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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.26 (tau-protein kinase) inhibitor
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Accession:CHEBI:91092 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).
Synonyms:related_synonym: ATP:tau-protein O-phosphotransferase inhibitor;   ATP:tau-protein O-phosphotransferase inhibitors;   CDK5/p23 inhibitor;   CDK5/p23 inhibitors;   EC 2.7.11.26 (tau-protein kinase) inhibitors;   EC 2.7.11.26 inhibitor;   EC 2.7.11.26 inhibitors;   GSK inhibitor;   GSK inhibitors;   GSK-3 inhibitor;   GSK-3 inhibitors;   STK31 inhibitor;   STK31 inhibitors;   TPK I inhibitor;   TPK I inhibitors;   TPK II inhibitor;   TPK II inhibitors;   TPK inhibitor;   TPK inhibitors;   TTK inhibitor;   TTK inhibitors;   brain protein kinase PK40erk inhibitor;   brain protein kinase PK40erk inhibitors;   cdk5/p20 inhibitor;   cdk5/p20 inhibitors;   glycogen synthase kinase-3beta inhibitor;   glycogen synthase kinase-3beta inhibitors;   protein tau kinase inhibitor;   protein tau kinase inhibitors;   tau kinase inhibitor;   tau kinase inhibitors;   tau-protein kinase I inhibitor;   tau-protein kinase I inhibitors;   tau-protein kinase II inhibitor;   tau-protein kinase II inhibitors;   tau-tubulin inhibitor;   tau-tubulin inhibitors
 xref: Wikipedia:GSK-3


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6-bromoindirubin-3'-oxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression
EXP
ISO
6-bromoindirubin-3'-oxime results in increased expression of and results in increased activity of ABCB1 protein
6-bromoindirubin-3'-oxime results in increased expression of ABCB1 mRNA
6-bromoindirubin-3'-oxime results in increased expression of ABCB1A mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCB1A protein
CTD PMID:18624906 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression EXP 6-bromoindirubin-3'-oxime results in increased expression of ABCC2 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCC2 protein CTD PMID:18624906 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 increases expression EXP 6-bromoindirubin-3'-oxime results in increased expression of ABCC4 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCC4 protein CTD PMID:18624906 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression EXP 6-bromoindirubin-3'-oxime results in increased expression of ABCG2 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCG2 protein CTD PMID:18624906 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP 6-bromoindirubin-3'-oxime binds to and results in increased activity of AHR protein CTD PMID:26259606 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP [sorafenib co-treated with 6-bromoindirubin-3'-oxime] affects the localization of AIFM1 protein CTD PMID:17991738 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G CASP8 caspase 8 multiple interactions EXP 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form] CTD PMID:28414160 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CCND1 cyclin D1 increases expression EXP
ISO
6-bromoindirubin-3'-oxime results in increased expression of CCND1 mRNA CTD PMID:18624906 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDX1 caudal type homeobox 1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in increased expression of CDX1 mRNA CTD PMID:27693483 NCBI chr 5:150,166,778...150,184,558
Ensembl chr 5:150,166,778...150,184,558
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions
increases expression
decreases phosphorylation
EXP [6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein; broussochalcone A inhibits the reaction [6-bromoindirubin-3'-oxime results in increased expression of CTNNB1 protein]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in decreased phosphorylation of CTNNB1 protein] CTD PMID:18624906, PMID:19727391, PMID:26259606, PMID:31163223 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression
multiple interactions
EXP 6-bromoindirubin-3'-oxime results in increased expression of CYP1A2 mRNA
6-bromoindirubin-3'-oxime results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:26259606 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of CYP26A1 mRNA CTD PMID:27693483 NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
JBrowse link
G DDX3X DEAD-box helicase 3 X-linked multiple interactions EXP 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to DDX3X protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of DDX3X protein modified form] CTD PMID:28414160 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472
Ensembl chr  X:41,333,348...41,364,472
JBrowse link
G DHFR dihydrofolate reductase multiple interactions EXP [6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein CTD PMID:19727391 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983
JBrowse link
G DIABLO diablo IAP-binding mitochondrial protein multiple interactions EXP 6-bromoindirubin-3'-oxime promotes the reaction [sorafenib affects the localization of DIABLO protein] CTD PMID:17991738 NCBI chr12:122,207,662...122,227,456
Ensembl chr12:122,207,663...122,227,456
Ensembl chr12:122,207,663...122,227,456
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha multiple interactions EXP 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3A protein modified form] CTD PMID:28414160 NCBI chr19:42,230,186...42,243,330
