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ONTOLOGY REPORT - ANNOTATIONS


Term:EC 2.7.11.26 (tau-protein kinase) inhibitor
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Accession:CHEBI:91092 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).
Synonyms:related_synonym: ATP:tau-protein O-phosphotransferase inhibitor;   ATP:tau-protein O-phosphotransferase inhibitors;   CDK5/p23 inhibitor;   CDK5/p23 inhibitors;   EC 2.7.11.26 (tau-protein kinase) inhibitors;   EC 2.7.11.26 inhibitor;   EC 2.7.11.26 inhibitors;   GSK inhibitor;   GSK inhibitors;   GSK-3 inhibitor;   GSK-3 inhibitors;   STK31 inhibitor;   STK31 inhibitors;   TPK I inhibitor;   TPK I inhibitors;   TPK II inhibitor;   TPK II inhibitors;   TPK inhibitor;   TPK inhibitors;   TTK inhibitor;   TTK inhibitors;   brain protein kinase PK40erk inhibitor;   brain protein kinase PK40erk inhibitors;   cdk5/p20 inhibitor;   cdk5/p20 inhibitors;   glycogen synthase kinase-3beta inhibitor;   glycogen synthase kinase-3beta inhibitors;   protein tau kinase inhibitor;   protein tau kinase inhibitors;   tau kinase inhibitor;   tau kinase inhibitors;   tau-protein kinase I inhibitor;   tau-protein kinase I inhibitors;   tau-protein kinase II inhibitor;   tau-protein kinase II inhibitors;   tau-tubulin inhibitor;   tau-tubulin inhibitors
 xref: Wikipedia:GSK-3


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6-bromoindirubin-3'-oxime term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdx1 caudal type homeo box 1 JBrowse link 18 56,337,485 56,355,477 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:6480464
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:6480464
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:6480464
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hoxa1 homeobox A1 JBrowse link 4 82,124,358 82,127,182 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 JBrowse link 7 58,447,097 58,587,787 RGD:6480464
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:6480464
G Pou5f1 POU class 5 homeobox 1 JBrowse link 20 3,747,231 3,751,994 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:6480464
alsterpaullone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
CHIR 99021 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon JBrowse link 11 84,080,273 84,090,259 RGD:6480464
G Esrra estrogen related receptor, alpha JBrowse link 1 222,168,729 222,178,842 RGD:6480464
G Fbxo32 F-box protein 32 JBrowse link 7 98,065,664 98,098,071 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hes5 hes family bHLH transcription factor 5 JBrowse link 5 172,364,421 172,365,188 RGD:6480464
G Lamp1 lysosomal-associated membrane protein 1 JBrowse link 16 81,689,576 81,714,341 RGD:6480464
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 JBrowse link 7 58,447,097 58,587,787 RGD:6480464
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Nes nestin JBrowse link 2 187,343,109 187,352,972 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nrf1 nuclear respiratory factor 1 JBrowse link 4 57,335,732 57,445,317 RGD:6480464
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 JBrowse link 5 173,640,780 173,646,073 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Ppard peroxisome proliferator-activated receptor delta JBrowse link 20 7,818,289 7,883,482 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Rictor RPTOR independent companion of MTOR, complex 2 JBrowse link 2 56,013,898 56,105,818 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tfeb transcription factor EB JBrowse link 9 15,208,141 15,264,101 RGD:6480464
G Tubb3 tubulin, beta 3 class III JBrowse link 19 56,220,759 56,229,813 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:6480464
SB 415286 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Gys1 glycogen synthase 1 JBrowse link 1 101,427,195 101,447,092 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        inhibitor 18169
          enzyme inhibitor 18091
            EC 2.* (transferase) inhibitor 13517
              EC 2.7.* (P-containing group transferase) inhibitor 13181
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8132
                  EC 2.7.11.26 (tau-protein kinase) inhibitor 61
                    1-azakenpaullone 0
                    6-bromoindirubin-3'-oxime 26
                    6-hydroxymanzamine A 0
                    8-hydroxymanzamine A 0
                    CHIR 99021 28
                    GSK3-XIII 0
                    N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                    SB 415286 14
                    alsterpaullone 6
                    manzamine A + 0
                    paullone + 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19711
      biological role 19710
        inhibitor 18169
          enzyme inhibitor 18091
            EC 2.* (transferase) inhibitor 13517
              EC 2.7.* (P-containing group transferase) inhibitor 13181
                protein kinase inhibitor 12661
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8132
                    EC 2.7.11.26 (tau-protein kinase) inhibitor 61
                      1-azakenpaullone 0
                      6-bromoindirubin-3'-oxime 26
                      6-hydroxymanzamine A 0
                      8-hydroxymanzamine A 0
                      CHIR 99021 28
                      GSK3-XIII 0
                      N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                      SB 415286 14
                      alsterpaullone 6
                      manzamine A + 0
                      paullone + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.