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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:9737 term browser browse the term
Definition:A quinazoline that has formula C19H23N5O3.
Synonyms:related_synonym: 2,4-diamino-5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazolin-1-ium;   CI-898;   Formula=C19H23N5O3;   Formula=C19H24N5O3;   InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)/p+1;   InChIKey=NOYPYLRCIDNJJB-UHFFFAOYSA-O;   JB-11;   SMILES=CC1=C2C(=CC=C1CNC3=CC(OC)=C(C(=C3)OC)OC)N=C(N=C2N)N;   trimetrexate glucuronate;   trimetrexate hydrate
 alt_id: CHEBI:46138
 xref: CAS:52128-35-5;   Drug_Central:2757;   KEGG:C11154;   KEGG:D06238
 xref_mesh: MESH:D016597
 xref: PDBeChem:TMQ

show annotations for term's descendants           Sort by:
trimetrexate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase decreases response to substance ISO DHFR protein polymorphism results in decreased susceptibility to Trimetrexate CTD PMID:12872145 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases response to substance EXP GSTA3 protein results in decreased susceptibility to Trimetrexate CTD PMID:12872145 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS gene mutant form results in increased susceptibility to Trimetrexate CTD PMID:24688052 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Slc19a1 solute carrier family 19 member 1 decreases response to substance ISO SLC19A1 protein results in decreased susceptibility to Trimetrexate CTD PMID:12396629 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antifungal drug 5138
              trimetrexate 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      p-block molecular entity 19672
                        carbon group molecular entity 19574
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      quinazolines 464
                                        trimetrexate 3
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