Ensembl chr19:42,230,190...42,242,625
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases activity
multiple interactions
increases phosphorylation
EXP 6-bromoindirubin-3'-oxime results in decreased activity of GSK3B protein
6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein]
CTD PMID:17991738, PMID:19727391, PMID:28414160 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G HOXA1 homeobox A1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of HOXA1 mRNA CTD PMID:27693483 NCBI chr 7:27,092,993...27,096,000
Ensembl chr 7:27,093,313...27,095,996
Ensembl chr 7:27,093,313...27,095,996
JBrowse link
G IL6 interleukin 6 multiple interactions EXP [6-bromoindirubin-3'-oxime co-treated with Methotrexate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:19727391 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LGR5 leucine rich repeat containing G protein-coupled receptor 5 increases expression EXP 6-bromoindirubin-3'-oxime results in increased expression of LGR5 mRNA CTD PMID:26259606 NCBI chr12:71,439,798...71,586,310
Ensembl chr12:71,439,798...71,586,310
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP 6-bromoindirubin-3'-oxime results in decreased expression of MCL1 protein CTD PMID:17991738 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,574,551...150,579,738
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of PARP1 protein modified form] CTD PMID:28414160 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions EXP 6-bromoindirubin-3'-oxime inhibits the reaction [sorafenib results in decreased expression of PMAIP1 protein] CTD PMID:17991738 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,948...59,904,306
Ensembl chr18:59,899,948...59,904,306
JBrowse link
G POU5F1 POU class 5 homeobox 1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of POU5F1 mRNA CTD PMID:27693483 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [6-bromoindirubin-3'-oxime co-treated with Methotrexate] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:19727391 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions EXP 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to DDX3X protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]] CTD PMID:28414160 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G WNT3 Wnt family member 3 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of WNT3 mRNA CTD PMID:27693483 NCBI chr17:46,762,506...46,818,692
Ensembl chr17:46,762,506...46,833,154
JBrowse link
alsterpaullone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor increases activity EXP alsterpaullone analog results in increased activity of AR protein CTD PMID:21111724 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CASP3 caspase 3 multiple interactions ISO alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein] CTD PMID:20300959 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases activity EXP alsterpaullone results in decreased activity of CDK2 protein CTD PMID:12534346 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases activity EXP alsterpaullone results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G KLK3 kallikrein related peptidase 3 increases expression EXP alsterpaullone results in increased expression of KLK3 mRNA CTD PMID:21111724 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764
JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase decreases activity EXP alsterpaullone results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,239...32,286,165
JBrowse link
G TP53 tumor protein p53 affects localization
multiple interactions
EXP alsterpaullone affects the localization of TP53 protein
alsterpaullone results in decreased degradation of and results in increased expression of TP53 protein
CTD PMID:16055726 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
CHIR 99021 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADVL acyl-CoA dehydrogenase very long chain decreases expression ISO Chir 99021 results in decreased expression of ACADVL mRNA CTD PMID:29883716 NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266
JBrowse link
G ACAN aggrecan decreases expression ISO Chir 99021 results in decreased expression of ACAN mRNA CTD PMID:32220932 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G AFP alpha fetoprotein increases expression EXP Chir 99021 results in increased expression of AFP mRNA CTD PMID:31711903 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP Chir 99021 binds to and results in increased activity of AHR protein; Chir 99021 inhibits the reaction [AHR protein results in decreased expression of VIM protein] CTD PMID:26259606, PMID:27752740 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of ALDH1A2 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866
JBrowse link
G APOA1 apolipoprotein A1 increases expression
multiple interactions
EXP Chir 99021 results in increased expression of APOA1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of APOA1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of APOA1 mRNA]
CTD PMID:31711903 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression ISO Chir 99021 results in increased expression of BGLAP mRNA CTD PMID:32220932 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G CDX1 caudal type homeobox 1 increases expression
multiple interactions
