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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ursodeoxycholic acid
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Accession:CHEBI:9907 term browser browse the term
Definition:A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Synonyms:related_synonym: (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid;   3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid;   Actigall;   Formula=C24H40O4;   InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1;   InChIKey=RUDATBOHQWOJDD-UZVSRGJWSA-N;   SMILES=[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])CC[C@]3(C)[C@]([H])(CC[C@@]3([H])[C@]1([H])[C@@H](O)C2)[C@H](C)CCC(O)=O;   Ursodeoxycholate;   Ursodiol
 xref: Beilstein:3219888;   CAS:128-13-2;   DrugBank:DB01586;   Drug_Central:2797;   HMDB:HMDB0000946;   KEGG:C07880;   KEGG:D00734;   LINCS:LSM-6555;   LIPID_MAPS_instance:LMST04010033
 xref_mesh: MESH:D014580
 xref: PMID:14989050;   PMID:17489439;   PMID:24816727;   Reaxys:3219888;   Wikipedia:Ursodiol
 cyclic_relationship: is_conjugate_acid_of CHEBI:78604


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ursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of AADAT mRNA CTD PMID:15885361 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 increases expression
decreases expression
multiple interactions
ISO
EXP
Ursodeoxycholic Acid results in increased expression of ABCB11 mRNA; Ursodeoxycholic Acid results in increased expression of ABCB11 protein
Ursodeoxycholic Acid results in decreased expression of ABCB11 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]
CTD PMID:11438506, PMID:12187295, PMID:14684751, PMID:25055961, PMID:25418378, PMID:25582706, PMID:27743861, PMID:32198087 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO
EXP
Ursodeoxycholic Acid results in increased expression of ABCB1 mRNA
Ursodeoxycholic Acid results in increased expression of ABCB1A mRNA
CTD PMID:15885361, PMID:16678547 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Ursodeoxycholic Acid results in increased expression of ABCB4 mRNA CTD PMID:25582706 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
EXP
ISO
Ursodeoxycholic Acid results in increased expression of ABCC1 mRNA
Ursodeoxycholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
CTD PMID:16101123, PMID:16764892 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
increases activity
affects expression
ISO
EXP
Ursodeoxycholic Acid results in increased expression of ABCC2; Ursodeoxycholic Acid results in increased expression of ABCC2 protein
Ursodeoxycholic Acid results in increased expression of ABCC2 mRNA; Ursodeoxycholic Acid results in increased expression of ABCC2 protein
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 protein]
Ursodeoxycholic Acid results in increased activity of ABCC2 protein
ABCC2 affects the reaction [Ursodeoxycholic Acid results in increased secretion of Nitric Oxide]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC2 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased activity of ABCC2 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; Ursodeoxycholic Acid promotes the reaction [ABCC2 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]
Ursodeoxycholic Acid affects the expression of ABCC2 mRNA; Ursodeoxycholic Acid affects the expression of ABCC2 protein
CTD PMID:11438506, PMID:12606635, PMID:12971955, PMID:15843489, PMID:15956029, PMID:16952291, PMID:18687751, PMID:19067394, PMID:20683964, PMID:25418378, PMID:25582706, PMID:27743861, PMID:32198087 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
affects expression
ISO
EXP
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 protein]
Ursodeoxycholic Acid results in increased expression of ABCC3 mRNA; Ursodeoxycholic Acid results in increased expression of ABCC3 protein
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCC3 protein]; Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC3 promoter]
Ursodeoxycholic Acid affects the expression of ABCC3 protein
CTD PMID:12971955, PMID:16472600, PMID:16764892, PMID:18687751, PMID:25055961, PMID:25418378, PMID:25582706 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression
affects expression
ISO
EXP
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 protein]
Ursodeoxycholic Acid results in increased expression of ABCC4 mRNA; Ursodeoxycholic Acid results in increased expression of ABCC4 protein
Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC4 promoter]
Ursodeoxycholic Acid affects the expression of ABCC4 protein
CTD PMID:16472600, PMID:18687751, PMID:25582706 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression ISO Ursodeoxycholic Acid results in increased expression of ABCG5 mRNA CTD PMID:25582706 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO Ursodeoxycholic Acid results in increased expression of ABCG8 mRNA CTD PMID:25582706 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of ACTN1 mRNA CTD PMID:15885361 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression
increases secretion
multiple interactions
ISO Ursodeoxycholic Acid results in increased expression of AHR mRNA
AHR gene mutant form results in increased secretion of Ursodeoxycholic Acid
AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Ursodeoxycholic Acid]
CTD PMID:18687751, PMID:29452137, PMID:32679164 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP Ursodeoxycholic Acid results in increased expression of AKR1B8 mRNA CTD PMID:15885361 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
decreases activity
ISO Ursodeoxycholic Acid inhibits the reaction [[AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone]
Ursodeoxycholic Acid results in decreased activity of AKR1C2 protein
CTD PMID:8573067, PMID:12604236, PMID:23261716 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Ursodeoxycholic Acid results in decreased activity of AKR1C3 protein CTD PMID:12604236 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:19073151 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ankrd28 ankyrin repeat domain 28 affects expression ISO Ursodeoxycholic Acid affects the expression of ANKRD28 mRNA CTD PMID:18422935 NCBI chr16:7,816,876...7,879,023
Ensembl chr16:7,818,667...7,928,518
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 affects expression ISO Ursodeoxycholic Acid affects the expression of AP2M1 mRNA CTD PMID:18422935 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of APAF1 mRNA; Ursodeoxycholic Acid results in decreased expression of APAF1 protein CTD PMID:15885361 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apoa1 apolipoprotein A1 increases expression ISO Ursodeoxycholic Acid results in increased expression of APOA1 mRNA CTD PMID:15115973 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apom apolipoprotein M multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]; Ursodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM protein] CTD PMID:22160096 NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073
JBrowse link
G Aqp8 aquaporin 8 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of AQP8 mRNA CTD PMID:15885361 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676
JBrowse link
G Arg1 arginase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of ARG1 mRNA CTD PMID:15885361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of ARL1 mRNA CTD PMID:15885361 NCBI chr 7:29,282,411...29,293,455
Ensembl chr 7:29,282,305...29,293,399
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of ARNT protein] CTD PMID:14761680 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Atf4 activating transcription factor 4 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of ATF4 mRNA CTD PMID:24312631 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of ATP8B1 mRNA CTD PMID:25582706 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
decreases expression
ISO
EXP
Ursodeoxycholic Acid results in increased expression of BAX
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; triciribine inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased expression of and affects the localization of BAX protein]
Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]
Ursodeoxycholic Acid results in decreased expression of BAX protein
Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [Okadaic Acid results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of and results in increased localization of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX protein]
CTD PMID:9562975, PMID:10510466, PMID:14514686, PMID:15970352, PMID:17461466, PMID:17881359, PMID:20137712, PMID:21419764, PMID:22178905, PMID:25502462 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in decreased expression of BCL2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 protein]
Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]
Ursodeoxycholic Acid results in decreased expression of BCL2 protein
CTD PMID:14514686, PMID:15970352, PMID:17461466, PMID:21419764, PMID:25502462 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bet1 Bet1 golgi vesicular membrane trafficking protein increases expression EXP Ursodeoxycholic Acid results in increased expression of BET1 mRNA CTD PMID:15885361 NCBI chr 4:29,082,368...29,092,638
Ensembl chr 4:29,082,365...29,092,753
JBrowse link
G Blvra biliverdin reductase A increases expression ISO
EXP
Ursodeoxycholic Acid results in increased expression of BLVRA mRNA
Ursodeoxycholic Acid results in increased expression of BLVRA mRNA; Ursodeoxycholic Acid results in increased expression of BLVRA protein
CTD PMID:18706437 NCBI chr 3:119,552,550...119,577,796
Ensembl chr 3:119,561,290...119,577,806
JBrowse link
G C4bpa complement component 4 binding protein, alpha affects expression ISO Ursodeoxycholic Acid affects the expression of C4BPA mRNA CTD PMID:18422935 NCBI chr13:47,342,090...47,377,580
Ensembl chr13:47,342,079...47,377,703
JBrowse link
G Capn2 calpain 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CAPN2 mRNA CTD PMID:15885361 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [CAR2 results in increased expression of IL2 mRNA] CTD PMID:15816485 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO
EXP
[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP3 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; pifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; TP53 mutant form inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP3 protein]; Ursodeoxycholic Acid promotes the reaction [irinotecan results in increased activity of CASP3 protein]; Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP3 protein
Ursodeoxycholic Acid results in decreased activity of CASP3 protein
Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]
CTD PMID:14514686, PMID:15222754, PMID:15970352, PMID:16310035, PMID:16432164, PMID:19728331, PMID:20137712, PMID:21146893, PMID:21362627, PMID:21419764, PMID:22178905, PMID:25502462 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP6 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; rottlerin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; Ursodeoxycholic Acid results in increased cleavage of and results in increased activity of CASP6 protein CTD PMID:21362627 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP7 protein]
Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP7 protein]; Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP7 protein]
CTD PMID:21146893, PMID:22178905 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO
EXP
[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of and results in increased activity of CASP8 protein; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; pifithrin inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; TP53 mutant form inhibits the reaction [[oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]; Ursodeoxycholic Acid promotes the reaction [irinotecan results in increased activity of CASP8 protein]
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP8 protein]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP8 protein]
CTD PMID:16432164, PMID:19728331, PMID:21146893, PMID:21362627, PMID:25502462 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [Nitroprusside results in increased activity of CASP9 protein]
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP9 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of CASP9 protein]
CTD PMID:22178905, PMID:25502462 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL2 mRNA]]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]
Ursodeoxycholic Acid results in increased expression of CCL2 mRNA
CTD PMID:21146893, PMID:24312631 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL5 mRNA]]
Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CCL5 mRNA]; Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased secretion of CCL5 protein]
CTD PMID:21146893 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CCN2 mRNA CTD PMID:15885361 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO
EXP
Ursodeoxycholic Acid results in decreased expression of CCND1 protein
Ursodeoxycholic Acid results in decreased expression of CCND1 mRNA; Ursodeoxycholic Acid results in decreased expression of CCND1 protein
Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of CCND1 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of CCND1 protein]
