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ONTOLOGY REPORT - ANNOTATIONS


Term:vatalanib
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Accession:CHEBI:90620 term browser browse the term
Definition:A member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.
Synonyms:exact_synonym: N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
 related_synonym: CGP-79787;   CGP79787;   Formula=C20H15ClN4;   InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25);   InChIKey=YCOYDOIWSSHVCK-UHFFFAOYSA-N;   N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine;   N-(p-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;   PTK-787;   PTK/ZK;   PTK787;   SMILES=N1=NC(=C2C(=C1CC=3C=CN=CC3)C=CC=C2)NC4=CC=C(C=C4)Cl;   ZK-232934
 xref: CAS:212141-54-3 "ChemIDplus";   DrugBank:DB04879;   KEGG:D06285;   LINCS:LSM-5774
 xref_mesh: MESH:C404768
 xref: PMID:16882767 "Europe PMC";   PMID:21617019 "Europe PMC";   PMID:22197613 "Europe PMC";   PMID:22664478 "Europe PMC";   PMID:22910317 "Europe PMC";   PMID:23488610 "Europe PMC";   PMID:23700288 "Europe PMC";   PMID:24449400 "Europe PMC";   PMID:24799063 "Europe PMC";   PMID:24838014 "Europe PMC";   PMID:24939212 "Europe PMC";   PMID:25340839 "Europe PMC";   PMID:26206183 "Europe PMC";   PMID:26403354 "Europe PMC";   Reaxys:8638800 "Reaxys";   Wikipedia:Vatalanib


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vatalanib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19754
    role 19701
      application 19353
        pharmaceutical 19222
          drug 19222
            antineoplastic agent 16903
              vatalanib 2
                vatalanib succinate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19754
    subatomic particle 19752
      composite particle 19752
        hadron 19752
          baryon 19752
            nucleon 19752
              atomic nucleus 19752
                atom 19752
                  main group element atom 19637
                    main group molecular entity 19637
                      s-block molecular entity 19397
                        hydrogen molecular entity 19386
                          hydrides 18356
                            inorganic hydride 17216
                              pnictogen hydride 17180
                                nitrogen hydride 17014
                                  azane 16706
                                    ammonia 16703
                                      organic amino compound 16702
                                        secondary amino compound 6390
                                          vatalanib 2
                                            vatalanib succinate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.