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ONTOLOGY REPORT - ANNOTATIONS


Term:trichlormethiazide
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Accession:CHEBI:9683 term browser browse the term
Definition:A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.
Synonyms:exact_synonym: 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
 related_synonym: Formula=C8H8Cl3N3O4S2;   InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16);   InChIKey=LMJSLTNSBFUCMU-UHFFFAOYSA-N;   SMILES=C12=C(NC(C(Cl)Cl)NS1(=O)=O)C=C(Cl)C(=C2)S(N)(=O)=O;   hydrotrichlorothiazide;   trichlormethiazidum;   triclormetiazida
 xref: CAS:133-67-5 "ChemIDplus";   CAS:133-67-5 "KEGG COMPOUND";   DrugBank:DB01021;   Drug_Central:2733 "DrugCentral";   KEGG:C07767;   KEGG:D00658;   LINCS:LSM-4383
 xref_mesh: MESH:D014237
 xref: PMID:21605415 "Europe PMC";   PMID:24678944 "Europe PMC";   PMID:25692026 "Europe PMC";   PMID:25938807 "Europe PMC";   PMID:28089902 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:29438107 "Europe PMC";   Wikipedia:Trichlormethiazide


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trichlormethiazide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc12a7 solute carrier family 12 member 7 JBrowse link 1 32,086,755 32,167,950 RGD:6480464
G Slc47a1 solute carrier family 47 member 1 JBrowse link 10 47,631,425 47,685,379 RGD:6480464
G Slc47a2 solute carrier family 47 member 2 JBrowse link 10 47,587,909 47,631,373 RGD:6480464
G Tpmt thiopurine S-methyltransferase JBrowse link 17 18,029,090 18,047,716 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19688
      biological role 19686
        antimicrobial agent 17215
          sulfonamide antibiotic 195
            trichlormethiazide 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19737
      composite particle 19737
        hadron 19737
          baryon 19737
            nucleon 19737
              atomic nucleus 19737
                atom 19737
                  main group element atom 19622
                    p-block element atom 19622
                      chalcogen 19334
                        oxygen atom 19295
                          oxygen molecular entity 19295
                            hydroxides 19048
                              oxoacid 18111
                                chalcogen oxoacid 11399
                                  sulfur oxoacid 10990
                                    sulfonic acid 7241
                                      sulfonic acid derivative 7241
                                        sulfonamide 3120
                                          sulfonamide antibiotic 195
                                            trichlormethiazide 4
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