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Accession:CHEBI:90943 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.
Synonyms:exact_synonym: N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)acrylamide
 related_synonym: AZD-9291;   AZD9291;   Formula=C28H33N7O2;   InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);   InChIKey=DUYJMQONPNNFPI-UHFFFAOYSA-N;   N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide;   SMILES=CN1C=2C(C(C3=NC(NC4=C(OC)C=C(C(=C4)NC(C=C)=O)N(CCN(C)C)C)=NC=C3)=C1)=CC=CC2;   mereletinib;   osimertinibum
 xref: CAS:1421373-65-0 "ChemIDplus";   DrugBank:DB09330;   Drug_Central:5062 "DrugCentral";   LINCS:LSM-6344
 xref_mesh: MESH:C000603933
 xref: PMID:26450446 "Europe PMC";   PMID:26515464 "Europe PMC";   PMID:26620497 "Europe PMC";   PMID:26720284 "Europe PMC";   PMID:26720671 "Europe PMC";   PMID:26729184 "Europe PMC";   PMID:29151359 "Europe PMC";   PMID:29782558 "Europe PMC";   PMID:29852038 "Europe PMC";   PMID:30126856 "Europe PMC";   PMID:30151614 "Europe PMC";   PMID:30153097 "Europe PMC";   PMID:30189719 "Europe PMC";   PMID:30194172 "Europe PMC";   PMID:30224350 "Europe PMC";   Reaxys:23334373 "Reaxys";   Wikipedia:Osimertinib
 cyclic_relationship: is_conjugate_base_of CHEBI:90949

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osimertinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pharmaceutical 19081
          drug 19081
            antineoplastic agent 16550
              osimertinib 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        carboacyl group 16930
                                          univalent carboacyl group 16930
                                            carbamoyl group 16610
                                              carboxamide 16610
                                                alpha,beta-unsaturated carboxylic acid amide 4744
                                                  enamide 4744
                                                    acrylamides 3796
                                                      osimertinib 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.