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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolnaftate
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Accession:CHEBI:9620 term browser browse the term
Definition:A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.
Synonyms:exact_synonym: O-2-naphthyl methyl(3-methylphenyl)carbamothioate
 related_synonym: 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate;   Formula=C19H17NOS;   InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3;   InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N;   Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester;   N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide;   O-2-Naphthyl m,N-dimethylthiocarbanilate;   SMILES=CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1;   Separin;   Tinactin;   Tolnaphthate;   m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester;   tolnaftato;   tolnaftatum
 xref: CAS:2398-96-1;   DrugBank:DB00525;   Drug_Central:3617;   HMDB:HMDB0005005;   KEGG:D00381;   LINCS:LSM-5554
 xref_mesh: MESH:D014047
 xref: PMID:20347664;   PMID:2061794;   PMID:20635527;   PMID:21565546;   PMID:22125963;   PMID:24706116;   PMID:3509341;   PMID:4568708;   PMID:5319027;   PMID:5705341;   PMID:5745067;   PMID:5847820;   PMID:5856396;   PMID:5952516;   PMID:697362;   Patent:US2010035939;   Patent:WO2010037089;   Reaxys:2752620;   Wikipedia:Tolnaftate


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tolnaftate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI-Kruppel family member GLI1 multiple interactions ISO
EXP
Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr10:127,329,882...127,341,579
Ensembl chr10:127,329,882...127,341,974
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Tolnaftate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533, PMID:15284827 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533, PMID:15284827 NCBI chr11:53,720,794...53,725,103
Ensembl chr11:53,720,794...53,725,106
JBrowse link
G Shh sonic hedgehog multiple interactions ISO
EXP
Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 5:28,456,840...28,467,101
Ensembl chr 5:28,456,815...28,467,256
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21530
    role 21508
      biological role 21507
        aetiopathogenetic role 20594
          genotoxin 18218
            2-naphthol 35
              tolnaftate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 21530
    subatomic particle 21516
      composite particle 21516
        hadron 21516
          baryon 21516
            nucleon 21516
              atomic nucleus 21516
                atom 21516
                  main group element atom 21417
                    main group molecular entity 21417
                      s-block molecular entity 20934
                        hydrogen molecular entity 20859
                          hydrides 20088
                            organic hydride 19582
                              organic fundamental parent 19582
                                hydrocarbon 19416
                                  cyclic hydrocarbon 17883
                                    arene 17879
                                      polycyclic arene 17659
                                        ortho-fused polycyclic arene 9904
                                          ortho-fused bicyclic arene 2383
                                            naphthalene 2330
                                              naphthol 186
                                                2-naphthol 35
                                                  tolnaftate 5
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