CTD PMID:12496057, PMID:15885361, PMID:17431217, PMID:17461466 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of CCND3 protein CTD PMID:17461466 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cct3 chaperonin containing TCP1 subunit 3 affects expression ISO Ursodeoxycholic Acid affects the expression of CCT3 mRNA CTD PMID:18422935 NCBI chr 2:187,669,051...187,693,610
Ensembl chr 2:187,668,796...187,693,610
JBrowse link
G Cct5 chaperonin containing TCP1 subunit 5 affects expression ISO Ursodeoxycholic Acid affects the expression of CCT5 mRNA CTD PMID:18422935 NCBI chr 2:84,667,578...84,678,730
Ensembl chr 2:84,667,633...84,678,790
JBrowse link
G Cd14 CD14 molecule increases expression EXP Ursodeoxycholic Acid results in increased expression of CD14 mRNA CTD PMID:15885361 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd248 CD248 molecule affects expression ISO Ursodeoxycholic Acid affects the expression of CD248 mRNA CTD PMID:18422935 NCBI chr 1:220,353,308...220,355,872
Ensembl chr 1:220,446,425...220,448,989
JBrowse link
G Cdh1 cadherin 1 multiple interactions
decreases expression
EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of CDH1 protein]
Ursodeoxycholic Acid results in decreased expression of CDH1 mRNA
CTD PMID:12496057, PMID:15885361 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh17 cadherin 17 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CDH17 mRNA CTD PMID:15885361 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of CEBPB] CTD PMID:18444174 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Ursodeoxycholic Acid results in increased expression of CEBPD mRNA CTD PMID:15885361 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO Ursodeoxycholic Acid analog results in increased expression of CFLAR protein CTD PMID:21146893 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CITED2 mRNA CTD PMID:15885361 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase affects expression ISO Ursodeoxycholic Acid affects the expression of CNP mRNA CTD PMID:18422935 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP Ursodeoxycholic Acid results in decreased expression of COL3A1 mRNA CTD PMID:18479249 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Crebbp CREB binding protein decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CREBBP mRNA CTD PMID:19493473 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cryab crystallin, alpha B decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CRYAB mRNA CTD PMID:15885361 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Cse1l chromosome segregation 1 like affects expression ISO Ursodeoxycholic Acid affects the expression of CSE1L mRNA CTD PMID:18422935 NCBI chr 3:163,664,074...163,702,074
Ensembl chr 3:163,664,136...163,702,060
JBrowse link
G Cspg4 chondroitin sulfate proteoglycan 4 affects expression ISO Ursodeoxycholic Acid affects the expression of CSPG4 mRNA CTD PMID:18422935 NCBI chr 8:61,532,465...61,567,510
Ensembl chr 8:61,532,465...61,567,510
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO Ursodeoxycholic Acid results in increased expression of CXCL1 mRNA CTD PMID:24312631 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP Ursodeoxycholic Acid results in increased expression of CXCL10 mRNA CTD PMID:15885361 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression
decreases secretion
ISO Ursodeoxycholic Acid results in decreased expression of CXCL2 mRNA; Ursodeoxycholic Acid results in decreased expression of CXCL2 protein
Ursodeoxycholic Acid results in decreased secretion of CXCL2 protein
CTD PMID:17888421 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Ursodeoxycholic Acid results in increased expression of CXCL1 mRNA CTD PMID:24312631 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [benzo(a)pyrene 7,8-dihydrodiol results in increased expression of CYP1A1 mRNA] CTD PMID:10706104 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of CYP26A1 mRNA CTD PMID:15885361 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid results in increased expression of CYP27A1 mRNA
Ursodeoxycholic Acid results in decreased expression of CYP27A1 mRNA
CTD PMID:16764892, PMID:25582706 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
affects expression
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP2B10 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP2B1 protein]
Ursodeoxycholic Acid affects the expression of CYP2B10 protein
CTD PMID:10453939, PMID:16472600, PMID:32198087 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CYP2B3 mRNA CTD PMID:15885361 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP2C11 protein] CTD PMID:10453939 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CYP2C12 mRNA CTD PMID:15885361 NCBI chr 1:258,709,726...258,766,873
Ensembl chr 1:258,709,721...258,766,881
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP2C6V1 protein] CTD PMID:10453939 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of CYP2C7 mRNA CTD PMID:15885361 NCBI chr 1:147,422,999...148,119,979
Ensembl chr 1:148,053,687...148,119,857
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP2E1 protein] CTD PMID:10453939 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of and results in decreased activity of CYP3A2 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP3A2 mRNA]
Ursodeoxycholic Acid results in increased expression of CYP3A2 mRNA
CTD PMID:10453939, PMID:19255942, PMID:32198087 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19255942 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in decreased expression of CYP4A1 protein] CTD PMID:10453939 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[Tretinoin co-treated with Ursodeoxycholic Acid] results in decreased expression of CYP7A1 mRNA; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of CYP7A1 mRNA]
Ursodeoxycholic Acid results in decreased expression of CYP7A1 mRNA
Ursodeoxycholic Acid results in increased expression of CYP7A1 mRNA
Tretinoin promotes the reaction [Ursodeoxycholic Acid results in decreased expression of CYP7A1 mRNA]; Ursodeoxycholic Acid promotes the reaction [Tretinoin results in decreased expression of CYP7A1 mRNA]
CTD PMID:14684751, PMID:16487557, PMID:16764892, PMID:20671298, PMID:21274875, PMID:25582706 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of CYP7B1 mRNA CTD PMID:20671298 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid results in increased expression of CYP8B1 mRNA
Ursodeoxycholic Acid results in decreased expression of CYP8B1 mRNA
CTD PMID:16764892, PMID:25582706 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dap3 death associated protein 3 affects expression ISO Ursodeoxycholic Acid affects the expression of DAP3 mRNA CTD PMID:18422935 NCBI chr 2:188,225,607...188,255,324
Ensembl chr 2:188,225,613...188,252,725
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Ursodeoxycholic Acid results in increased expression of DDIT3 mRNA CTD PMID:15885361 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dhx9 DExH-box helicase 9 affects expression ISO Ursodeoxycholic Acid affects the expression of DHX9 mRNA CTD PMID:18422935 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase affects expression ISO Ursodeoxycholic Acid affects the expression of DLAT mRNA CTD PMID:18422935 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein multiple interactions
increases expression
ISO DLC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased activity of RHOA protein]
Ursodeoxycholic Acid results in increased expression of DLC1 protein
CTD PMID:21455586 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Dmgdh dimethylglycine dehydrogenase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of DMGDH mRNA CTD PMID:15885361 NCBI chr 2:23,289,376...23,370,360
Ensembl chr 2:23,289,374...23,370,477
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid results in increased expression of DNAJC3 mRNA
Ursodeoxycholic Acid results in decreased expression of DNAJC3 mRNA
CTD PMID:15885361, PMID:24312631 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dnase2b deoxyribonuclease 2 beta decreases expression EXP Ursodeoxycholic Acid results in decreased expression of DNASE2B mRNA CTD PMID:15885361 NCBI chr 2:252,436,363...252,475,506
Ensembl chr 2:252,436,332...252,451,999
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of DPP4 mRNA CTD PMID:15885361 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions
decreases expression
EXP NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein] CTD PMID:14514686, PMID:15222754 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of ECI1 mRNA CTD PMID:15885361 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of EDN1 mRNA; Ursodeoxycholic Acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of EDN2 protein CTD PMID:15691296 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of EGFR protein] CTD PMID:14747693 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of EGLN3 mRNA CTD PMID:15885361 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of EGR1 mRNA] CTD PMID:18590720 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 affects expression ISO Ursodeoxycholic Acid affects the expression of EIF1 mRNA CTD PMID:18422935 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]; Ursodeoxycholic Acid promotes the reaction [EP300 protein binds to SLC4A2 promoter] CTD PMID:18188457 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 affects expression ISO Ursodeoxycholic Acid affects the expression of ERMP1 mRNA CTD PMID:18422935 NCBI chr 1:247,784,830...247,821,771
Ensembl chr 1:247,787,582...247,821,728
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of FABP4 mRNA CTD PMID:24312631 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fabp6 fatty acid binding protein 6 multiple interactions
increases expression
ISO Ursodeoxycholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased expression of FABP6 mRNA]
Ursodeoxycholic Acid results in increased expression of FABP6 mRNA
CTD PMID:15935148, PMID:25582706 NCBI chr10:29,191,621...29,196,593
Ensembl chr10:29,191,623...29,196,563
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:21362627 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of FADS1 mRNA CTD PMID:15885361 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fads3 fatty acid desaturase 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of FADS3 mRNA CTD PMID:15885361 NCBI chr 1:226,091,774...226,108,332
Ensembl chr 1:226,091,774...226,108,332
JBrowse link
G Fam169a family with sequence similarity 169, member A affects expression ISO Ursodeoxycholic Acid affects the expression of FAM169A mRNA CTD PMID:18422935 NCBI chr 2:27,884,748...27,941,069
Ensembl chr 2:27,905,535...27,938,525
JBrowse link
G Fasn fatty acid synthase decreases expression EXP
ISO
Ursodeoxycholic Acid results in decreased expression of FASN mRNA CTD PMID:15885361, PMID:24312631 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions
increases expression
ISO Ursodeoxycholic Acid promotes the reaction [Tretinoin results in increased expression of FGF19 mRNA]
Ursodeoxycholic Acid results in increased expression of FGF15 mRNA
Ursodeoxycholic Acid results in increased expression of FGF19 mRNA
CTD PMID:21274875, PMID:25055961, PMID:25582706 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Fgg fibrinogen gamma chain affects expression ISO Ursodeoxycholic Acid affects the expression of FGG mRNA CTD PMID:18422935 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fgl1 fibrinogen-like 1 affects expression ISO Ursodeoxycholic Acid affects the expression of FGL1 mRNA CTD PMID:18422935 NCBI chr16:54,153,086...54,188,120
Ensembl chr16:54,153,054...54,188,181
JBrowse link
G Gamt guanidinoacetate N-methyltransferase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GAMT mRNA CTD PMID:15885361 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998
JBrowse link
G Gars glycyl-tRNA synthetase affects expression ISO Ursodeoxycholic Acid affects the expression of GARS1 mRNA CTD PMID:18422935 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gckr glucokinase regulator decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GCKR mRNA CTD PMID:15885361 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLC mRNA]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]
Ursodeoxycholic Acid results in increased expression of GCLC mRNA; Ursodeoxycholic Acid results in increased expression of GCLC protein
CTD PMID:18687751, PMID:19073151, PMID:20146260 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLM mRNA]; Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GCLM mRNA] CTD PMID:19073151 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of GPBAR1 mRNA CTD PMID:24312631 NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594
JBrowse link
G Gpnmb glycoprotein nmb decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GPNMB mRNA CTD PMID:15885361 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in increased activity of GPT protein] CTD PMID:15950962, PMID:27743861 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Grb14 growth factor receptor bound protein 14 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GRB14 mRNA CTD PMID:15885361 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Gss glutathione synthetase multiple interactions
