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ONTOLOGY REPORT - ANNOTATIONS


Term:idiopathic pulmonary fibrosis
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Accession:DOID:0050156 term browser browse the term
Definition:A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
Synonyms:exact_synonym: Cryptogenic Fibrosing Alveolitides;   Cryptogenic Fibrosing Alveolitis;   Familial Idiopathic Pulmonary Fibrosis;   Fibrocystic Pulmonary Dysplasia;   Fibrocystic Pulmonary Dysplasias;   IPF;   Idiopathic Fibrosing Alveolitis, Chronic Form;   Idiopathic Pulmonary Fibroses;   Usual Interstitial Pneumonia;   Usual Interstitial Pneumonias;   usual interstitial pneumonitides;   usual interstitial pneumonitis
 narrow_synonym: Hamman Rich disease;   Hamman-Rich diseases;   UIP Hamman Rich disease
 related_synonym: Idiopathic Pulmonary Fibrosis, Susceptibility To
 primary_id: MESH:D054990;   RDO:0004398
 alt_id: OMIM:178500
 xref: GARD:8609;   ICD9CM:516.31;   NCI:C35715;   NCI:C35716
For additional species annotation, visit the Alliance of Genome Resources.


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idiopathic pulmonary fibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCA3 ATP binding cassette subfamily A member 3 JBrowse link 3 39,689,133 39,732,466 RGD:9068941
G APOA1 apolipoprotein A1 JBrowse link 9 44,216,481 44,218,360 RGD:9068941
G ATP11A ATPase phospholipid transporting 11A JBrowse link 11 78,292,734 78,402,108 RGD:9068941
G BMP1 bone morphogenetic protein 1 JBrowse link 14 6,443,773 6,489,066 RGD:9068941
G BRD4 bromodomain containing 4 JBrowse link 2 62,250,958 62,345,851 RGD:9068941
G CFLAR CASP8 and FADD like apoptosis regulator JBrowse link 15 104,780,744 104,835,631 RGD:9068941
G CTC1 CST telomere replication complex component 1 JBrowse link 12 53,427,807 53,454,149 RGD:9068941
G DPP9 dipeptidyl peptidase 9 JBrowse link 2 74,134,520 74,179,740 RGD:9068941
G DSP desmoplakin JBrowse link 7 4,862,649 4,915,626 RGD:9068941
G DTNBP1 dystrobrevin binding protein 1 JBrowse link 7 11,602,470 11,720,156 RGD:9068941
G EHMT2 euchromatic histone lysine methyltransferase 2 JBrowse link 7 23,977,683 23,992,673 RGD:9068941
G ESR1 estrogen receptor 1 JBrowse link 1 14,217,032 14,604,906 RGD:9068941
G F3 coagulation factor III, tissue factor JBrowse link 4 122,827,018 122,837,673 RGD:9068941
G FAM13A family with sequence similarity 13 member A JBrowse link 8 130,021,581 130,327,731 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 14 100,927,305 100,954,781 RGD:9068941
G FASLG Fas ligand (TNF superfamily, member 6) JBrowse link 9 115,068,314 115,075,147 RGD:9068941
G FOSL2 FOS like 2, AP-1 transcription factor subunit JBrowse link 3 110,820,403 110,842,903 RGD:9068941
G GPER1 G protein-coupled estrogen receptor 1 JBrowse link 3 711,427 715,982 RGD:9068941
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 1 190,625,436 190,673,926 RGD:9068941
G HPS4 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 JBrowse link 14 44,041,684 44,073,661 RGD:9068941
G IL1RL1 interleukin 1 receptor like 1 JBrowse link 3 51,868,549 51,902,454 RGD:9068941
G IL1RN interleukin 1 receptor antagonist RGD:9068941
G IL2RA interleukin 2 receptor subunit alpha JBrowse link 10 64,948,149 65,001,320 RGD:9068941
G LAMA3 laminin subunit alpha 3 JBrowse link 6 108,548,818 108,805,700 RGD:9068941
G MMP1 matrix metallopeptidase 1 JBrowse link 9 33,411,738 33,420,205 RGD:9068941
G MMP19 matrix metallopeptidase 19 JBrowse link 5 21,279,514 21,285,943 RGD:9068941
G MMP3 matrix metallopeptidase 3 JBrowse link 9 33,446,969 33,453,995 RGD:9068941
G MUC1 mucin 1, cell surface associated JBrowse link 4 94,626,317 94,631,194 RGD:9068941
G MUC5B mucin 5B, oligomeric mucus/gel-forming JBrowse link 2 807,685 842,096 RGD:7240710
RGD:9068941
G NTRK2 neurotrophic receptor tyrosine kinase 2 JBrowse link 10 30,030,050 30,429,938 RGD:9068941
G PARN poly(A)-specific ribonuclease JBrowse link 3 28,616,808 28,802,506 RGD:9068941
G PARP1 poly(ADP-ribose) polymerase 1 JBrowse link 10 14,203,157 14,241,164 RGD:9068941
G PLAU plasminogen activator, urokinase JBrowse link 14 76,629,313 76,635,173 RGD:9068941
G PTGS2 prostaglandin-endoperoxide synthase 2 JBrowse link 9 127,850,164 127,858,866 RGD:9068941
G RTEL1 regulator of telomere elongation helicase 1 JBrowse link 17 62,611,844 62,636,628 RGD:9068941
G RTKN2 rhotekin 2 JBrowse link 14 65,686,718 65,861,385 RGD:9068941
G SFTPA1 surfactant protein A1 JBrowse link 14 82,091,178 82,095,393 RGD:9068941
G SFTPC surfactant protein C JBrowse link 14 6,440,309 6,443,104 RGD:9068941
G STAT3 signal transducer and activator of transcription 3 JBrowse link 12 20,407,316 20,471,091 RGD:9068941
G STN1 STN1 subunit of CST complex JBrowse link 14 114,808,217 114,851,130 RGD:9068941
G TERT telomerase reverse transcriptase JBrowse link 16 79,258,591 79,276,421 RGD:9068941
G TFPI tissue factor pathway inhibitor JBrowse link 15 92,345,083 92,409,962 RGD:9068941
G THBD thrombomodulin JBrowse link 17 30,219,870 30,223,499 RGD:9068941
G TNF tumor necrosis factor JBrowse link 7 23,699,635 23,702,393 RGD:9068941
G WNT5A Wnt family member 5A JBrowse link 13 37,344,684 37,367,215 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12055
    Pathological Conditions, Signs and Symptoms 6917
      Pathologic Processes 4695
        Fibrosis 1266
          pulmonary fibrosis 195
            idiopathic pulmonary fibrosis 45
Path 2
Term Annotations click to browse term
  disease 12055
    disease of anatomical entity 11715
      respiratory system disease 2212
        lower respiratory tract disease 1371
          lung disease 1333
            pneumonia 190
              idiopathic interstitial pneumonia 52
                idiopathic pulmonary fibrosis 45
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.