EXP Chir 99021 results in increased expression of CDX1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of CDX1 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of CDX1 mRNA]]
CTD PMID:31711903 NCBI chr 5:150,166,778...150,184,558
Ensembl chr 5:150,166,778...150,184,558
JBrowse link
G CTNNB1 catenin beta 1 increases expression
affects localization
multiple interactions
EXP
ISO
Chir 99021 results in increased expression of CTNNB1 protein
Chir 99021 affects the localization of CTNNB1 protein
Chir 99021 inhibits the reaction [pristimerin results in decreased expression of CTNNB1 protein]
CTD PMID:26259606, PMID:31715269, PMID:32220932 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression EXP Chir 99021 results in increased expression of CYP1A2 mRNA CTD PMID:26259606 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions
increases expression
EXP Chir 99021 results in increased expression of and results in increased activity of CYP2E1 protein
Chir 99021 results in increased expression of CYP2E1 mRNA
CTD PMID:26259606 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP Chir 99021 results in increased expression of CYP3A4 mRNA CTD PMID:26259606 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G EIF2B5 eukaryotic translation initiation factor 2B subunit epsilon multiple interactions ISO Chir 99021 promotes the reaction [GSK3B protein affects the phosphorylation of EIF2B5 protein] CTD PMID:29883716 NCBI chr 3:184,135,023...184,145,311
Ensembl chr 3:184,135,038...184,146,127
JBrowse link
G ESRRA estrogen related receptor alpha increases expression ISO Chir 99021 results in increased expression of ESRRA mRNA CTD PMID:29883716 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743
Ensembl chr11:64,305,497...64,316,743
JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA1 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EYA1 mRNA] CTD PMID:31711903 NCBI chr 8:71,197,433...71,548,104
Ensembl chr 8:71,197,433...71,592,025
JBrowse link
G FBXO32 F-box protein 32 decreases expression
multiple interactions
ISO Chir 99021 results in decreased expression of FBXO32 mRNA
Chir 99021 inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]
CTD PMID:21832246 NCBI chr 8:123,497,889...123,541,206
Ensembl chr 8:123,497,889...123,541,206
JBrowse link
G FGF8 fibroblast growth factor 8 increases expression
multiple interactions
EXP Chir 99021 results in increased expression of FGF8 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of FGF8 mRNA]
CTD PMID:31711903 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,130...101,780,369
JBrowse link
G FOXA1 forkhead box A1 multiple interactions
increases expression
EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of FOXA1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of FOXA1 mRNA] CTD PMID:31711903 NCBI chr14:37,589,552...37,595,249
Ensembl chr14:37,589,552...37,596,059
JBrowse link
G FOXC2 forkhead box C2 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXC2 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXC2 mRNA] CTD PMID:31711903 NCBI chr16:86,566,829...86,569,728
Ensembl chr16:86,566,829...86,569,728
JBrowse link
G GATA6 GATA binding protein 6 increases expression
multiple interactions
EXP Chir 99021 results in increased expression of GATA6 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of GATA6 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of GATA6 mRNA]
CTD PMID:31711903 NCBI chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
Ensembl chr18:22,169,589...22,202,528
JBrowse link
G GSK3B glycogen synthase kinase 3 beta affects phosphorylation
decreases activity
multiple interactions
EXP
ISO
Chir 99021 affects the phosphorylation of GSK3B protein
Chir 99021 results in decreased activity of GSK3B protein
Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]; Chir 99021 promotes the reaction [GSK3B protein affects the expression of PPARGC1A protein]; Chir 99021 promotes the reaction [GSK3B protein affects the phosphorylation of EIF2B5 protein]
CTD PMID:27752740, PMID:29883716, PMID:30165626 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G H19 H19 imprinted maternally expressed transcript increases expression EXP Chir 99021 results in increased expression of H19 mRNA CTD PMID:31711903 NCBI chr11:1,995,176...2,001,466
Ensembl chr11:1,995,176...2,001,470
JBrowse link
G HES5 hes family bHLH transcription factor 5 multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of HES5 mRNA CTD PMID:20865013 NCBI chr 1:2,528,745...2,530,554
Ensembl chr 1:2,528,745...2,530,263
JBrowse link
G HES7 hes family bHLH transcription factor 7 multiple interactions
increases expression
EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HES7 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HES7 mRNA]] CTD PMID:31711903 NCBI chr17:8,120,590...8,126,032
Ensembl chr17:8,120,592...8,124,106
JBrowse link
G HOXB1 homeobox B1 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB1 mRNA CTD PMID:31711903 NCBI chr17:48,528,526...48,531,011
Ensembl chr17:48,528,526...48,531,011
JBrowse link
G HOXB3 homeobox B3 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB3 mRNA CTD PMID:31711903 NCBI chr17:48,548,870...48,590,241
Ensembl chr17:48,548,870...48,604,912
JBrowse link