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GSS mRNA]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA] CTD PMID:19073151, PMID:20146260 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression ISO Ursodeoxycholic Acid results in increased expression of GSTA2 mRNA CTD PMID:18687751 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GSTA5 mRNA CTD PMID:15885361 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression ISO Ursodeoxycholic Acid results in increased expression of GSTA2 mRNA CTD PMID:18687751 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of GSTM3 mRNA CTD PMID:15885361 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HAAO mRNA CTD PMID:15885361 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Hbp1 HMG-box transcription factor 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of HBP1 mRNA CTD PMID:15885361 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HDHD2 mRNA CTD PMID:15885361 NCBI chr18:73,226,630...73,278,062
Ensembl chr18:73,226,630...73,278,337
JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases expression
ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF mRNA]; Ursodeoxycholic Acid inhibits the reaction [Cholera Toxin results in increased expression of HGF protein]; Ursodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF mRNA]; Ursodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HGF protein]
Ursodeoxycholic Acid results in increased expression of HGF mRNA
CTD PMID:11983124, PMID:15802798 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases activity EXP Ursodeoxycholic Acid results in decreased activity of HMGCR protein CTD PMID:6832710 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HMGCS2 mRNA CTD PMID:15885361 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]; Ursodeoxycholic Acid promotes the reaction [HNF1A protein binds to SLC4A2 promoter] CTD PMID:18188457 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hnf1b HNF1 homeobox B multiple interactions ISO [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form] CTD PMID:18188457 NCBI chr10:71,159,863...71,218,902
Ensembl chr10:71,159,869...71,218,902
JBrowse link
G Hpn hepsin decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HPN mRNA CTD PMID:15885361 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of HRAS protein] CTD PMID:12839936 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hrg histidine-rich glycoprotein decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HRG mRNA CTD PMID:15885361 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 multiple interactions
increases abundance
ISO [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid
HSD11B1 gene mutant form results in increased abundance of Ursodeoxycholic Acid
CTD PMID:21453287, PMID:25061560 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of HSD17B6 mRNA CTD PMID:15885361 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of HSPA5 mRNA CTD PMID:24312631 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IFNG protein]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD PMID:8568266, PMID:12620498, PMID:32198087 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP Ursodeoxycholic Acid results in decreased expression of IGFALS mRNA CTD PMID:15885361 NCBI chr10:14,240,308...14,243,554
Ensembl chr10:14,240,219...14,243,597
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of IGFBP1 mRNA CTD PMID:15885361 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases abundance
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of IL10 protein]
IL10 gene mutant form results in decreased abundance of Ursodeoxycholic Acid
CTD PMID:25502462, PMID:27580383 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
EXP Tretinoin inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of IL1B mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of IL1B protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of IL1B mRNA] CTD PMID:21274875, PMID:25502462, PMID:32198087 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [CAR2 results in increased expression of IL2 mRNA] CTD PMID:15816485 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion
ISO
EXP
Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of IL6 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased secretion of IL6 protein]]
Ursodeoxycholic Acid results in decreased secretion of IL6 protein
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL6 protein]
CTD PMID:17888421, PMID:18590720, PMID:21146893 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 affects expression ISO Ursodeoxycholic Acid affects the expression of IMPDH2 mRNA CTD PMID:18422935 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
JBrowse link
G Irs2 insulin receptor substrate 2 increases expression EXP Ursodeoxycholic Acid results in increased expression of IRS2 mRNA CTD PMID:15885361 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Ivl involucrin decreases expression ISO Ursodeoxycholic Acid results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Klf15 Kruppel-like factor 15 increases expression EXP Ursodeoxycholic Acid results in increased expression of KLF15 mRNA CTD PMID:15885361 NCBI chr 4:122,364,688...122,377,690
Ensembl chr 4:122,365,093...122,377,659
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased mutagenesis of KRAS gene] CTD PMID:12839936 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt18 keratin 18 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of KRT18 mRNA CTD PMID:15885361 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of KRT19 mRNA] CTD PMID:21274875 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Lgals5 galectin 5 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of LGALS5 mRNA CTD PMID:15885361 NCBI chr10:66,226,015...66,229,293
Ensembl chr10:66,225,995...66,229,311
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of LMAN1 mRNA CTD PMID:15885361 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317
JBrowse link
G Lox lysyl oxidase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of LOX mRNA CTD PMID:15885361 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Maf MAF bZIP transcription factor multiple interactions ISO S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein] CTD PMID:20146260 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Mafg MAF bZIP transcription factor G multiple interactions ISO S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein] CTD PMID:20146260 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MAGI3 mRNA CTD PMID:15885361 NCBI chr 2:206,499,467...206,699,105
Ensembl chr 2:206,499,463...206,699,105
JBrowse link
G Maob monoamine oxidase B decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MAOB mRNA CTD PMID:15885361 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:14747693, PMID:24312631 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:14747693, PMID:24312631 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mbp myelin basic protein affects expression ISO Ursodeoxycholic Acid affects the expression of MBP mRNA CTD PMID:18422935 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Ursodeoxycholic Acid analog results in increased expression of MCL1 protein CTD PMID:21146893 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
EXP
ISO
[Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein; MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid affects the localization of TP53 protein]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]; Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]
Ursodeoxycholic Acid results in increased expression of MDM2 mRNA
MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein]
CTD PMID:14514686, PMID:15222754, PMID:15885361, PMID:17881359, PMID:20807506 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression EXP Ursodeoxycholic Acid results in increased expression of MET mRNA CTD PMID:11983124 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mgll monoglyceride lipase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MGLL mRNA CTD PMID:15885361 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mir21 microRNA 21 increases expression ISO
EXP
Ursodeoxycholic Acid results in increased expression of MIR21 mRNA CTD PMID:20689055 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of MMP2 mRNA] CTD PMID:21274875 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mpo myeloperoxidase decreases activity ISO Ursodeoxycholic Acid results in decreased activity of MPO protein CTD PMID:17888421 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Msn moesin decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MSN mRNA CTD PMID:15885361 NCBI chr  X:65,226,834...65,294,192
Ensembl chr  X:65,226,748...65,295,810
JBrowse link
G Mt2A metallothionein 2A increases expression EXP Ursodeoxycholic Acid results in increased expression of MT2A mRNA CTD PMID:10491327 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myh9 myosin, heavy chain 9 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of MYH9 mRNA CTD PMID:15885361 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 affects expression ISO Ursodeoxycholic Acid affects the expression of NAP1L1 mRNA CTD PMID:18422935 NCBI chr 7:54,213,305...54,237,880
Ensembl chr 7:54,213,319...54,236,625
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases localization
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased localization of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]
Ursodeoxycholic Acid results in increased expression of NFE2L2 mRNA
Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC3 promoter]; Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC4 promoter]; Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Ursodeoxycholic Acid results in increased activity of and results in increased localization of NFE2L2 protein
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC2 protein]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC3 protein]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 protein]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR1I2 mRNA]; NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA]
CTD PMID:18687751, PMID:19073151, PMID:20146260, PMID:25582706 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of NFKB1 mRNA]]
Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]
CTD PMID:21146893, PMID:25502462 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation ISO Ursodeoxycholic Acid results in decreased degradation of NFKBIA protein CTD PMID:15473667 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
decreases expression
EXP
ISO
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NOS2 protein]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of NOS2 protein]
Ursodeoxycholic Acid results in increased expression of NOS2
Ursodeoxycholic Acid results in decreased expression of NOS2 protein
Ursodeoxycholic Acid inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NOS2 mRNA]
CTD PMID:12496057, PMID:12620498, PMID:17438113, PMID:18479249, PMID:18590720, PMID:20683964 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP
ISO
Ursodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to NQO1 promoter]
Ursodeoxycholic Acid results in increased expression of NQO1 mRNA; Ursodeoxycholic Acid results in increased expression of NQO1 protein
CTD PMID:18687751, PMID:25582706 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression EXP
ISO
Ursodeoxycholic Acid results in increased expression of NR0B2 mRNA CTD PMID:16764892, PMID:18706437, PMID:21274875, PMID:25055961, PMID:25582706 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity
multiple interactions
increases expression
decreases expression
affects binding
ISO
EXP
Ursodeoxycholic Acid results in increased activity of NR1H4 protein
ursodeoxycholic acid inhibits the reaction [1-naphthyl isothiocyanate decreases expression of nr1h4 mRNA and protein in rat liver]; ursodeoxycholic acid increases expression of nr1h4 mRNA and protein in rat embryonic liver cells
Chenodeoxycholic Acid inhibits the reaction [Ursodeoxycholic Acid binds to NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Ursodeoxycholic Acid results in increased expression of NR1H4 mRNA
Ursodeoxycholic Acid results in decreased expression of NR1H4 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in increased expression of NR1H4 mRNA]
Ursodeoxycholic Acid results in increased expression of NR1H4 mRNA; Ursodeoxycholic Acid results in increased expression of NR1H4 protein
CTD PMID:14684751, PMID:15935148, PMID:17567710, PMID:18706437, PMID:21274875, PMID:24312631, PMID:25257666, PMID:25582706, PMID:27743861, PMID:32198087, PMID:29235094 RGD:15042872 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions
ISO Ursodeoxycholic Acid results in increased expression of NR1I2 mRNA
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR1I2 mRNA]
CTD PMID:18687751, PMID:18706437, PMID:25582706 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases localization
affects localization
increases expression
increases activity
EXP
ISO
[Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C1 protein; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 protein]; Ursodeoxycholic Acid results in increased expression of and results in increased localization of NR3C1 protein
Ursodeoxycholic Acid results in increased localization of NR3C1 protein
[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [NR3C1 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased localization of NR3C1 protein; [Ursodeoxycholic Acid co-treated with NR3C1] results in decreased expression of HLA-DRA mRNA
Ursodeoxycholic Acid affects the localization of NR3C1 protein
Ursodeoxycholic Acid results in increased expression of NR3C1 mRNA
Ursodeoxycholic Acid results in increased activity of NR3C1 protein
CTD PMID:8568266, PMID:15222754, PMID:15674094, PMID:16175607, PMID:18188457, PMID:21158453 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions
