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ONTOLOGY REPORT - ANNOTATIONS


Term:tienilic acid
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Accession:CHEBI:9590 term browser browse the term
Definition:An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links with hepatitis.
Synonyms:exact_synonym: [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid
 related_synonym: (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid;   (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid;   4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure;   4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid;   Formula=C13H8Cl2O4S;   InChI=1S/C13H8Cl2O4S/c14-11-7(13(18)9-2-1-5-20-9)3-4-8(12(11)15)19-6-10(16)17/h1-5H,6H2,(H,16,17);   InChIKey=AGHANLSBXUWXTB-UHFFFAOYSA-N;   SMILES=OC(=O)COc1ccc(C(=O)c2cccs2)c(Cl)c1Cl;   Thienylic acid;   Ticrynafen;   acide tienilique;   acido tienilico;   acidum tienilicum
 xref: CAS:40180-04-9 "ChemIDplus";   CAS:40180-04-9 "KEGG COMPOUND";   DrugBank:DB04831;   Drug_Central:2658 "DrugCentral";   KEGG:C11702;   KEGG:D02386;   LINCS:LSM-5478
 xref_mesh: MESH:D013989
 xref: PMID:22462724 "Europe PMC";   PMID:23013248 "Europe PMC";   PMID:24575896 "Europe PMC";   PMID:2714684 "Europe PMC";   PMID:41229 "Europe PMC";   PMID:471149 "Europe PMC";   PMID:471154 "Europe PMC";   PMID:504040 "Europe PMC";   PMID:6996137 "Europe PMC";   PMID:7004678 "Europe PMC";   PMID:7074982 "Europe PMC";   PMID:7128663 "Europe PMC";   PMID:7398677 "Europe PMC";   PMID:8823314 "Europe PMC";   PMID:913063 "Europe PMC";   Reaxys:1260086 "Reaxys";   Wikipedia:Tienilic_acid


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tienilic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Slc12a2 solute carrier family 12 member 2 JBrowse link 18 52,917,124 52,985,281 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19716
    role 19663
      biological role 19661
        aetiopathogenetic role 18783
          hepatotoxic agent 14291
            tienilic acid 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19716
    subatomic particle 19712
      composite particle 19712
        hadron 19712
          baryon 19712
            nucleon 19712
              atomic nucleus 19712
                atom 19712
                  main group element atom 19598
                    p-block element atom 19598
                      carbon group element atom 19486
                        carbon atom 19480
                          organic molecular entity 19480
                            organic molecule 19402
                              organic cyclic compound 19158
                                carbocyclic compound 17533
                                  benzenoid aromatic compound 17061
                                    benzenes 16782
                                      chlorobenzenes 12678
                                        dichlorobenzene 9743
                                          tienilic acid 5
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