195801 "Europe PMC";   PMID:22224039 "Europe PMC";   PMID:22230648 "Europe PMC";   PMID:22230878 "Europe PMC";   PMID:22290743 "Europe PMC";   PMID:22362231 "Europe PMC";   PMID:22409834 "Europe PMC";   PMID:22451057 "Europe PMC";   Patent:DE3805744;   Patent:EP1980552;   Patent:EP2233465;   Patent:US2008255383;   Patent:US2009298817;   Patent:US5602176;   Reaxys:7875788 "Reaxys";   Wikipedia:Rivastigmine
 cyclic_relationship: is_conjugate_base_of CHEBI:64363


show annotations for term's descendants       view all columns           Sort by:
 
rivastigmine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:6480464
G Bche butyrylcholinesterase JBrowse link 2 171,104,476 171,196,186 RGD:6480464
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:6480464
G Ces2h carboxylesterase 2H JBrowse link 19 37,052,555 37,067,176 RGD:6480464
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:6480464
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:6480464
G Hsf1 heat shock transcription factor 1 JBrowse link 7 117,538,523 117,565,478 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        pharmacological role 18798
          neurotransmitter agent 16401
            cholinergic drug 4244
              rivastigmine 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic ester 13967
                                        carbamate ester 7335
                                          rivastigmine 10
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