increases expression
increases localization
EXP [Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]
Ursodeoxycholic Acid results in increased expression of NR3C2 mRNA
Ursodeoxycholic Acid results in increased localization of NR3C2 protein
CTD PMID:15222754 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 increases expression
multiple interactions
ISO Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA
NFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of NR5A2 mRNA]
CTD PMID:18687751 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G Nucb2 nucleobindin 2 increases expression EXP Ursodeoxycholic Acid results in increased expression of NUCB2 mRNA CTD PMID:15885361 NCBI chr 1:185,106,773...185,143,278
Ensembl chr 1:185,104,656...185,143,272
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Ursodeoxycholic Acid results in increased expression of NUPR1 mRNA CTD PMID:15885361 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oaf out at first homolog affects expression ISO Ursodeoxycholic Acid affects the expression of OAF mRNA CTD PMID:18422935 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Oplah 5-oxoprolinase (ATP-hydrolysing) decreases expression EXP Ursodeoxycholic Acid results in decreased expression of OPLAH mRNA CTD PMID:15885361 NCBI chr 7:117,353,951...117,394,205
Ensembl chr 7:117,353,786...117,369,159
JBrowse link
G Otc ornithine carbamoyltransferase decreases expression EXP Ursodeoxycholic Acid results in decreased expression of OTC mRNA CTD PMID:15885361 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased cleavage of PARP1 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; FADD mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein]; TNFRSF10B mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:19728331, PMID:21362627 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PCNA protein] CTD PMID:17438113 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Perp p53 apoptosis effector related to PMP22 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of PERP mRNA CTD PMID:15885361 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Pgr progesterone receptor multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [[Ethinyl Estradiol co-treated with Progesterone] results in increased expression of PGR protein] CTD PMID:14728856 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Ursodeoxycholic Acid results in decreased expression of PKLR mRNA CTD PMID:15885361 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions EXP Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of PLA2G2A protein]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A mRNA]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A protein] CTD PMID:10025872 NCBI chr 5:157,282,650...157,285,295
Ensembl chr 5:157,282,669...157,285,328
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Ursodeoxycholic Acid results in decreased expression of PPARG mRNA CTD PMID:24312631 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Ursodeoxycholic Acid results in increased expression of PRDX1 mRNA; Ursodeoxycholic Acid results in increased expression of PRDX1 protein CTD PMID:18687751 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prkcb protein kinase C, beta increases activity ISO Ursodeoxycholic Acid results in increased activity of PRKCB protein CTD PMID:7705931 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
increases localization
increases response to substance
ISO Acetylcysteine inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]; Butylated Hydroxyanisole inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]; diphenyleneiodonium inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]; methyl-beta-cyclodextrin inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]
PRKCD results in increased susceptibility to Ursodeoxycholic Acid
CTD PMID:21362627 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prnp prion protein decreases expression EXP Ursodeoxycholic Acid results in decreased expression of PRNP mRNA CTD PMID:15885361 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of PTGS2]
Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PTGS2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PTGS2 protein]
CTD PMID:12496057, PMID:12839936, PMID:18444174 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptma prothymosin alpha increases expression EXP Ursodeoxycholic Acid results in increased expression of PTMA mRNA CTD PMID:15885361 NCBI chr 9:93,545,396...93,549,436
Ensembl chr 9:93,545,396...93,549,436
JBrowse link
G Rab6a RAB6A, member RAS oncogene family increases expression EXP Ursodeoxycholic Acid results in increased expression of RAB6A mRNA CTD PMID:15885361 NCBI chr 1:165,624,973...165,664,201
Ensembl chr 1:165,625,058...165,664,192
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions
affects expression
ISO RAC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased expression of TNFRSF10B]
Ursodeoxycholic Acid affects the expression of RAC1 mRNA
CTD PMID:18422935, PMID:21362627 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased phosphorylation of and results in increased activity of RAF1 protein] CTD PMID:14747693 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Ursodeoxycholic Acid results in decreased expression of RB1 protein modified form CTD PMID:17461466 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase affects expression ISO Ursodeoxycholic Acid affects the expression of RBBP6 mRNA CTD PMID:18422935 NCBI chr 1:192,933,264...192,965,160
Ensembl chr 1:192,933,540...192,965,158
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase affects expression ISO Ursodeoxycholic Acid affects the expression of RFFL mRNA CTD PMID:18422935 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G Rhoa ras homolog family member A multiple interactions
decreases activity
ISO DLC1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in decreased activity of RHOA protein] CTD PMID:21455586 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhobtb3 Rho-related BTB domain containing 3 affects expression ISO Ursodeoxycholic Acid affects the expression of RHOBTB3 mRNA CTD PMID:18422935 NCBI chr 2:2,627,655...2,683,305
Ensembl chr 2:2,627,393...2,683,116
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased activity of CASP8 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP3 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of CASP6 protein]; RIPK1 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased cleavage of PARP1 protein] CTD PMID:21362627 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Rnf138 ring finger protein 138 increases expression EXP Ursodeoxycholic Acid results in increased expression of RNF138 mRNA CTD PMID:15885361 NCBI chr18:15,146,925...15,167,361 JBrowse link
G Rnf181 ring finger protein 181 increases expression EXP Ursodeoxycholic Acid results in increased expression of RNF181 mRNA CTD PMID:15885361 NCBI chr 4:100,222,087...100,228,809
Ensembl chr 4:100,222,106...100,228,809
JBrowse link
G Rpl10 ribosomal protein L10 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL10 mRNA CTD PMID:18422935 NCBI chr  X:156,438,251...156,440,461
Ensembl chr  X:156,438,251...156,440,461
JBrowse link
G Rpl27 ribosomal protein L27 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL27 mRNA CTD PMID:18422935 NCBI chr10:89,352,864...89,356,563
Ensembl chr10:89,352,835...89,356,547
JBrowse link
G Rpl32 ribosomal protein L32 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL32 mRNA CTD PMID:18422935 NCBI chr 4:147,715,480...147,719,044
Ensembl chr 6:145,777,318...145,777,767
Ensembl chr 4:145,777,318...145,777,767
JBrowse link
G Rpl35a ribosomal protein L35a affects expression ISO Ursodeoxycholic Acid affects the expression of RPL35A mRNA CTD PMID:18422935 NCBI chr11:70,963,223...70,967,146
Ensembl chr12:7,186,473...7,186,873
Ensembl chr 5:7,186,473...7,186,873
Ensembl chr 1:7,186,473...7,186,873
Ensembl chr 6:7,186,473...7,186,873
Ensembl chr12:7,186,473...7,186,873
JBrowse link
G Rpl39l ribosomal protein L39-like affects expression ISO Ursodeoxycholic Acid affects the expression of RPL39L mRNA CTD PMID:18422935 NCBI chr10:5,529,580...5,533,695
Ensembl chr10:5,529,589...5,533,695
JBrowse link
G Rpl6 ribosomal protein L6 affects expression ISO Ursodeoxycholic Acid affects the expression of RPL6 mRNA CTD PMID:18422935 NCBI chr12:40,877,578...40,882,032
Ensembl chr12:40,877,613...40,881,124
JBrowse link
G Rplp2 ribosomal protein lateral stalk subunit P2 affects expression ISO Ursodeoxycholic Acid affects the expression of RPLP2 mRNA CTD PMID:18422935 NCBI chr 1:214,428,280...214,430,551
Ensembl chr 1:214,428,526...214,430,515
JBrowse link
G Rps13 ribosomal protein S13 affects expression ISO Ursodeoxycholic Acid affects the expression of RPS13 mRNA CTD PMID:18422935 NCBI chr 1:185,328,902...185,331,332
Ensembl chr 3:4,341,249...4,341,771
JBrowse link
G Rps27l ribosomal protein S27-like affects expression ISO Ursodeoxycholic Acid affects the expression of RPS27L mRNA CTD PMID:18422935 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Rps28 ribosomal protein S28 affects expression ISO Ursodeoxycholic Acid affects the expression of RPS28 mRNA CTD PMID:18422935 NCBI chr 7:18,682,071...18,683,440
Ensembl chr 7:18,682,071...18,683,440
JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions
increases expression
ISO [Ursodeoxycholic Acid co-treated with NR3C1] results in decreased expression of HLA-DRA mRNA; Ursodeoxycholic Acid inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]
Ursodeoxycholic Acid results in increased expression of HLA-DRA mRNA
CTD PMID:8568266 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of S100A6 mRNA CTD PMID:15885361 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Samd4b sterile alpha motif domain containing 4B affects expression ISO Ursodeoxycholic Acid affects the expression of SAMD4B mRNA CTD PMID:18422935 NCBI chr 1:85,324,017...85,362,266
Ensembl chr 1:85,324,043...85,362,241
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO Ursodeoxycholic Acid results in decreased expression of SCD mRNA CTD PMID:24312631 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sct secretin multiple interactions
increases activity
increases response to substance
EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Colchicine inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Colchicine inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; Go 6976 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; Go 6976 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; SLC4A2 affects the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; U 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; U 0126 inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; U 0126 inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
SCT results in increased susceptibility to Ursodeoxycholic Acid; SCT results in increased susceptibility to Ursodeoxycholic Acid analog
CTD PMID:22194894 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of SERP1 mRNA CTD PMID:15885361 NCBI chr 2:148,718,279...148,722,263
Ensembl chr 2:148,718,280...148,722,263
JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 affects expression ISO Ursodeoxycholic Acid affects the expression of SF3B1 mRNA CTD PMID:18422935 NCBI chr 9:61,594,620...61,634,510
Ensembl chr 9:61,594,620...61,634,510
JBrowse link
G Shld2 shieldin complex subunit 2 affects expression ISO Ursodeoxycholic Acid affects the expression of SHLD2 mRNA CTD PMID:18422935 NCBI chr16:10,570,307...10,661,528
Ensembl chr16:10,570,314...10,661,528
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
increases expression
affects expression
EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]
Ursodeoxycholic Acid results in increased expression of SLC10A1 protein
Ursodeoxycholic Acid affects the expression of SLC10A1 mRNA
Ursodeoxycholic Acid results in increased expression of SLC10A1 mRNA
CTD PMID:16487557, PMID:16764892, PMID:25582706, PMID:27743861, PMID:32198087 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP
ISO
Ursodeoxycholic Acid results in increased expression of SLC10A2 mRNA CTD PMID:16764892, PMID:25582706 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC22A8 mRNA CTD PMID:15885361 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc23a1 solute carrier family 23 member 1 increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC23A1 mRNA CTD PMID:18706437 NCBI chr18:28,413,910...28,428,133
Ensembl chr18:28,414,009...28,428,117
JBrowse link
G Slc23a2 solute carrier family 23 member 2 increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC23A2 mRNA CTD PMID:18706437 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
G Slc25a5 solute carrier family 25 member 5 affects expression ISO Ursodeoxycholic Acid affects the expression of SLC25A5 mRNA CTD PMID:18422935 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc26a1 solute carrier family 26 member 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC26A1 mRNA CTD PMID:15885361 NCBI chr14:2,050,805...2,056,091
Ensembl chr14:2,050,483...2,056,089
JBrowse link
G Slc27a5 solute carrier family 27 member 5 multiple interactions ISO Ursodeoxycholic Acid inhibits the reaction [SLC27A5 protein results in increased uptake of Fatty Acids] CTD PMID:22531947 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186
JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC28A2 mRNA CTD PMID:15885361 NCBI chr 3:114,355,003...114,647,382
