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ONTOLOGY REPORT - ANNOTATIONS


Term:U0126
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Accession:CHEBI:90693 term browser browse the term
Definition:An aryl sulfide that is (2Z,3Z)-bis[amino(sulfanyl)methylidene]butanedinitrile in which the sulfanyl hydrogens are replaced by 2-aminophenyl groups. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties.
Synonyms:exact_synonym: (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile
 related_synonym: FT-1069-1;   Formula=C18H16N6S2;   InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+;   InChIKey=DVEXZJFMOKTQEZ-JYFOCSDGSA-N;   SMILES=C=1(C=CC=CC1N)S/C(=C(/C(/C#N)=C(/SC=2C(=CC=CC2)N)\\N)\\C#N)/N;   U 0126
 alt_id: CHEBI:64208
 xref: CAS:109511-58-2 "ChemIDplus";   CAS:218601-62-8 "ChemIDplus";   LINCS:LSM-42806;   PDBeChem:5BM;   PMID:21618303 "Europe PMC";   PMID:22025280 "Europe PMC";   PMID:22052387 "Europe PMC";   PMID:22075021 "Europe PMC";   PMID:22101421 "Europe PMC";   PMID:22129618 "Europe PMC";   PMID:22182511 "Europe PMC";   PMID:22273495 "Europe PMC";   PMID:22286127 "Europe PMC";   PMID:22301382 "Europe PMC";   PMID:22313325 "Europe PMC";   PMID:22354777 "Europe PMC";   PMID:22396328 "Europe PMC";   PMID:24947959 "Europe PMC";   PMID:25363751 "Europe PMC";   PMID:25407271 "Europe PMC";   PMID:25492115 "Europe PMC";   PMID:25544156 "Europe PMC";   PMID:26349244 "Europe PMC";   PMID:9660836 "Europe PMC";   Reaxys:3483750 "Reaxys";   Wikipedia:U0126


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U0126 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:15090804

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      chemical role 19197
        antioxidant 14130
          U0126 1
            U0126.EtOH 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    main group molecular entity 19614
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18289
                            inorganic hydride 17210
                              pnictogen hydride 17172
                                nitrogen hydride 17008
                                  azane 16699
                                    ammonia 16696
                                      organic amino compound 16695
                                        aromatic amine 13604
                                          anilines 12310
                                            substituted aniline 11806
                                              U0126 1
                                                U0126.EtOH 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.