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ONTOLOGY REPORT - ANNOTATIONS


Term:SC-58125
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Accession:CHEBI:8983 term browser browse the term
Definition:A member of the class of pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor, it exhibits anticancer property.
Synonyms:exact_synonym: 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole
 related_synonym: 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole;   Formula=C17H12F4N2O2S;   InChI=1S/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3;   InChIKey=JHBIMJKLBUMNAU-UHFFFAOYSA-N;   SMILES=CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F
 xref: CAS:162054-19-5 "ChemIDplus";   CAS:162054-19-5 "KEGG COMPOUND";   KEGG:C11705;   LINCS:LSM-6646
 xref_mesh: MESH:C090859
 xref: PMID:11218076 "Europe PMC";   PMID:11687954 "Europe PMC";   PMID:16116973 "Europe PMC";   Reaxys:7391749 "Reaxys"


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SC-58125 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19745
    role 19692
      application 19347
        pharmaceutical 19220
          drug 19220
            antineoplastic agent 16886
              SC-58125 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19745
    subatomic particle 19741
      composite particle 19741
        hadron 19741
          baryon 19741
            nucleon 19741
              atomic nucleus 19741
                atom 19741
                  main group element atom 19625
                    p-block element atom 19625
                      carbon group element atom 19519
                        carbon atom 19513
                          organic molecular entity 19513
                            organic molecule 19431
                              organic cyclic compound 19199
                                organic heterocyclic compound 18268
                                  heteroarene 15812
                                    monocyclic heteroarene 13130
                                      azole 12258
                                        diazole 8077
                                          pyrazoles 1200
                                            SC-58125 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.