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ONTOLOGY REPORT - ANNOTATIONS


Term:salsalate
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Accession:CHEBI:9014 term browser browse the term
Definition:A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.
Synonyms:exact_synonym: 2-[(2-hydroxybenzoyl)oxy]benzoic acid
 related_synonym: 2-Carboxyphenyl salicylate;   Disalcid;   Disalicylic acid;   Disalicylsaeure;   Formula=C14H10O5;   InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17);   InChIKey=WVYADZUPLLSGPU-UHFFFAOYSA-N;   O-Salicylcylsalicylsaeure;   SMILES=OC(=O)c1ccccc1OC(=O)c1ccccc1O;   Salicylic acid bimolecular ester;   Salicyloxysalicylic acid;   Salicyloylsalicylic acid;   Sasapyrin;   Sasapyrine;   Sasapyrinum;   o-Salicylsalicylic acid;   salicylsalicylic acid;   salsalato;   salsalatum
 xref: CAS:552-94-3 "ChemIDplus";   CAS:552-94-3 "KEGG DRUG";   CAS:552-94-3 "NIST Chemistry WebBook";   DrugBank:DB01399;   Drug_Central:2420 "DrugCentral";   KEGG:D00428
 xref_mesh: MESH:C014182
 xref: PMID:19747808 "Europe PMC";   PMID:20613460 "Europe PMC";   PMID:20876710 "Europe PMC";   PMID:21289240 "Europe PMC";   PMID:21519323 "Europe PMC";   PMID:21617098 "Europe PMC";   PMID:21764223 "Europe PMC";   PMID:21903749 "Europe PMC";   PMID:21938543 "Europe PMC";   PMID:22357964 "Europe PMC";   PMID:22388922 "Europe PMC";   PMID:22517326 "Europe PMC";   PMID:22782506 "Europe PMC";   PMID:22784842 "Europe PMC";   PMID:23370525 "Europe PMC";   PMID:23680037 "Europe PMC";   PMID:23801715 "Europe PMC";   PMID:23817699 "Europe PMC";   PMID:23817718 "Europe PMC";   PMID:23825542 "Europe PMC";   PMID:23871515 "Europe PMC";   PMID:23948064 "Europe PMC";   PMID:24130358 "Europe PMC";   PMID:28166217 "Europe PMC";   Reaxys:2590908 "Reaxys";   Wikipedia:Salsalate


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salsalate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pro-agent 8802
          prodrug 8592
            salsalate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic group 18423
                              organic divalent group 18414
                                organodiyl group 18414
                                  carbonyl group 18301
                                    carbonyl compound 18301
                                      carboxylic acid 17966
                                        aromatic carboxylic acid 10724
                                          benzoic acids 10690
                                            benzoic acid 3481
                                              hydroxybenzoic acid 2854
                                                monohydroxybenzoic acid 835
                                                  salicylic acid 743
                                                    salsalate 5
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