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ONTOLOGY REPORT - ANNOTATIONS


Term:cangrelor
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Accession:CHEBI:90841 term browser browse the term
Definition:A nucleoside triphosphate analogue that is 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]adenosine carrying additional 2-(methylsulfanyl)ethyl and (3,3,3-trifluoropropyl)sulfanyl substituents at positions N6 and C2 respectively. Used (in the form of its tetrasodium salt) as an intravenous antiplatelet drug that prevents formation of harmful blood clots in the coronary arteries.
Synonyms:exact_synonym: 5'-O-[({[dichloro(phosphono)methyl](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]-N-[2-(methylsulfanyl)ethyl]-2-[(3,3,3-trifluoropropyl)sulfanyl]adenosine
 related_synonym: Formula=C17H25Cl2F3N5O12P3S2;   InChI=1S/C17H25Cl2F3N5O12P3S2/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32)/t8-,10-,11-,14-/m1/s1;   InChIKey=PAEBIVWUMLRPSK-IDTAVKCVSA-N;   SMILES=C1(=NC(=C2C(=N1)N(C=N2)[C@@H]3O[C@@H]([C@H]([C@H]3O)O)COP(OP(C(P(O)(=O)O)(Cl)Cl)(=O)O)(=O)O)NCCSC)SCCC(F)(F)F
 xref: CAS:163706-06-7 "ChemIDplus";   CAS:163706-06-7 "KEGG DRUG";   Drug_Central:5006 "DrugCentral";   KEGG:D03359
 xref_mesh: MESH:C117446
 xref: PMID:24057605 "Europe PMC";   PMID:24080586 "Europe PMC";   PMID:24192670 "Europe PMC";   PMID:24285121 "Europe PMC";   PMID:24393016 "Europe PMC";   PMID:24479981 "Europe PMC";   PMID:24630878 "Europe PMC";   PMID:24656538 "Europe PMC";   PMID:24762247 "Europe PMC";   PMID:24879371 "Europe PMC";   PMID:25089928 "Europe PMC";   PMID:25123696 "Europe PMC";   PMID:25703887 "Europe PMC";   PMID:25728292 "Europe PMC";   PMID:25728646 "Europe PMC";   PMID:25785060 "Europe PMC";   PMID:26024789 "Europe PMC";   PMID:26201463 "Europe PMC";   PMID:26270719 "Europe PMC";   PMID:26283269 "Europe PMC";   PMID:26381736 "Europe PMC";   PMID:26400827 "Europe PMC";   PMID:26444255 "Europe PMC";   PMID:26680584 "Europe PMC";   Reaxys:8303713 "Reaxys";   Wikipedia:Cangrelor
 cyclic_relationship: is_conjugate_acid_of CHEBI:90843


show annotations for term's descendants       view all columns           Sort by:
 
cangrelor term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:6480464
G Itga2b integrin subunit alpha 2b JBrowse link 10 90,397,960 90,416,550 RGD:6480464
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:6480464
G P2ry12 purinergic receptor P2Y12 JBrowse link 2 149,440,807 149,482,592 RGD:6480464
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      application 19339
        pharmaceutical 19214
          drug 19214
            hematologic agent 4250
              platelet aggregation inhibitor 3332
                cangrelor 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            heteroorganic entity 19067
                              organochalcogen compound 18792
                                organooxygen compound 18704
                                  carbohydrates and carbohydrate derivatives 12099
                                    carbohydrate 12099
                                      carbohydrate derivative 11725
                                        glycosyl compound 10784
                                          N-glycosyl compound 5307
                                            nucleoside 5169
                                              ribonucleoside 688
                                                purine ribonucleoside 584
                                                  adenosines 528
                                                    cangrelor 8
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