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Accession:CHEBI:90942 term browser browse the term
Definition:A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.
Synonyms:exact_synonym: N-[(1R)-1-borono-3-methylbutyl]-N(2)-(2,5-dichlorobenzoyl)glycinamide
 related_synonym: Formula=C14H19BCl2N2O4;   InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1;   InChIKey=MXAYKZJJDUDWDS-LBPRGKRZSA-N;   MLN 2238;   MLN2238;   SMILES=C(NCC(=O)N[C@@H](CC(C)C)B(O)O)(C1=CC(=CC=C1Cl)Cl)=O
 xref: CAS:1072833-77-2 "ChemIDplus";   CAS:1072833-77-2 "KEGG DRUG";   Drug_Central:5067 "DrugCentral";   KEGG:D10130;   LINCS:LSM-4944
 xref_mesh: MESH:C548400
 xref: PMID:23514361 "Europe PMC";   PMID:24239172 "Europe PMC";   PMID:24292417 "Europe PMC";   PMID:24467634 "Europe PMC";   PMID:24904120 "Europe PMC";   PMID:24920586 "Europe PMC";   PMID:25124778 "Europe PMC";   PMID:25302026 "Europe PMC";   PMID:25325301 "Europe PMC";   PMID:25377318 "Europe PMC";   PMID:25456369 "Europe PMC";   PMID:25777468 "Europe PMC";   PMID:25832873 "Europe PMC";   PMID:25919767 "Europe PMC";   PMID:26141494 "Europe PMC";   PMID:26275080 "Europe PMC";   PMID:26337806 "Europe PMC";   PMID:26588946 "Europe PMC";   PMID:26634271 "Europe PMC";   PMID:26667773 "Europe PMC";   PMID:26709701 "Europe PMC";   Reaxys:18302358 "Reaxys";   Wikipedia:Ixazomib

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ixazomib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lat2 linker for activation of T cells family, member 2 JBrowse link 12 25,114,099 25,128,381 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      biological role 19673
        biochemical role 19178
          apoptosis inducer 10835
            ixazomib 1
              ixazomib citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    p-block element atom 19610
                      carbon group element atom 19501
                        carbon atom 19494
                          organic molecular entity 19494
                            organic group 18413
                              organic divalent group 18404
                                organodiyl group 18404
                                  carbonyl group 18293
                                    carbonyl compound 18293
                                      carboxylic acid 17960
                                        carboacyl group 17072
                                          univalent carboacyl group 17072
                                            carbamoyl group 16801
                                              carboxamide 16801
                                                monocarboxylic acid amide 14163
                                                  arenecarboxamide 6485
                                                    benzamides 6485
                                                      ixazomib 1
                                                        ixazomib citrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.