G HOXB5 homeobox B5 multiple interactions EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the reaction [Chir 99021 results in increased expression of HOXB5 mRNA]; Tretinoin affects the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the reaction [Chir 99021 results in increased expression of HOXB5 mRNA]] CTD PMID:31711903 NCBI chr17:48,591,257...48,593,779
Ensembl chr17:48,591,257...48,593,961
JBrowse link
G HOXB7 homeobox B7 multiple interactions
increases expression
EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of HOXB7 mRNA] CTD PMID:31711903 NCBI chr17:48,607,232...48,611,017
Ensembl chr17:48,607,232...48,633,572
JBrowse link
G HOXB9 homeobox B9 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr17:48,621,156...48,626,358
Ensembl chr17:48,621,156...48,626,358
JBrowse link
G IHH Indian hedgehog signaling molecule increases expression
multiple interactions
EXP Chir 99021 results in increased expression of IHH mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of IHH mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of IHH mRNA]
CTD PMID:31711903 NCBI chr 2:219,054,424...219,060,921
Ensembl chr 2:219,054,424...219,060,921
JBrowse link
G LAMP1 lysosomal associated membrane protein 1 multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of LAMP1 protein] CTD PMID:30165626 NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672
JBrowse link
G LGR5 leucine rich repeat containing G protein-coupled receptor 5 increases expression EXP Chir 99021 results in increased expression of LGR5 mRNA CTD PMID:26259606 NCBI chr12:71,439,798...71,586,310
Ensembl chr12:71,439,798...71,586,310
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MAP1LC3A protein] CTD PMID:30165626 NCBI chr20:34,546,823...34,560,345
Ensembl chr20:34,546,854...34,560,345
JBrowse link
G MEOX1 mesenchyme homeobox 1 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEOX1 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MEOX1 mRNA] CTD PMID:31711903 NCBI chr17:43,640,389...43,661,977
Ensembl chr17:43,640,389...43,661,922
JBrowse link
G MESP2 mesoderm posterior bHLH transcription factor 2 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MESP2 mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MESP2 mRNA] CTD PMID:31711903 NCBI chr15:89,776,332...89,778,754
Ensembl chr15:89,760,591...89,778,754
JBrowse link
G MPP1 membrane palmitoylated protein 1 increases expression
multiple interactions
EXP Chir 99021 results in increased expression of MPP1 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of MPP1 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of MPP1 mRNA]
CTD PMID:31711903 NCBI chr  X:154,778,684...154,805,485
Ensembl chr  X:154,778,684...154,821,007
JBrowse link
G MSGN1 mesogenin 1 multiple interactions
increases expression
EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of MSGN1 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of MSGN1 mRNA]] CTD PMID:31711903 NCBI chr 2:17,816,460...17,817,798
Ensembl chr 2:17,816,460...17,817,798
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Chir 99021 results in increased expression of MYC protein CTD PMID:25897075 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NANOG Nanog homeobox decreases expression EXP Chir 99021 results in decreased expression of NANOG mRNA CTD PMID:31711903 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146
JBrowse link
G NES nestin multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of NES mRNA CTD PMID:20865013 NCBI chr 1:156,668,763...156,677,407
Ensembl chr 1:156,668,763...156,677,407
JBrowse link
G NEUROG2 neurogenin 2 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 4:112,513,516...112,516,180
Ensembl chr 4:112,513,516...112,516,180
JBrowse link
G NODAL nodal growth differentiation factor increases expression
multiple interactions
EXP Chir 99021 results in increased expression of NODAL mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of NODAL mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of NODAL mRNA]
CTD PMID:31711903 NCBI chr10:70,431,936...70,447,951
Ensembl chr10:70,431,936...70,447,951
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP Chir 99021 binds to and results in increased activity of NR1I2 protein CTD PMID:26259606 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NRF1 nuclear respiratory factor 1 decreases expression ISO Chir 99021 results in decreased expression of NRF1 mRNA CTD PMID:29883716 NCBI chr 7:129,611,720...129,757,076
Ensembl chr 7:129,611,720...129,757,082
JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394
JBrowse link
G PAX3 paired box 3 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of PAX3 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 2:222,199,887...222,298,998
Ensembl chr 2:222,199,888...222,298,996
Ensembl chr 2:222,199,888...222,298,996
JBrowse link
G PAX6 paired box 6 multiple interactions
increases expression
EXP [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] promotes the reaction [Chir 99021 results in increased expression of PAX6 mRNA] CTD PMID:31711903 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
G PERM1 PPARGC1 and ESRR induced regulator, muscle 1 increases expression ISO Chir 99021 results in increased expression of PERM1 mRNA CTD PMID:29883716 NCBI chr 1:975,198...982,093
Ensembl chr 1:975,204...982,093
JBrowse link