Ensembl chr 3:114,355,798...114,647,382
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SLC2A2 mRNA CTD PMID:15885361 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions EXP
ISO
SLC4A2 affects the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
[Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to NR3C1 protein binds to HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [EP300 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to NR3C1 protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1A protein binds to SLC4A2 promoter]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [HNF1B protein binds to NR3C1 protein binds to EP300 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] promotes the reaction [NR3C1 protein binds to SLC4A2 promoter alternative form]; [Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased activity of SLC4A2 protein; [Ursodeoxycholic Acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form; Ursodeoxycholic Acid promotes the reaction [EP300 protein binds to SLC4A2 promoter]; Ursodeoxycholic Acid promotes the reaction [HNF1A protein binds to SLC4A2 promoter]
CTD PMID:18188457, PMID:22194894 NCBI chr 4:7,264,677...7,282,355
Ensembl chr 4:7,264,683...7,281,223
JBrowse link
G Slc51a solute carrier family 51 subunit alpha increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC51A mRNA CTD PMID:25055961, PMID:25582706 NCBI chr11:71,533,078...71,547,476
Ensembl chr11:71,533,078...71,547,476
JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression ISO Ursodeoxycholic Acid results in increased expression of SLC51B mRNA CTD PMID:25055961, PMID:25582706 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression
multiple interactions
increases expression
ISO
EXP
Ursodeoxycholic Acid affects the expression of SLCO1A4 mRNA
Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLCO1A2 mRNA]
Ursodeoxycholic Acid results in increased expression of SLCO1A4 mRNA
CTD PMID:18687751, PMID:25582706, PMID:27743861 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression
multiple interactions
increases uptake
increases expression
EXP
ISO
Ursodeoxycholic Acid results in decreased expression of SLCO1B3 mRNA
Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite]
SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid; SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite
Ursodeoxycholic Acid results in increased expression of SLCO1B2 mRNA
CTD PMID:15885361, PMID:16534140, PMID:25582706, PMID:31299240 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Smad3 SMAD family member 3 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SMAD3 mRNA; Ursodeoxycholic Acid results in decreased expression of SMAD3 protein CTD PMID:19493473 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad7 SMAD family member 7 increases expression EXP Ursodeoxycholic Acid results in increased expression of SMAD7 mRNA; Ursodeoxycholic Acid results in increased expression of SMAD7 protein CTD PMID:19493473 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Soat1 sterol O-acyltransferase 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of SOAT1 mRNA CTD PMID:15885361 NCBI chr13:74,035,258...74,077,759
Ensembl chr13:74,035,080...74,077,783
JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 affects expression ISO Ursodeoxycholic Acid affects the expression of SPRY4 mRNA CTD PMID:18422935 NCBI chr18:32,593,370...32,609,890
Ensembl chr18:32,594,958...32,609,864
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SPTBN1 mRNA CTD PMID:15885361 NCBI chr14:114,517,839...114,700,199
Ensembl chr14:114,518,816...114,692,764
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 affects expression ISO Ursodeoxycholic Acid affects the expression of SSBP1 mRNA CTD PMID:18422935 NCBI chr 4:68,634,844...68,645,112
Ensembl chr 4:68,634,929...68,645,172
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [Amantadine co-treated with Ursodeoxycholic Acid co-treated with 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester] results in increased activity of STAT1 CTD PMID:15918519 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stk3 serine/threonine kinase 3 affects expression ISO Ursodeoxycholic Acid affects the expression of STK3 mRNA CTD PMID:18422935 NCBI chr 7:73,617,926...73,883,896
Ensembl chr 7:73,618,644...73,883,812
JBrowse link
G Stmn1 stathmin 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of STMN1 mRNA CTD PMID:15885361 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SULT1A1 mRNA CTD PMID:15885361 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of SULT1B1 mRNA CTD PMID:15885361 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases sulfation
multiple interactions
affects expression
ISO
EXP
SULT2A1 protein results in increased sulfation of Ursodeoxycholic Acid
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SULT2A1 protein]
Ursodeoxycholic Acid affects the expression of SULT2A1 protein
CTD PMID:16472600, PMID:20102295, PMID:32198087 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tagln transgelin decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TAGLN mRNA CTD PMID:15885361 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tat tyrosine aminotransferase multiple interactions EXP Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Sphingosine inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]]; Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]; Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased expression of TAT mRNA] CTD PMID:9398635 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tbxa2r thromboxane A2 receptor decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TBXA2R protein CTD PMID:18479249 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977
JBrowse link
G Tbxas1 thromboxane A synthase 1 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TBXAS1 protein CTD PMID:18479249 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP [Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C1 protein; [Ursodeoxycholic Acid co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of BCL2 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of MDM2 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of E2F1 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of TGFB1 mRNA]
Ursodeoxycholic Acid results in decreased expression of TGFB1 mRNA; Ursodeoxycholic Acid results in decreased expression of TGFB1 protein
CTD PMID:10510466, PMID:14514686, PMID:15222754, PMID:18479249, PMID:19493473, PMID:21274875 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TGFBI mRNA CTD PMID:15885361 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tgm2 transglutaminase 2 decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TGM2 mRNA CTD PMID:15885361 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Ursodeoxycholic Acid results in decreased expression of THRSP mRNA CTD PMID:15885361 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Tmem176b transmembrane protein 176B decreases expression EXP Ursodeoxycholic Acid results in decreased expression of TMEM176B mRNA CTD PMID:15885361 NCBI chr 4:78,450,724...78,458,600
Ensembl chr 4:78,450,724...78,458,179
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
ISO
EXP
Ursodeoxycholic Acid analog inhibits the reaction [[TNF protein co-treated with Cycloheximide] results in increased secretion of CXCL8 protein]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL2 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL5 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CXCL8 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of IL6 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of NFKB1 mRNA]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased secretion of IL6 protein]]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Ursodeoxycholic Acid analog inhibits the reaction [TNF protein results in increased activity of CASP7 protein]; Ursodeoxycholic Acid analog promotes the reaction [[TNF protein co-treated with Cycloheximide] results in increased expression of TNFAIP3 mRNA]
Ursodeoxycholic Acid results in decreased secretion of TNF protein
Ursodeoxycholic Acid results in decreased expression of TNF mRNA; Ursodeoxycholic Acid results in decreased expression of TNF protein
Ursodeoxycholic Acid affects the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [Rotenone results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [Tretinoin results in decreased expression of TNF mRNA]
Ursodeoxycholic Acid inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF mRNA]
CTD PMID:17438113, PMID:17888421, PMID:18590720, PMID:21146893, PMID:21274875, PMID:25502462, PMID:32198087 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO Ursodeoxycholic Acid analog promotes the reaction [[TNF protein co-treated with Cycloheximide] results in increased expression of TNFAIP3 mRNA] CTD PMID:21146893 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization
affects response to substance
increases ubiquitination
ISO
EXP
MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid results in increased ubiquitination of TP53 protein]; TP53 mutant form inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP3 protein]; TP53 mutant form inhibits the reaction [[Oxaliplatin co-treated with Ursodeoxycholic Acid] results in increased activity of CASP8 protein]
Ursodeoxycholic Acid inhibits the reaction [Cisplatin results in increased expression of TRP53 protein]
Ursodeoxycholic Acid affects the localization of TP53 protein
TP53 protein affects the susceptibility to Ursodeoxycholic Acid
[Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]] which results in increased degradation of TP53 protein; MDM2 mutant form inhibits the reaction [Ursodeoxycholic Acid affects the localization of TP53 protein]; NR3C1 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; NR3C2 mutant form inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]]; Ursodeoxycholic Acid affects the localization of and results in decreased phosphorylation of TP53 protein; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of TP53 mRNA]; Ursodeoxycholic Acid inhibits the reaction [E2F1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [TGFB1 protein results in increased expression of TP53 protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of and results in increased localization of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]; Ursodeoxycholic Acid inhibits the reaction [TP53 protein results in increased expression of BAX protein]; Ursodeoxycholic Acid promotes the reaction [TP53 protein binds to MDM2 protein]; Ursodeoxycholic Acid results in increased ubiquitination of and results in increased degradation of TP53 protein
CTD PMID:14514686, PMID:15222754, PMID:17431217, PMID:17881359, PMID:18558085, PMID:19728331, PMID:20137712, PMID:20807506 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression EXP Ursodeoxycholic Acid results in increased expression of TRIB3 mRNA CTD PMID:15885361 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Ubd ubiquitin D decreases expression EXP Ursodeoxycholic Acid results in decreased expression of UBD mRNA CTD PMID:15885361 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions
ISO
EXP
Ursodeoxycholic Acid results in increased expression of UGT1A1 mRNA
Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 mRNA]; Ursodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of UGT1A1 protein]
CTD PMID:18687751, PMID:32198087 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation
multiple interactions
ISO UGT1A3 protein results in increased glucuronidation of Ursodeoxycholic Acid
[Lapatinib results in decreased activity of UGT1A3 protein] which results in decreased glucuronidation of Ursodeoxycholic Acid
CTD PMID:31299240 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 multiple interactions
increases glucuronidation
EXP
ISO
Ursodeoxycholic Acid promotes the reaction [Ethinyl Estradiol results in decreased activity of UGT2B1 protein]; Ursodeoxycholic Acid promotes the reaction [Ethinyl Estradiol results in decreased expression of UGT2B1 protein]
UGT2B17 protein results in increased glucuronidation of Ursodeoxycholic Acid
CTD PMID:12663690, PMID:31299240 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Ursodeoxycholic Acid CTD PMID:31299240 NCBI chr14:22,597,103...22,619,968 JBrowse link
G Wdr33 WD repeat domain 33 affects expression ISO Ursodeoxycholic Acid affects the expression of WDR33 mRNA CTD PMID:18422935 NCBI chr18:24,584,832...24,689,681
Ensembl chr18:24,584,900...24,689,636
JBrowse link
G Wif1 Wnt inhibitory factor 1 increases expression EXP Ursodeoxycholic Acid results in increased expression of WIF1 mRNA CTD PMID:15885361 NCBI chr 7:63,094,955...63,165,158
Ensembl chr 7:63,094,911...63,165,159
JBrowse link
glycoursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Edn1 endothelin 1 decreases expression ISO glycoursodeoxycholic acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO [glycoursodeoxycholic acid co-treated with Dexamethasone] results in increased expression of SLC4A2 mRNA alternative form CTD PMID:18188457 NCBI chr 4:7,264,677...7,282,355
Ensembl chr 4:7,264,683...7,281,223
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP glycoursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA] CTD PMID:17881359 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
tauroursodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression EXP tauroursodeoxycholic acid results in decreased expression of A2M mRNA CTD PMID:15885361 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Aadat aminoadipate aminotransferase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of AADAT mRNA CTD PMID:15885361 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Aatf apoptosis antagonizing transcription factor increases expression EXP tauroursodeoxycholic acid results in increased expression of AATF mRNA CTD PMID:15885361 NCBI chr10:71,744,648...71,837,851
Ensembl chr10:71,744,659...71,837,851
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
increases expression
EXP tauroursodeoxycholic acid results in decreased expression of ABCB11 mRNA
tauroursodeoxycholic acid results in increased expression of and results in increased activity of ABCB11 protein
tauroursodeoxycholic acid results in increased expression of ABCB11 protein
CTD PMID:11672435, PMID:12644037, PMID:15885361 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
EXP tauroursodeoxycholic acid results in increased expression of and results in increased activity of ABCC2 protein
tauroursodeoxycholic acid results in increased expression of ABCC2 protein
CTD PMID:11672435, PMID:12644037 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP tauroursodeoxycholic acid results in increased expression of ABCC3 protein CTD PMID:11672435 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Acly ATP citrate lyase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of ACLY mRNA CTD PMID:15885361 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of ACSL1 mRNA CTD PMID:15885361 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of ACTN1 mRNA CTD PMID:15885361 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression EXP tauroursodeoxycholic acid results in decreased expression of ADH1 mRNA CTD PMID:15885361 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adk adenosine kinase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of ADK mRNA CTD PMID:15885361 NCBI chr15:3,033,535...3,435,888
Ensembl chr15:3,033,495...3,435,888
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
EXP tauroursodeoxycholic acid results in decreased expression of AGT mRNA
tauroursodeoxycholic acid inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased expression of FN1 protein]; tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein]
CTD PMID:15885361, PMID:25398788 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor increases abundance
increases secretion
ISO AHR gene mutant form results in increased abundance of tauroursodeoxycholic acid
AHR gene mutant form results in increased secretion of tauroursodeoxycholic acid
CTD PMID:32679164 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 increases expression EXP tauroursodeoxycholic acid results in increased expression of AKR1B8 mRNA CTD PMID:15885361 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of AKR1D1 mRNA CTD PMID:15885361 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:12721362, PMID:25398788 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Amy2a3 amylase 2a3 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of AMY1A mRNA CTD PMID:15885361 NCBI chr 2:216,373,674...216,382,260
Ensembl chr 2:216,339,154...216,382,260
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression
decreases expression
EXP tauroursodeoxycholic acid affects the expression of APAF1 mRNA; tauroursodeoxycholic acid affects the expression of APAF1 protein
tauroursodeoxycholic acid results in decreased expression of APAF1 mRNA
CTD PMID:15885361 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of APOA1 mRNA CTD PMID:15885361 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO
EXP
tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP2 protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP6 protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of BAX protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of TRP53 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in decreased expression of BCL2 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased activity of CASP2 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased activity of CASP6 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased expression of BAX protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased expression of TRP53 protein]
tauroursodeoxycholic acid affects the reaction [APP protein modified form affects the localization of NR3C2 protein]; tauroursodeoxycholic acid inhibits the reaction [[APP protein modified form results in increased activity of CASP3 protein] which results in increased cleavage of MAPT protein]; tauroursodeoxycholic acid inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]
CTD PMID:16728529, PMID:16923170, PMID:18368144 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aqp8 aquaporin 8 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of AQP8 mRNA CTD PMID:15885361 NCBI chr 1:193,424,818...193,430,665
Ensembl chr 1:193,424,812...193,430,676
JBrowse link
G Arg1 arginase 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of ARG1 mRNA CTD PMID:15885361 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 increases expression EXP tauroursodeoxycholic acid results in increased expression of ARL1 mRNA CTD PMID:15885361 NCBI chr 7:29,282,411...29,293,455
Ensembl chr 7:29,282,305...29,293,399
JBrowse link
G As3mt arsenite methyltransferase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of AS3MT mRNA CTD PMID:15885361 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
JBrowse link
G Atf4 activating transcription factor 4 decreases expression
multiple interactions
ISO tauroursodeoxycholic acid results in decreased expression of ATF4 mRNA
tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF4 mRNA]
tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of ATF4 protein]
CTD PMID:24312631, PMID:25611565, PMID:28223344 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO
EXP
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of ATF6 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased activity of ATF6 protein]
tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ATF6 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ATF6 mRNA]
CTD PMID:20165829, PMID:25611565, PMID:28223344 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases phosphorylation
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in decreased activity of BAD protein]; tauroursodeoxycholic acid results in increased phosphorylation of and results in decreased activity of BAD protein
tauroursodeoxycholic acid results in increased phosphorylation of and affects the localization of BAD protein; wortmannin inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and affects the localization of BAD protein]
tauroursodeoxycholic acid results in increased phosphorylation of BAD protein
CTD PMID:12721362, PMID:15190125, PMID:17559149 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression
ISO
EXP
tauroursodeoxycholic acid affects the localization of and results in decreased susceptibility to BAX protein; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of BAX protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased expression of BAX protein]
tauroursodeoxycholic acid results in decreased expression of BAX protein
tauroursodeoxycholic acid inhibits the reaction [3-nitropropionic acid affects the localization of BAX protein]; tauroursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]
tauroursodeoxycholic acid results in increased expression of BAX protein
CTD PMID:11080188, PMID:12627974, PMID:12721362, PMID:15255934, PMID:16923170, PMID:17881359 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP
ISO
tauroursodeoxycholic acid results in increased expression of BCL2 mRNA; tauroursodeoxycholic acid results in increased expression of BCL2 protein
tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in decreased expression of BCL2 protein]; tauroursodeoxycholic acid inhibits the reaction [Quercetin results in decreased expression of BCL2 protein]
CTD PMID:12721362, PMID:15255934, PMID:16923170, PMID:25611565, PMID:29751043 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of BCL2L1 mRNA CTD PMID:12721362 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP tauroursodeoxycholic acid results in decreased expression of C4B mRNA CTD PMID:15885361 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Canx calnexin multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Tunicamycin results in increased expression of CANX protein] CTD PMID:27588471 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Casp12 caspase 12 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased cleavage of CASP12 protein] CTD PMID:12198651 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp2 caspase 2 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP2 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased activity of CASP2 protein] CTD PMID:16923170 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
EXP
ISO
tauroursodeoxycholic acid inhibits the reaction [[APP protein modified form results in increased activity of CASP3 protein] which results in increased cleavage of MAPT protein]; tauroursodeoxycholic acid inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; tauroursodeoxycholic acid inhibits the reaction [Neurotoxins results in increased activity of CASP3 protein]; tauroursodeoxycholic acid inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of CASP3 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]
tauroursodeoxycholic acid inhibits the reaction [Quercetin promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; tauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]; tauroursodeoxycholic acid inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP3 protein]; tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]
tauroursodeoxycholic acid results in decreased activity of CASP3 protein
CTD PMID:12198651, PMID:12773247, PMID:15190125, PMID:15222754, PMID:17436368, PMID:17559149, PMID:18368144, PMID:25611565, PMID:29751043 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP4 protein] CTD PMID:17559149 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp6 caspase 6 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP6 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased activity of CASP6 protein] CTD PMID:16923170 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased activity of CASP7 protein]; tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased activity of CASP7 protein] CTD PMID:12198651, PMID:17559149 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Chenodeoxycholic Acid co-treated with tauroursodeoxycholic acid] results in increased activity of CASP9 protein; tauroursodeoxycholic acid inhibits the reaction [Quercetin promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]]; tauroursodeoxycholic acid inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP9 protein] CTD PMID:12773247, PMID:14976352, PMID:25611565 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CCN2 mRNA CTD PMID:15885361 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP tauroursodeoxycholic acid inhibits the reaction [Deoxycholic Acid results in increased expression of CCND1 protein]
tauroursodeoxycholic acid results in decreased expression of CCND1 mRNA; tauroursodeoxycholic acid results in decreased expression of CCND1 protein
CTD PMID:15885361, PMID:17431217 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh17 cadherin 17 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CDH17 mRNA CTD PMID:15885361 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CDH2 mRNA CTD PMID:15885361 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP tauroursodeoxycholic acid results in increased expression of CEBPD mRNA CTD PMID:15885361 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Xylitol results in increased expression of CHAC1 protein] CTD PMID:32275922 NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CITED2 mRNA CTD PMID:15885361 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CPS1 mRNA CTD PMID:15885361 NCBI chr 9:74,113,437...74,236,274
Ensembl chr 9:74,124,016...74,236,274
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]; calphostin C inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]; KN 62 inhibits the reaction [tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein]; tauroursodeoxycholic acid results in increased phosphorylation of and results in increased activity of CREB1 protein CTD PMID:15861431 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cs citrate synthase multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in decreased activity of CS protein]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in decreased expression of CS mRNA] CTD PMID:28223344 NCBI chr 7:2,752,680...2,778,963
Ensembl chr 7:2,752,680...2,778,963
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CSAD mRNA CTD PMID:15885361 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CTH mRNA CTD PMID:15885361 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CYP1A2 mRNA CTD PMID:15885361 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CYP27A1 mRNA CTD PMID:15885361 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CYP2A2 mRNA CTD PMID:15885361 NCBI chr 1:83,744,229...83,766,490
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CYP2B3 mRNA CTD PMID:15885361 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CYP2C12 mRNA CTD PMID:15885361 NCBI chr 1:258,709,726...258,766,873
Ensembl chr 1:258,709,721...258,766,881
