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ONTOLOGY REPORT - ANNOTATIONS


Term:selumetinib
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Accession:CHEBI:90227 term browser browse the term
Definition:A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor.
Synonyms:exact_synonym: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
 related_synonym: ARRY 142886;   ARRY142886;   AZD 6244;   AZD6244;   Formula=C17H15BrClFN4O3;   InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26);   InChIKey=CYOHGALHFOKKQC-UHFFFAOYSA-N;   SMILES=N1(C=NC2=C1C=C(C(=C2F)NC3=CC=C(C=C3Cl)Br)C(=O)NOCCO)C;   selumetinibum
 alt_id: MESH:C517975
 xref: CAS:606143-52-6 "ChemIDplus";   KEGG:D09666;   LINCS:LSM-1056
 xref_mesh: MESH:C517975
 xref: PDBeChem:3EW;   PMID:20407895 "Europe PMC";   PMID:20978926 "Europe PMC";   PMID:21594619 "Europe PMC";   PMID:22241789 "Europe PMC";   PMID:22343622 "Europe PMC";   PMID:22394161 "Europe PMC";   PMID:22565394 "Europe PMC";   PMID:22972589 "Europe PMC";   PMID:23372439 "Europe PMC";   PMID:23444215 "Europe PMC";   PMID:23942066 "Europe PMC";   PMID:25322874 "Europe PMC";   PMID:25342139 "Europe PMC";   PMID:25379021 "Europe PMC";   PMID:25385055 "Europe PMC";   PMID:25498501 "Europe PMC";   PMID:25637165 "Europe PMC";   PMID:25887099 "Europe PMC";   PMID:26059332 "Europe PMC";   PMID:26384399 "Europe PMC";   PMID:26446942 "Europe PMC";   Reaxys:11099648 "Reaxys";   Wikipedia:Selumetinib


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selumetinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Camp cathelicidin antimicrobial peptide JBrowse link 8 117,930,557 117,932,371 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Chd4 chromodomain helicase DNA binding protein 4 JBrowse link 4 157,612,531 157,645,660 RGD:6480464
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 16 68,954,860 68,968,248 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Rps6ka1 ribosomal protein S6 kinase A1 JBrowse link 5 152,078,217 152,122,684 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      application 19361
        pharmaceutical 19230
          drug 19230
            antineoplastic agent 16893
              selumetinib 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            organic group 18432
                              organic divalent group 18423
                                organodiyl group 18423
                                  carbonyl group 18311
                                    carbonyl compound 18311
                                      carboxylic acid 17976
                                        carboacyl group 17082
                                          univalent carboacyl group 17082
                                            carbamoyl group 16810
                                              carboxamide 16810
                                                hydroxamic acid 6252
                                                  hydroxamic acid ester 128
                                                    selumetinib 20
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.