G POU5F1 POU class 5 homeobox 1 decreases expression EXP Chir 99021 results in decreased expression of POU5F1 mRNA CTD PMID:31711903 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression ISO Chir 99021 results in decreased expression of PPARA mRNA CTD PMID:29883716 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARD peroxisome proliferator activated receptor delta decreases expression ISO Chir 99021 results in decreased expression of PPARD mRNA CTD PMID:29883716 NCBI chr 6:35,342,558...35,428,180
Ensembl chr 6:35,342,558...35,428,191
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions
increases expression
ISO Chir 99021 promotes the reaction [GSK3B protein affects the expression of PPARGC1A protein]
Chir 99021 results in increased expression of PPARGC1A mRNA; Chir 99021 results in increased expression of PPARGC1A protein
CTD PMID:29883716 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G RICTOR RPTOR independent companion of MTOR complex 2 increases expression EXP Chir 99021 results in increased expression of RICTOR protein CTD PMID:25897075 NCBI chr 5:38,937,920...39,074,421
Ensembl chr 5:38,937,920...39,074,399
JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO Chir 99021 results in increased expression of RUNX2 mRNA CTD PMID:32220932 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SOX17 SRY-box transcription factor 17 increases expression
multiple interactions
EXP Chir 99021 results in increased expression of SOX17 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Chir 99021 results in increased expression of SOX17 mRNA]; [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in increased expression of SOX17 mRNA]
CTD PMID:31711903 NCBI chr 8:54,457,935...54,460,892
Ensembl chr 8:54,457,935...54,460,892
JBrowse link
G SOX2 SRY-box transcription factor 2 decreases expression
multiple interactions
EXP Chir 99021 results in decreased expression of SOX2 mRNA
[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] inhibits the reaction [Chir 99021 results in decreased expression of SOX2 mRNA]
CTD PMID:31711903 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G SOX9 SRY-box transcription factor 9 decreases expression ISO Chir 99021 results in decreased expression of SOX9 mRNA CTD PMID:32220932 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SP7 Sp7 transcription factor increases expression
affects localization
ISO Chir 99021 results in increased expression of SP7 mRNA
Chir 99021 affects the localization of SP7 protein
CTD PMID:32220932 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein] CTD PMID:30165626 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SYP synaptophysin multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of SYP mRNA CTD PMID:20865013 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,815...49,200,199
Ensembl chr  X:49,187,815...49,200,199
JBrowse link
G TBX1 T-box transcription factor 1 multiple interactions
increases expression
EXP 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of BRACHYURY mRNA]; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of BRACHYURY mRNA CTD PMID:31711903 NCBI chr22:19,756,703...19,783,593
Ensembl chr22:19,756,703...19,783,593
JBrowse link
G TBX6 T-box transcription factor 6 increases expression
multiple interactions
EXP Chir 99021 results in increased expression of TBX6 mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of TBX6 mRNA]; Tretinoin inhibits the reaction [4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of TBX6 mRNA]]
CTD PMID:31711903 NCBI chr16:30,085,793...30,091,927
Ensembl chr16:30,085,793...30,091,924
Ensembl chr16:30,085,793...30,091,924
JBrowse link
G TCF15 transcription factor 15 multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of TCF15 mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr20:604,257...610,309
Ensembl chr20:603,797...610,398
JBrowse link
G TFEB transcription factor EB multiple interactions ISO Chir 99021 affects the reaction [1-Methyl-4-phenylpyridinium affects the localization of TFEB protein]; Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [GSK3B protein binds to TFEB protein]]; Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [YWHAQ protein binds to TFEB protein]] CTD PMID:30165626 NCBI chr 6:41,683,978...41,736,223
Ensembl chr 6:41,683,978...41,736,259
JBrowse link
G TUBB3 tubulin beta 3 class III multiple interactions ISO [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide co-treated with SU 5402 co-treated with Chir 99021] results in decreased expression of TUBB3 mRNA CTD PMID:20865013 NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761
JBrowse link
G UNCX UNC homeobox multiple interactions EXP [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNCX mRNA; Tretinoin inhibits the reaction [[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNCX mRNA] CTD PMID:31711903 NCBI chr 7:1,232,872...1,237,326
Ensembl chr 7:1,232,872...1,237,326
JBrowse link
G VIM vimentin multiple interactions EXP Chir 99021 inhibits the reaction [AHR protein results in decreased expression of VIM protein] CTD PMID:27752740 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593
JBrowse link
G WNT3A Wnt family member 3A increases expression
multiple interactions
EXP Chir 99021 results in increased expression of WNT3A mRNA
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide promotes the reaction [Chir 99021 results in increased expression of WNT3A mRNA]; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of WNT3A mRNA
