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ONTOLOGY REPORT - ANNOTATIONS


Term:streptonigrin
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Accession:CHEBI:9287 term browser browse the term
Definition:Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
Synonyms:exact_synonym: 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylic acid
 related_synonym: 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;   Formula=C25H22N4O8;   InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34);   InChIKey=PVYJZLYGTZKPJE-UHFFFAOYSA-N;   SMILES=COc1ccc(c(O)c1OC)-c1c(C)c(nc(c1N)-c1ccc2C(=O)C(OC)=C(N)C(=O)c2n1)C(O)=O;   Streptonigran;   rufocromomicina;   rufocromomycin;   rufocromomycine;   rufocromomycinum
 alt_id: CHEBI:108632
 xref: Beilstein:599390 "Beilstein";   CAS:3930-19-6 "ChemIDplus";   CAS:3930-19-6 "KEGG COMPOUND";   Gmelin:1240693 "Gmelin";   KEGG:C02081;   KEGG:D05931;   KNApSAcK:C00026485
 xref_mesh: MESH:D013308
 xref: PMID:10328288 "ChEMBL";   PMID:10465544 "ChEMBL";   PMID:1905760 "ChEMBL";   PMID:2738877 "ChEMBL"


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streptonigrin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        antimicrobial agent 17215
          streptonigrin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      carbon group element atom 19515
                        carbon atom 19508
                          organic molecular entity 19508
                            organic molecule 19431
                              organic cyclic compound 19197
                                organic heterocyclic compound 18267
                                  organonitrogen heterocyclic compound 17179
                                    quinolines 2471
                                      quinolone 298
                                        streptonigrin 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.