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ONTOLOGY REPORT - ANNOTATIONS


Term:tacedinaline
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Accession:CHEBI:90195 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Synonyms:exact_synonym: 4-acetamido-N-(2-aminophenyl)benzamide
 related_synonym: 4-(Acetylamino)-N-(2-aminophenyl)benzamide;   Acetyldinaline;   C.I. 994;   CI 994;   Formula=C15H15N3O2;   InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20);   InChIKey=VAZAPHZUAVEOMC-UHFFFAOYSA-N;   N-acetyldinaline;   SMILES=C1=C(C=CC(=C1)C(NC2=C(C=CC=C2)N)=O)NC(C)=O;   tacedinalina
 xref: CAS:112522-64-2 "ChemIDplus";   CAS:112522-64-2 "KEGG COMPOUND";   KEGG:D05988;   LINCS:LSM-19036
 xref_mesh: MESH:C081895
 xref: PMID:25827403 "Europe PMC";   PMID:26365427 "SUBMITTER";   Reaxys:8422586 "Reaxys"


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tacedinaline term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19749
    role 19696
      chemical role 19209
        environmental contaminant 18533
          benzene 5453
            1,2-phenylenediamine 2529
              tacedinaline 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19749
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19630
                    p-block element atom 19630
                      carbon group element atom 19523
                        carbon atom 19517
                          organic molecular entity 19517
                            organic group 18427
                              organic divalent group 18418
                                organodiyl group 18418
                                  carbonyl group 18305
                                    carbonyl compound 18305
                                      carboxylic acid 17972
                                        carboacyl group 17080
                                          univalent carboacyl group 17080
                                            carbamoyl group 16809
                                              carboxamide 16809
                                                monocarboxylic acid amide 14167
                                                  arenecarboxamide 6487
                                                    benzamides 6487
                                                      tacedinaline 1
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