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Accession:CHEBI:9150 term browser browse the term
Definition:A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Synonyms:exact_synonym: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
 related_synonym: 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one;   Formula=C25H38O5;   InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1;   InChIKey=RYMZZMVNJRMUDD-HGQWONQESA-N;   MK-733;   SMILES=CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12;   Simvastatina;   Simvastatine;   Simvastatinum;   Zocor
 alt_id: CHEBI:45577
 xref: Beilstein:4768037;   CAS:79902-63-9;   DrugBank:DB00641;   Drug_Central:2445;   KEGG:D00434;   LINCS:LSM-2492
 xref_mesh: MESH:D019821
 xref: PMID:11336576;   PMID:12827636;   PMID:14561068;   PMID:14973129;   PMID:18199328;   PMID:18688862;   PMID:18936176;   Patent:EP33538;   Patent:US4444784;   Wikipedia:Simvastatin

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simvastatin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 84,380,245 84,401,117 RGD:6480464
G LDLR low density lipoprotein receptor JBrowse link 2 69,828,348 69,864,823 RGD:6480464
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 18 50,726,854 50,757,676 RGD:6480464
G NR4A3 nuclear receptor subfamily 4 group A member 3 JBrowse link 1 241,569,867 241,611,735 RGD:6480464
G SREBF1 sterol regulatory element binding transcription factor 1 JBrowse link 12 60,733,967 60,750,951 RGD:6480464
G SREBF2 sterol regulatory element binding transcription factor 2 JBrowse link 5 6,719,484 6,784,724 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 847
    role 824
      application 462
        pro-agent 14
          prodrug 12
            simvastatin 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 847
    subatomic particle 831
      composite particle 831
        hadron 831
          baryon 831
            nucleon 831
              atomic nucleus 831
                atom 831
                  main group element atom 819
                    p-block element atom 816
                      carbon group element atom 787
                        carbon atom 783
                          organic molecular entity 783
                            organic group 361
                              organic divalent group 359
                                organodiyl group 359
                                  carbonyl group 358
                                    carbonyl compound 358
                                      carboxylic acid 242
                                        monocarboxylic acid 131
                                          fatty acid 77
                                            short-chain fatty acid 44
                                              fatty acid 4:0 38
                                                butyric acid 10
                                                  methylbutyric acid 6
                                                    2-methylbutyric acid 6
                                                      (S)-2-methylbutyric acid 6
                                                        lovastatin 6
                                                          simvastatin 6
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