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ONTOLOGY REPORT - ANNOTATIONS


Term:cobimetinib
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Accession:CHEBI:90851 term browser browse the term
Definition:A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.
Synonyms:exact_synonym: [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone
 related_synonym: Formula=C21H21F3IN3O2;   GDC-0973;   GDC0973;   InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1;   InChIKey=BSMCAPRUBJMWDF-KRWDZBQOSA-N;   RG 7420;   RG7420;   SMILES=C1=C(C(=C(C(=C1)C(N2CC(C2)(O)[C@H]3NCCCC3)=O)NC4=CC=C(C=C4F)I)F)F;   XL518;   Xl-518
 xref: CAS:934660-93-2 "ChemIDplus";   CAS:934660-93-2 "KEGG DRUG";   DrugBank:DB05239;   Drug_Central:5046 "DrugCentral";   KEGG:D10405
 xref_mesh: MESH:C574276
 xref: PDBeChem:EUI;   PMID:24589925 "Europe PMC";   PMID:25037139 "Europe PMC";   PMID:25142409 "Europe PMC";   PMID:25243894 "Europe PMC";   PMID:25265494 "Europe PMC";   PMID:25444546 "Europe PMC";   PMID:25813936 "Europe PMC";   PMID:26365290 "Europe PMC";   PMID:26384788 "Europe PMC";   PMID:26451002 "Europe PMC";   PMID:26452567 "Europe PMC";   Reaxys:12883594 "Reaxys";   Wikipedia:Cobimetinib
 cyclic_relationship: is_conjugate_base_of CHEBI:90854


show annotations for term's descendants       view all columns           Sort by:
 
cobimetinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      application 19362
        pharmaceutical 19231
          drug 19231
            antineoplastic agent 16895
              cobimetinib 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19646
                    p-block element atom 19646
                      carbon group element atom 19540
                        carbon atom 19529
                          organic molecular entity 19529
                            organic group 18432
                              organic divalent group 18423
                                organodiyl group 18423
                                  carbonyl group 18311
                                    carbonyl compound 18311
                                      carboxylic acid 17978
                                        carboacyl group 17095
                                          univalent carboacyl group 17095
                                            carbamoyl group 16817
                                              carboxamide 16817
                                                N-acylazetidine 10
                                                  cobimetinib 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.