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ONTOLOGY REPORT - ANNOTATIONS


Term:tioguanine
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Accession:CHEBI:9555 term browser browse the term
Definition:A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.
Synonyms:exact_synonym: 2-amino-1,9-dihydro-6H-purine-6-thione
 related_synonym: 2-Amino 6MP;   2-Amino-1,7-dihydro-6H-purine-6-thione;   2-Amino-6-mercaptopurine;   2-Amino-6-merkaptopurin;   2-Amino-6-purinethiol;   2-Aminopurin-6-thiol;   2-Aminopurine-6(1H)-thione;   2-Aminopurine-6-thiol;   2-amino-1,9-dihydropurine-6-thione;   6-Mercapto-2-aminopurine;   6-Mercaptoguanine;   6-TG;   6-Thioguanine;   Formula=C5H5N5S;   InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11);   InChIKey=WYWHKKSPHMUBEB-UHFFFAOYSA-N;   SMILES=Nc1nc2[nH]cnc2c(=S)[nH]1;   TG;   ThG;   Thioguanine;   Tioguanin;   tioguanina;   tioguaninum
 xref: CAS:154-42-7 "ChemIDplus";   CAS:154-42-7 "KEGG COMPOUND";   DrugBank:DB00352;   Drug_Central:2632 "DrugCentral";   KEGG:C07648;   KEGG:D08603;   KNApSAcK:C00018807;   LINCS:LSM-6723
 xref_mesh: MESH:D013866
 xref: MetaCyc:CPD-5721;   PDBeChem:DX4;   PMID:21803983 "Europe PMC";   PMID:22178190 "Europe PMC";   PMID:22245861 "Europe PMC";   PMID:22261533 "Europe PMC";   PMID:22280519 "Europe PMC";   PMID:22563779 "Europe PMC";   PMID:22646133 "Europe PMC";   PMID:22822082 "Europe PMC";   PMID:22983983 "Europe PMC";   PMID:23259153 "Europe PMC";   PMID:23261807 "Europe PMC";   PMID:23377192 "Europe PMC";   PMID:23377281 "Europe PMC";   PMID:23393198 "Europe PMC";   PMID:28166217 "Europe PMC";   Reaxys:1074099 "Reaxys";   Wikipedia:Thioguanine


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tioguanine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Abcc5 ATP binding cassette subfamily C member 5 JBrowse link 11 84,395,982 84,490,215 RGD:6480464
G Acer2 alkaline ceramidase 2 JBrowse link 5 105,230,540 105,279,732 RGD:6480464
G Acp3 acid phosphatase 3 JBrowse link 8 112,838,574 112,884,062 RGD:6480464
G Alas2 5'-aminolevulinate synthase 2 JBrowse link X 23,167,576 23,187,356 RGD:6480464
G Alox12 arachidonate 12-lipoxygenase, 12S type JBrowse link 10 56,851,734 56,864,049 RGD:6480464
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:6480464
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6480464
G Cdc25b cell division cycle 25B JBrowse link 3 123,731,539 123,741,696 RGD:6480464
G Cdkn3 cyclin-dependent kinase inhibitor 3 JBrowse link 15 23,553,171 23,564,538 RGD:6480464
G Cgref1 cell growth regulator with EF hand domain 1 JBrowse link 6 26,797,126 26,809,132 RGD:6480464
G Col5a3 collagen type V alpha 3 chain JBrowse link 8 21,786,324 21,831,751 RGD:6480464
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:6480464
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:6480464
G Enc1 ectodermal-neural cortex 1 JBrowse link 2 28,049,217 28,061,023 RGD:6480464
G Espn espin JBrowse link 5 169,293,356 169,331,338 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fbln5 fibulin 5 JBrowse link 6 125,644,797 125,723,957 RGD:6480464
G Fkbp5 FKBP prolyl isomerase 5 JBrowse link 20 7,976,704 8,097,290 RGD:6480464
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 JBrowse link 15 45,479,662 45,550,285 RGD:6480464
G Hacl1 2-hydroxyacyl-CoA lyase 1 JBrowse link 16 7,720,047 7,758,119 RGD:6480464
G Hprt1 hypoxanthine phosphoribosyltransferase 1 JBrowse link X 158,196,640 158,228,815 RGD:6480464
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:6480464
G Impdh2 inosine monophosphate dehydrogenase 2 JBrowse link 8 117,346,983 117,351,619 RGD:6480464
G Islr immunoglobulin superfamily containing leucine-rich repeat JBrowse link 8 62,946,732 62,949,675 RGD:6480464
G Kif2c kinesin family member 2C JBrowse link 5 136,027,923 136,053,268 RGD:6480464
G Lig1 DNA ligase 1 JBrowse link 1 75,356,212 75,394,757 RGD:6480464
G Lsp1 lymphocyte-specific protein 1 JBrowse link 1 215,628,750 215,662,505 RGD:6480464
G Mocos molybdenum cofactor sulfurase JBrowse link 18 16,590,086 16,636,312 RGD:6480464
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:6480464
G Mybl2 MYB proto-oncogene like 2 JBrowse link 3 159,421,638 159,450,087 RGD:6480464
G Nek6 NIMA-related kinase 6 JBrowse link 3 22,811,927 22,888,598 RGD:6480464
G Ngef neuronal guanine nucleotide exchange factor JBrowse link 9 94,569,286 94,601,852 RGD:6480464
G Nid2 nidogen 2 JBrowse link 15 4,893,999 4,951,893 RGD:6480464
G Npr1 natriuretic peptide receptor 1 JBrowse link 2 189,840,403 189,857,032 RGD:6480464
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6480464
G Orm1 orosomucoid 1 JBrowse link 5 79,179,668 79,182,820 RGD:6480464
G Pknox2 PBX/knotted 1 homeobox 2 JBrowse link 8 39,361,698 39,551,700 RGD:6480464
G Pkp2 plakophilin 2 JBrowse link 11 88,912,163 88,972,213 RGD:6480464
G Pnpla2 patatin-like phospholipase domain containing 2 JBrowse link 1 214,434,638 214,439,720 RGD:6480464
G Prph peripherin JBrowse link 7 140,742,406 140,746,197 RGD:6480464
G Pth2r parathyroid hormone 2 receptor JBrowse link 9 72,052,966 72,158,343 RGD:6480464
G Rfc3 replication factor C subunit 3 JBrowse link 12 1,460,581 1,471,344 RGD:6480464
G Scn1b sodium voltage-gated channel beta subunit 1 JBrowse link 1 89,550,738 89,560,469 RGD:6480464
G Septin4 septin 4 JBrowse link 10 74,860,068 74,884,196 RGD:6480464
G Slc19a2 solute carrier family 19 member 2 JBrowse link 13 82,552,586 82,566,586 RGD:6480464
G Slc3a2 solute carrier family 3 member 2 JBrowse link 1 224,906,566 224,921,029 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Zfp189 zinc finger protein 189 JBrowse link 5 64,789,432 64,801,079 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      biological role 19596
        biochemical role 19125
          antimetabolite 8457
            tioguanine 51
              6-methylthioguanine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic molecule 19327
                              organic cyclic compound 19076
                                organic heterocyclic compound 18151
                                  organic heteropolycyclic compound 17415
                                    organic heterobicyclic compound 15891
                                      imidazopyrimidine 5406
                                        purines 5404
                                          aminopurine 4368
                                            2-aminopurines 3994
                                              tioguanine 51
                                                6-methylthioguanine 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.