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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolnaftate
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Accession:CHEBI:9620 term browser browse the term
Definition:A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.
Synonyms:exact_synonym: O-2-naphthyl methyl(3-methylphenyl)carbamothioate
 related_synonym: 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate;   Formula=C19H17NOS;   InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3;   InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N;   Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester;   N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide;   O-2-Naphthyl m,N-dimethylthiocarbanilate;   SMILES=CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1;   Separin;   Tinactin;   Tolnaphthate;   m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester;   tolnaftato;   tolnaftatum
 xref: CAS:2398-96-1;   DrugBank:DB00525;   Drug_Central:3617;   HMDB:HMDB0005005;   KEGG:D00381;   LINCS:LSM-5554
 xref_mesh: MESH:D014047
 xref: PMID:20347664;   PMID:2061794;   PMID:20635527;   PMID:21565546;   PMID:22125963;   PMID:24706116;   PMID:3509341;   PMID:4568708;   PMID:5319027;   PMID:5705341;   PMID:5745067;   PMID:5847820;   PMID:5856396;   PMID:5952516;   PMID:697362;   Patent:US2010035939;   Patent:WO2010037089;   Reaxys:2752620;   Wikipedia:Tolnaftate


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tolnaftate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI1 GLI family zinc finger 1 multiple interactions EXP
ISO
Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr12:57,459,785...57,472,451
Ensembl chr12:57,459,785...57,472,268
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Tolnaftate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G IL4 interleukin 4 multiple interactions
decreases expression
decreases secretion
EXP 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533, PMID:15284827 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL5 interleukin 5 multiple interactions
decreases secretion
decreases expression
EXP 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533, PMID:15284827 NCBI chr 5:132,539,194...132,556,864
Ensembl chr 5:132,541,445...132,556,838
JBrowse link
G SHH sonic hedgehog signaling molecule multiple interactions EXP
ISO
Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 24374
    role 24282
      biological role 24249
        aetiopathogenetic role 23036
          genotoxin 18344
            2-naphthol 33
              tolnaftate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 24374
    subatomic particle 24331
      composite particle 24331
        hadron 24331
          baryon 24331
            nucleon 24331
              atomic nucleus 24331
                atom 24331
                  main group element atom 24177
                    main group molecular entity 24177
                      s-block molecular entity 23429
                        hydrogen molecular entity 23256
                          hydrides 21892
                            organic hydride 21360
                              organic fundamental parent 21360
                                hydrocarbon 21025
                                  cyclic hydrocarbon 19949
                                    arene 19946
                                      polycyclic arene 19636
                                        ortho-fused polycyclic arene 10167
                                          ortho-fused bicyclic arene 2362
                                            naphthalene 2309
                                              naphthol 187
                                                2-naphthol 33
                                                  tolnaftate 5
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