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ONTOLOGY REPORT - ANNOTATIONS


Term:terbinafine
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Accession:CHEBI:9448 term browser browse the term
Definition:A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.
Synonyms:exact_synonym: (2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine
 related_synonym: (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine;   (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine;   Formula=C21H25N;   InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+;   InChIKey=DOMXUEMWDBAQBQ-WEVVVXLNSA-N;   SMILES=CN(C\\C=C\\C#CC(C)(C)C)Cc1cccc2ccccc12;   terbinafina;   terbinafinum
 xref: CAS:91161-71-6 "ChemIDplus";   CAS:91161-71-6 "KEGG COMPOUND";   DrugBank:DB00857;   Drug_Central:2597 "DrugCentral";   HMDB:HMDB0014995;   KEGG:C08079;   KEGG:D02375
 xref_mesh: MESH:C041359
 xref: MetaCyc:CPD-10571;   PMID:23750489 "Europe PMC";   PMID:23802806 "Europe PMC";   PMID:23841559 "Europe PMC";   PMID:23895037 "Europe PMC";   PMID:24126579 "Europe PMC";   PMID:24352873 "Europe PMC";   PMID:24389279 "Europe PMC";   PMID:24410098 "Europe PMC";   PMID:24447130 "Europe PMC";   PMID:24452843 "Europe PMC";   PMID:24477462 "Europe PMC";   PMID:24490976 "Europe PMC";   PMID:24497012 "Europe PMC";   PMID:24533442 "Europe PMC";   PMID:24563892 "Europe PMC";   PMID:24576265 "Europe PMC";   PMID:24581620 "Europe PMC";   PMID:24588014 "Europe PMC";   Reaxys:4256376 "Reaxys";   Wikipedia:Terbinafine
 cyclic_relationship: is_conjugate_base_of CHEBI:77615


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terbinafine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl27 C-C motif chemokine ligand 27 JBrowse link 5 58,159,066 58,166,182 RGD:6480464
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6480464
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Ptger2 prostaglandin E receptor 2 JBrowse link 15 19,336,029 19,349,759 RGD:6480464
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:6480464
G Ptk2 protein tyrosine kinase 2 JBrowse link 7 114,436,419 114,611,317 RGD:6480464
G Pxn paxillin JBrowse link 12 46,797,953 46,845,107 RGD:6480464
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:6480464
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:6480464
G Rhoc ras homolog family member C JBrowse link 2 207,271,692 207,278,010 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tslp thymic stromal lymphopoietin JBrowse link 18 25,613,601 25,618,066 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19748
    role 19695
      biological role 19693
        inhibitor 18167
          sterol biosynthesis inhibitor 2894
            terbinafine 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19748
    subatomic particle 19744
      composite particle 19744
        hadron 19744
          baryon 19744
            nucleon 19744
              atomic nucleus 19744
                atom 19744
                  main group element atom 19628
                    main group molecular entity 19628
                      s-block molecular entity 19393
                        hydrogen molecular entity 19382
                          hydrides 18296
                            inorganic hydride 17211
                              pnictogen hydride 17174
                                nitrogen hydride 17010
                                  azane 16703
                                    ammonia 16700
                                      organic amino compound 16699
                                        tertiary amino compound 8576
                                          tertiary amine 603
                                            terbinafine 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.