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CYP2F4 mRNA CTD PMID:15885361 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of CYP4F1 mRNA CTD PMID:15885361 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP
ISO
tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of DDIT3 protein]
tauroursodeoxycholic acid inhibits the reaction [2,4-dichlorophenol results in increased expression of DDIT3 mRNA]; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of DDIT3 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of DDIT3 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of DDIT3 protein]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of DDIT3 mRNA]
tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of DDIT3 protein]; tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]
CTD PMID:23544086, PMID:24802810, PMID:25611565, PMID:27853103, PMID:28223344, PMID:29751043 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of DPP4 mRNA CTD PMID:15885361 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G E2f1 E2F transcription factor 1 increases expression
decreases expression
EXP tauroursodeoxycholic acid results in increased expression of E2F1 mRNA
tauroursodeoxycholic acid results in decreased expression of E2F1 protein
CTD PMID:15255934 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Edn1 endothelin 1 decreases expression ISO tauroursodeoxycholic acid results in decreased expression of EDN1 protein CTD PMID:15556138 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:26803847 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased phosphorylation of EIF2S1 protein]; tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein] CTD PMID:24802810, PMID:25611565 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of ENPP1 mRNA CTD PMID:15885361 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Ergic3 ERGIC and golgi 3 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Tunicamycin results in decreased expression of ERGIC3 protein] CTD PMID:27588471 NCBI chr 3:151,553,567...151,563,318
Ensembl chr 3:151,553,578...151,563,364
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] CTD PMID:29031535 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Dronabinol results in increased expression of ESRRG mRNA] CTD PMID:31054322 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO tauroursodeoxycholic acid results in decreased expression of FABP4 mRNA CTD PMID:24312631 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of FADS1 mRNA CTD PMID:15885361 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fads3 fatty acid desaturase 3 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of FADS3 mRNA CTD PMID:15885361 NCBI chr 1:226,091,774...226,108,332
Ensembl chr 1:226,091,774...226,108,332
JBrowse link
G Fah fumarylacetoacetate hydrolase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of FAH mRNA CTD PMID:15885361 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP tauroursodeoxycholic acid results in decreased expression of FAS mRNA CTD PMID:14623915 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Dronabinol results in increased expression of FLT1 mRNA] CTD PMID:31054322 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of FMO3 mRNA CTD PMID:15885361 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
EXP tauroursodeoxycholic acid results in decreased expression of FN1 mRNA
tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased expression of FN1 protein]
CTD PMID:15885361, PMID:25398788 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Taurolithocholic Acid results in increased expression of FOS mRNA] CTD PMID:18164257 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol results in decreased acetylation of FOXO1 protein] CTD PMID:23544086 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of FTCD mRNA CTD PMID:15885361 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of G6PC mRNA]; tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of G6PC protein] CTD PMID:23544086 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gamt guanidinoacetate N-methyltransferase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of GAMT mRNA CTD PMID:15885361 NCBI chr 7:12,314,848...12,317,998
Ensembl chr 7:12,314,848...12,317,998
JBrowse link
G Gckr glucokinase regulator decreases expression EXP tauroursodeoxycholic acid results in decreased expression of GCKR mRNA CTD PMID:15885361 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of GLUD1 mRNA CTD PMID:15885361 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Gpbar1 G protein-coupled bile acid receptor 1 decreases expression ISO tauroursodeoxycholic acid results in decreased expression of GPBAR1 mRNA CTD PMID:24312631 NCBI chr 9:81,555,914...81,560,931
Ensembl chr 9:81,559,605...81,560,594
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of GSTA5 mRNA CTD PMID:15885361 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of GSTM3 mRNA CTD PMID:15885361 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP tauroursodeoxycholic acid results in increased expression of GSTP1 mRNA CTD PMID:15885361 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of HAAO mRNA CTD PMID:15885361 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of HADH mRNA CTD PMID:15885361 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hbp1 HMG-box transcription factor 1 increases expression EXP tauroursodeoxycholic acid results in increased expression of HBP1 mRNA CTD PMID:15885361 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]] CTD PMID:23544086 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac4 histone deacetylase 4 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]; tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC4 protein] CTD PMID:23544086 NCBI chr 9:99,052,945...99,299,715
Ensembl chr 9:99,057,089...99,299,715
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]; tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC5 protein] CTD PMID:23544086 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hdac7 histone deacetylase 7 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol promotes the reaction [HDAC3 protein binds to HDAC4 protein binds to HDAC5 protein binds to HDAC7 protein]]; tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of HDAC7 protein] CTD PMID:23544086 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of HDHD2 mRNA CTD PMID:15885361 NCBI chr18:73,226,630...73,278,062
Ensembl chr18:73,226,630...73,278,337
JBrowse link
G Hpn hepsin decreases expression EXP tauroursodeoxycholic acid results in decreased expression of HPN mRNA CTD PMID:15885361 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hrg histidine-rich glycoprotein decreases expression EXP tauroursodeoxycholic acid results in decreased expression of HRG mRNA CTD PMID:15885361 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression
multiple interactions
decreases abundance
EXP
ISO
tauroursodeoxycholic acid results in decreased expression of HSD11B1 mRNA
tauroursodeoxycholic acid inhibits the reaction [Nicotine results in increased expression of HSD11B1 mRNA]
HSD11B1 gene mutant form results in decreased abundance of tauroursodeoxycholic acid
CTD PMID:15885361, PMID:25061560, PMID:26803847 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of HSD17B6 mRNA CTD PMID:15885361 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP
ISO
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]
tauroursodeoxycholic acid inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 mRNA]; tauroursodeoxycholic acid inhibits the reaction [2,4-dichlorophenol results in increased expression of HSPA5 protein]; tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of HSPA5 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of HSPA5 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of HSPA5 protein]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of HSPA5 mRNA]
tauroursodeoxycholic acid results in increased expression of HSPA5 protein
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of HSPA5 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased expression of HSPA5 protein]; tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]; tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in increased expression of HSPA5 protein]; tauroursodeoxycholic acid inhibits the reaction [Xylitol results in increased expression of HSPA5 protein]
CTD PMID:12198651, PMID:20165829, PMID:24802810, PMID:25160872, PMID:25611565, PMID:27853103, PMID:28223344, PMID:29751043, PMID:32275922 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of IGF1 mRNA CTD PMID:15885361 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP tauroursodeoxycholic acid results in increased expression of IGFBP1 mRNA CTD PMID:15885361 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il10 interleukin 10 increases abundance ISO IL10 gene mutant form results in increased abundance of tauroursodeoxycholic acid CTD PMID:27580383 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein] CTD PMID:29031535 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein] CTD PMID:29031535 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]] CTD PMID:20165829 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR1 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR1 mRNA] CTD PMID:28223344 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of ITPR2 mRNA]; tauroursodeoxycholic acid inhibits the reaction [N-palmitoylsphingosine results in increased expression of ITPR2 mRNA] CTD PMID:28223344 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Taurolithocholic Acid results in increased expression of JUN mRNA] CTD PMID:18164257 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kng2 kininogen 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of KNG2 mRNA CTD PMID:15885361 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lgals5 galectin 5 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of LGALS5 mRNA CTD PMID:15885361 NCBI chr10:66,226,015...66,229,293
Ensembl chr10:66,225,995...66,229,311
JBrowse link
G Lgals9 galectin 9 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of LGALS9 mRNA CTD PMID:15885361 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Limk2 LIM domain kinase 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of LIMK2 mRNA CTD PMID:15885361 NCBI chr14:83,564,048...83,641,996
Ensembl chr14:83,573,928...83,641,892
JBrowse link
G Lmbrd1 LMBR1 domain containing 1 increases expression EXP tauroursodeoxycholic acid results in increased expression of LMBRD1 mRNA CTD PMID:15885361 NCBI chr 9:30,939,555...31,038,381
Ensembl chr 9:30,939,555...31,038,379
JBrowse link
G Lox lysyl oxidase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of LOX mRNA CTD PMID:15885361 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Maob monoamine oxidase B decreases expression EXP tauroursodeoxycholic acid results in decreased expression of MAOB mRNA CTD PMID:15885361 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [[APP protein modified form results in increased activity of CASP3 protein] which results in increased cleavage of MAPT protein] CTD PMID:18368144 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Masp2 mannan-binding lectin serine peptidase 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of MASP2 mRNA CTD PMID:15885361 NCBI chr 5:165,415,105...165,429,857
Ensembl chr 5:165,415,136...165,430,054
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP tauroursodeoxycholic acid results in increased expression of MDM2 mRNA CTD PMID:15885361 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mef2a myocyte enhancer factor 2a multiple interactions ISO
EXP
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA]; tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of MFN2 mRNA] CTD PMID:28223344 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [ursolic acid results in decreased phosphorylation of MTOR protein] CTD PMID:24802810 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mx1 myxovirus (influenza virus) resistance 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of MX2 mRNA CTD PMID:15885361 NCBI chr11:37,891,150...37,916,775
Ensembl chr11:37,891,156...37,914,983
JBrowse link
G Nfia nuclear factor I/A decreases expression EXP tauroursodeoxycholic acid results in decreased expression of NFIA mRNA CTD PMID:15885361 NCBI chr 5:116,421,895...116,750,381
Ensembl chr 5:116,420,690...116,751,416
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression EXP tauroursodeoxycholic acid results in increased expression of NFKBIA protein CTD PMID:12721362 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein] CTD PMID:29031535 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of NOS2 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Gentamicins results in increased expression of NOS2 protein] CTD PMID:29751043 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP tauroursodeoxycholic acid results in increased expression of NR1D2 mRNA CTD PMID:15885361 NCBI chr15:8,730,871...8,757,165
Ensembl chr15:8,730,871...8,757,165
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO
EXP
tauroursodeoxycholic acid inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 mRNA]; tauroursodeoxycholic acid inhibits the reaction [IFNA1 protein results in decreased expression of NR3C1 protein]
[tauroursodeoxycholic acid co-treated with TGFB1 protein] results in increased localization of NR3C1 protein
CTD PMID:15222754, PMID:15885359 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects binding
increases expression
