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ONTOLOGY REPORT - ANNOTATIONS


Term:idiopathic pulmonary fibrosis
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Accession:DOID:0050156 term browser browse the term
Definition:A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
Synonyms:exact_synonym: Cryptogenic Fibrosing Alveolitides;   Cryptogenic Fibrosing Alveolitis;   Familial Idiopathic Pulmonary Fibrosis;   Fibrocystic Pulmonary Dysplasia;   Fibrocystic Pulmonary Dysplasias;   IPF;   Idiopathic Fibrosing Alveolitis, Chronic Form;   Idiopathic Pulmonary Fibroses;   Usual Interstitial Pneumonia;   Usual Interstitial Pneumonias;   usual interstitial pneumonitides;   usual interstitial pneumonitis
 narrow_synonym: Hamman Rich disease;   Hamman-Rich diseases;   UIP Hamman Rich disease
 related_synonym: Idiopathic Pulmonary Fibrosis, Susceptibility To
 primary_id: MESH:D054990;   RDO:0004398
 alt_id: OMIM:178500
 xref: GARD:8609;   ICD9CM:516.31;   NCI:C35715;   NCI:C35716
For additional species annotation, visit the Alliance of Genome Resources.


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idiopathic pulmonary fibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca3 ATP binding cassette subfamily A member 3 JBrowse link 10 13,723,365 13,780,558 RGD:8554872
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:5508222
G Atp11a ATPase phospholipid transporting 11A JBrowse link 16 81,990,340 82,100,222 RGD:11554173
G Bmp1 bone morphogenetic protein 1 JBrowse link 15 52,166,401 52,210,786 RGD:8554872
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:9586353
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 10 69,476,866 69,478,416 RGD:11554173
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:11341695
G Ctc1 CST telomere replication complex component 1 JBrowse link 10 55,596,172 55,616,873 RGD:8554872
G Cxcl6 C-X-C motif chemokine ligand 6 JBrowse link 14 18,860,201 18,920,839 RGD:5135241
RGD:5135250
G Dpp9 dipeptidyl peptidase 9 JBrowse link 9 10,846,493 10,882,560 RGD:11554173
G Dsp desmoplakin JBrowse link 17 27,286,811 27,334,453 RGD:11554173
G Dtnbp1 dystrobrevin binding protein 1 JBrowse link 17 20,090,136 20,182,332 RGD:8554872
G Ehmt2 euchromatic histone lysine methyltransferase 2 JBrowse link 20 4,576,033 4,592,980 RGD:9589169
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:11554173
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:11060143
G Fam13a family with sequence similarity 13, member A JBrowse link 4 89,183,180 89,281,282 RGD:11554173
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11049166
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:11049166
G Fosl2 FOS like 2, AP-1 transcription factor subunit JBrowse link 6 25,598,936 25,616,995 RGD:13592920
G Gper1 G protein-coupled estrogen receptor 1 JBrowse link 12 17,309,122 17,315,267 RGD:11554173
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:11554173
G Hps4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 JBrowse link 12 50,285,239 50,315,893 RGD:8554872
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:5144236
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:8554872
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:5147438
G Lama3 laminin subunit alpha 3 JBrowse link 18 3,704,866 3,941,215 RGD:8554872
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:4890373
RGD:8554872
G Mmp19 matrix metallopeptidase 19 JBrowse link 7 3,216,392 3,224,202 RGD:8554872
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:8694097
RGD:11554173
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:7244290
G Muc5b mucin 5B, oligomeric mucus/gel-forming JBrowse link 1 214,778,459 214,811,237 RGD:7240710
RGD:8554872
RGD:11554173
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:5684550
G Parn poly(A)-specific ribonuclease JBrowse link 10 1,309,724 1,461,123 RGD:11554173
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:10413908
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:11554173
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:5135280
RGD:5135507
RGD:5135461
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:5147566
G Rtel1 regulator of telomere elongation helicase 1 JBrowse link 3 176,818,012 176,856,531 RGD:8554872
RGD:11554173
G Rtkn2 rhotekin 2 JBrowse link 20 21,919,486 22,004,279 RGD:8554872
G Sftpa1 surfactant protein A1 JBrowse link 16 18,716,019 18,719,404 RGD:8554872
G Sftpc surfactant protein C JBrowse link 15 52,211,538 52,214,480 RGD:11554173
RGD:8554872
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6892915
RGD:11554173
G Stn1 STN1 subunit of CST complex JBrowse link 1 267,281,786 267,315,714 RGD:11554173
G Terc telomerase RNA component JBrowse link 2 116,432,723 116,433,110 RGD:8554872
RGD:11554173
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:8554872
RGD:11554173
RGD:11038666
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:11060143
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:5685036
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:13592920
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15502
    Pathological Conditions, Signs and Symptoms 8034
      Pathologic Processes 5202
        Fibrosis 1373
          pulmonary fibrosis 201
            idiopathic pulmonary fibrosis 49
Path 2
Term Annotations click to browse term
  disease 15502
    disease of anatomical entity 14856
      respiratory system disease 2409
        lower respiratory tract disease 1444
          lung disease 1403
            pneumonia 199
              idiopathic interstitial pneumonia 56
                idiopathic pulmonary fibrosis 49
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.