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ONTOLOGY REPORT - ANNOTATIONS


Term:tetrabenazine
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Accession:CHEBI:9467 term browser browse the term
Definition:A racemate consisting of equal amounts of (3R,11bR)- and (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one. An adrenergic uptake inhibitor, it was formerly used as an antipsychotic, but it is now used mainly for the treatment of various movement disorders including chorea, ballism, dystonias, and tardive dyskinesia.
Synonyms:exact_synonym: rac-(3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
 related_synonym: 1,2,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one;   1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo(a)quinolizin-2-one;   2-oxo-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzoquinolizine;   Nitoman;   Ro 1-9569;   TBZ;   Xenazine;   tetrabenazina;   tetrabenazinum
 xref: CAS:58-46-8;   DrugBank:DB04844;   KEGG:C11168;   KEGG:D08575
 xref_mesh: MESH:D013747
 xref: PMID:10686169;   PMID:19929707;   PMID:20442355;   PMID:20869622;   PMID:21487088;   PMID:9040721;   Patent:US2830993;   Reaxys:9356999;   Wikipedia:Tetrabenazine


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tetrabenazine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc18a1 solute carrier family 18 member A1 JBrowse link 16 22,358,646 22,395,183 RGD:6480464
G Slc18a2 solute carrier family 18 member A2 JBrowse link 1 280,397,831 280,457,968 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      chemical substance 11517
        mixture 10838
          racemate 9724
            tetrabenazine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18465
                              organic divalent group 18458
                                organodiyl group 18458
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      ketone 15949
                                        cyclic ketone 13449
                                          9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one 2
                                            (3R,11bR)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one 2
                                              tetrabenazine 2
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