increases localization
multiple interactions
EXP tauroursodeoxycholic acid binds to NR3C2 protein
tauroursodeoxycholic acid results in increased expression of NR3C2 mRNA
tauroursodeoxycholic acid results in increased localization of NR3C2 protein
[tauroursodeoxycholic acid binds to NR3C2 protein] which affects the localization of NR3C2 protein; [tauroursodeoxycholic acid co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; tauroursodeoxycholic acid affects the reaction [APP protein modified form affects the localization of NR3C2 protein]; tauroursodeoxycholic acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; tauroursodeoxycholic acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]
CTD PMID:15222754, PMID:16728529 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nup62 nucleoporin 62 increases expression EXP tauroursodeoxycholic acid results in increased expression of NUP62 mRNA CTD PMID:15885361 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Otc ornithine carbamoyltransferase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of OTC mRNA CTD PMID:15885361 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of PACS2 mRNA] CTD PMID:28223344 NCBI chr 6:137,824,136...137,889,144
Ensembl chr 6:137,824,213...137,887,418
JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of PAH mRNA CTD PMID:15885361 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Chenodeoxycholic Acid co-treated with tauroursodeoxycholic acid] results in increased cleavage of PARP1 protein; tauroursodeoxycholic acid inhibits the reaction [Quercetin promotes the reaction [Cisplatin results in increased cleavage of PARP1 protein]] CTD PMID:14976352, PMID:25611565 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pc pyruvate carboxylase multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased activity of PC protein] CTD PMID:28223344 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol results in decreased acetylation of PCK1 protein]; tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of PCK1 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of PCK1 protein] CTD PMID:23544086 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of PDLIM1 mRNA CTD PMID:15885361 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of PECR mRNA CTD PMID:15885361 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of PHYH mRNA CTD PMID:15885361 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Por cytochrome p450 oxidoreductase affects abundance ISO POR gene mutant form affects the abundance of tauroursodeoxycholic acid CTD PMID:25034404 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases abundance ISO PPARA gene mutant form results in decreased abundance of tauroursodeoxycholic acid CTD PMID:29175453 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A mRNA]; tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of PPARGC1A protein] CTD PMID:20165829 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP2 protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased activity of CASP6 protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of BAX protein]; tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of TRP53 protein] CTD PMID:16923170 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of RB1 protein CTD PMID:15255934 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rnf138 ring finger protein 138 increases expression EXP tauroursodeoxycholic acid results in increased expression of RNF138 mRNA CTD PMID:15885361 NCBI chr18:15,146,925...15,167,361 JBrowse link
G RT1-EC2 RT1 class Ib, locus EC2 increases expression EXP tauroursodeoxycholic acid results in increased expression of RT1-EC2 mRNA CTD PMID:15885361
G S100a6 S100 calcium binding protein A6 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of S100A6 mRNA CTD PMID:15885361 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Scarb2 scavenger receptor class B, member 2 increases expression EXP tauroursodeoxycholic acid results in increased expression of SCARB2 mRNA CTD PMID:15885361 NCBI chr14:17,064,173...17,115,620
Ensembl chr14:17,064,353...17,115,963
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SCD1 mRNA CTD PMID:15885361 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scp2 sterol carrier protein 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SCP2 mRNA CTD PMID:15885361 NCBI chr 5:127,647,934...127,735,703
Ensembl chr 5:127,620,274...127,735,739
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression EXP tauroursodeoxycholic acid results in increased expression of SERP1 mRNA CTD PMID:15885361 NCBI chr 2:148,718,279...148,722,263
Ensembl chr 2:148,718,280...148,722,263
JBrowse link
G Serpina1 serpin family A member 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased activity of CASP7 protein]; tauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]; tauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP4 protein] CTD PMID:17559149 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Serpind1 serpin family D member 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SERPIND1 mRNA CTD PMID:15885361 NCBI chr11:87,913,814...87,924,880
Ensembl chr11:87,913,806...87,924,816
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SH3BP5 mRNA CTD PMID:15885361 NCBI chr16:7,473,367...7,559,976
Ensembl chr16:7,473,370...7,538,201
JBrowse link
G Sirt2 sirtuin 2 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [Ethanol results in increased expression of SIRT2 protein] CTD PMID:23544086 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases expression EXP tauroursodeoxycholic acid results in increased expression of SLC10A2 protein CTD PMID:11672435 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SLC22A8 mRNA CTD PMID:15885361 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc26a1 solute carrier family 26 member 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SLC26A1 mRNA CTD PMID:15885361 NCBI chr14:2,050,805...2,056,091
Ensembl chr14:2,050,483...2,056,089
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SLC27A2 mRNA CTD PMID:15885361 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of SLC2A4 protein] CTD PMID:20165829 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SLC37A4 mRNA CTD PMID:15885361 NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024
JBrowse link
G Slc38a3 solute carrier family 38, member 3 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SLC38A3 mRNA CTD PMID:15885361 NCBI chr 8:116,406,258...116,423,752
Ensembl chr 8:116,406,241...116,422,366
JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression EXP tauroursodeoxycholic acid results in increased expression of SLC6A9 mRNA CTD PMID:15885361 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
G Smad3 SMAD family member 3 increases abundance ISO SMAD3 protein results in increased abundance of tauroursodeoxycholic acid CTD PMID:23034213 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snca synuclein alpha multiple interactions ISO 3-Hydroxybutyric Acid promotes the reaction [tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone]]; tauroursodeoxycholic acid inhibits the reaction [SNCA protein results in increased susceptibility to Rotenone] CTD PMID:16239214 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP tauroursodeoxycholic acid inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]] CTD PMID:25398788 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Quercetin results in decreased phosphorylation of STAT3 protein] CTD PMID:25611565 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stmn1 stathmin 1 increases expression EXP tauroursodeoxycholic acid results in increased expression of STMN1 mRNA CTD PMID:15885361 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SULT1A1 mRNA CTD PMID:15885361 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of SULT1B1 mRNA CTD PMID:15885361 NCBI chr14:22,142,412...22,155,246
Ensembl chr14:22,142,364...22,155,231
JBrowse link
G Tagln transgelin decreases expression EXP tauroursodeoxycholic acid results in decreased expression of TAGLN mRNA CTD PMID:15885361 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases expression EXP tauroursodeoxycholic acid results in decreased expression of TDO2 mRNA CTD PMID:15885361 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [tauroursodeoxycholic acid co-treated with TGFB1 protein] results in increased localization of NR3C1 protein; [tauroursodeoxycholic acid co-treated with TGFB1 protein] results in increased localization of NR3C2 protein; tauroursodeoxycholic acid inhibits the reaction [AGT protein promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; tauroursodeoxycholic acid inhibits the reaction [AGT protein results in increased secretion of TGFB1 protein]; tauroursodeoxycholic acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 mRNA]; tauroursodeoxycholic acid inhibits the reaction [TGFB1 protein results in decreased expression of NR3C2 protein]; tauroursodeoxycholic acid inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein] CTD PMID:15222754, PMID:25398788 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression EXP tauroursodeoxycholic acid results in decreased expression of TGFBI mRNA CTD PMID:15885361 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tgm2 transglutaminase 2 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of TGM2 mRNA CTD PMID:15885361 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP tauroursodeoxycholic acid results in decreased expression of THRSP mRNA CTD PMID:15885361 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link
G Tm4sf4 transmembrane 4 L six family member 4 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of TM4SF4 mRNA CTD PMID:15885361 NCBI chr 2:147,532,032...147,547,254
Ensembl chr 2:147,496,229...147,547,252
JBrowse link
G Tmem37 transmembrane protein 37 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of TMEM37 mRNA CTD PMID:15885361 NCBI chr13:36,094,665...36,101,443
Ensembl chr13:36,094,520...36,101,411
JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects response to substance
EXP
ISO
tauroursodeoxycholic acid inhibits the reaction [TP53 protein results in increased expression of BAX mRNA]; tauroursodeoxycholic acid results in increased expression of and results in increased stability of TP53 protein
tauroursodeoxycholic acid inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of TRP53 protein]; tauroursodeoxycholic acid inhibits the reaction [APP gene mutant form results in increased expression of TRP53 protein]
TP53 protein affects the susceptibility to tauroursodeoxycholic acid
CTD PMID:15255934, PMID:16923170, PMID:17431217, PMID:17881359 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B decreases expression EXP tauroursodeoxycholic acid results in decreased expression of UGT2B mRNA CTD PMID:15885361 Ensembl chr14:22,375,955...22,534,720 JBrowse link
G Upb1 beta-ureidopropionase 1 decreases expression EXP tauroursodeoxycholic acid results in decreased expression of UPB1 mRNA CTD PMID:15885361 NCBI chr20:14,167,383...14,193,724
Ensembl chr20:14,167,586...14,193,690
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [[N-palmitoylsphingosine co-treated with Dietary Fats] results in increased expression of VDAC1 mRNA] CTD PMID:28223344 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO tauroursodeoxycholic acid inhibits the reaction [Dronabinol results in increased expression of VEGFA mRNA] CTD PMID:31054322 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP
ISO
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]
tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in increased expression of XBP1 mRNA]; tauroursodeoxycholic acid inhibits the reaction [Quercetin results in increased splicing of XBP1 mRNA]
CTD PMID:20165829, PMID:25611565 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      molecular entity 19784
        polyatomic entity 19697
          heteroatomic molecular entity 19622
            hydroxides 19068
              organic hydroxy compound 18634
                hydroxy-5beta-cholanic acid 915
                  dihydroxy-5beta-cholanic acid 765
                    ursodeoxycholic acid 383
                      3alpha,7beta-dihydroxy-12-oxo-5beta-cholanic acid 0
                      glycoursodeoxycholic acid 4
                      tauroursodeoxycholic acid 184
                      ursodeoxycholoyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic polycyclic compound 16384
                                  steroid 12788
                                    steroid fundamental parent 12403
                                      cholane 916
                                        cholanoid 916
                                          cholanic acids 915
                                            cholanic acid 915
                                              5beta-cholanic acid 915
                                                hydroxy-5beta-cholanic acid 915
                                                  dihydroxy-5beta-cholanic acid 765
                                                    ursodeoxycholic acid 383
                                                      3alpha,7beta-dihydroxy-12-oxo-5beta-cholanic acid 0
                                                      glycoursodeoxycholic acid 4
                                                      tauroursodeoxycholic acid 184
                                                      ursodeoxycholoyl-CoA 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.