CTD PMID:31711903 NCBI chr 1:228,006,998...228,067,113
Ensembl chr 1:228,006,998...228,061,271
JBrowse link
G WNT5A Wnt family member 5A increases expression
multiple interactions
EXP Chir 99021 results in increased expression of WNT5A mRNA
[Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with Tretinoin] results in increased expression of WNT5A mRNA; [Chir 99021 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT5A mRNA
CTD PMID:31711903 NCBI chr 3:55,465,715...55,505,261
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
G YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta multiple interactions ISO Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium promotes the reaction [YWHAQ protein binds to TFEB protein]] CTD PMID:30165626 NCBI chr 2:9,583,967...9,630,997
Ensembl chr 2:9,583,967...9,630,997
JBrowse link
SB 415286 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G CASP8 caspase 8 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein] CTD PMID:15475000, PMID:15942663 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CCND1 cyclin D1 increases expression
multiple interactions
ISO
EXP
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
CTD PMID:15753396, PMID:25381574 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
EXP
ISO
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased phosphorylation of CREB1 protein
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [sodium arsenite results in decreased phosphorylation of CREB1 protein]
CTD PMID:23292070, PMID:29723552 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions ISO [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein CTD PMID:19159680 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased expression of and affects the localization of FAS protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein] CTD PMID:15475000 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
decreases activity
EXP
ISO
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]
[3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein
CTD PMID:15753396, PMID:19159680, PMID:31563592 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein] CTD PMID:23292070 NCBI chr19:48,968,130...48,993,309
Ensembl chr19:48,968,130...48,993,310
JBrowse link
G IL6 interleukin 6 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA] CTD PMID:24560772 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 increases expression
multiple interactions
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA
bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA]
CTD PMID:25381574 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein] CTD PMID:22155090 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:23292070 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Cisplatin results in increased expression of TNF mRNA] CTD PMID:24560772 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G WNT3A Wnt family member 3A multiple interactions ISO [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione co-treated with WNT3A protein] results in increased expression of CCND1 mRNA; WNT3A protein promotes the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of LEF1 mRNA] CTD PMID:25381574 NCBI chr 1:228,006,998...228,067,113
Ensembl chr 1:228,006,998...228,061,271
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24370
    role 24278
      biological role 24245
        inhibitor 21467
          enzyme inhibitor 21388
            EC 2.* (transferase) inhibitor 14973
              EC 2.7.* (P-containing group transferase) inhibitor 14664
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8671
                  EC 2.7.11.26 (tau-protein kinase) inhibitor 102
                    1-azakenpaullone 0
                    6-bromoindirubin-3'-oxime 27
                    6-hydroxymanzamine A 0
                    8-hydroxymanzamine A 0
                    CHIR 99021 70
                    GSK3-XIII 0
                    N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                    SB 415286 14
                    SGC-CLK-1 0
                    TDZD-8 0
                    alsterpaullone 7
                    manzamine A + 0
                    paullone + 7
                    tideglusib 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 24370
    role 24278
      biological role 24245
        inhibitor 21467
          enzyme inhibitor 21388
            EC 2.* (transferase) inhibitor 14973
              EC 2.7.* (P-containing group transferase) inhibitor 14664
                protein kinase inhibitor 14050
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8671
                    EC 2.7.11.26 (tau-protein kinase) inhibitor 102
                      1-azakenpaullone 0
                      6-bromoindirubin-3'-oxime 27
                      6-hydroxymanzamine A 0
                      8-hydroxymanzamine A 0
                      CHIR 99021 70
                      GSK3-XIII 0
                      N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                      SB 415286 14
                      SGC-CLK-1 0
                      TDZD-8 0
                      alsterpaullone 7
                      manzamine A + 0
                      paullone + 7
                      tideglusib 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.