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ONTOLOGY REPORT - ANNOTATIONS


Term:renal fibrosis
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Accession:DOID:0050855 term browser browse the term
Definition:A pathological condition where fibrous connective tissue invades the kidney, usually as a consequence of inflammation or other injury. It is characterized by glomerulosclerosis and tubulointerstitial fibrosis - the final common manifestation of a wide variety of chronic kidney diseases.
Synonyms:exact_synonym: kidney fibrosis
 primary_id: RDO:9000014
For additional species annotation, visit the Alliance of Genome Resources.


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renal fibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:8158033
RGD:12879403
G Adam17 ADAM metallopeptidase domain 17 JBrowse link 6 43,400,525 43,448,280 RGD:13703100
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:7243851
RGD:7245533
RGD:7244186
G Arrb2 arrestin, beta 2 JBrowse link 10 57,040,252 57,048,045 RGD:13506828
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:7241554
G Bmp6 bone morphogenetic protein 6 JBrowse link 17 26,955,142 27,112,820 RGD:7242415
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:7175323
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:9068421
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:7257551
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:7243118
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6907431
G Cybb cytochrome b-245 beta chain JBrowse link X 14,578,330 14,610,049 RGD:11040697
G Cygb cytoglobin JBrowse link 10 105,618,325 105,628,091 RGD:9685174
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:7243130
G Ece1 endothelin converting enzyme 1 JBrowse link 5 156,215,469 156,318,652 RGD:7244179
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:7244179
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:7248781
RGD:7248783
RGD:7248782
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:11041600
G Fcar Fc fragment of IgA receptor JBrowse link 1 73,230,392 73,263,462 RGD:7242172
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:9068421
G Gfer growth factor, augmenter of liver regeneration JBrowse link 10 14,059,347 14,061,703 RGD:13506791
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:7245951
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:10755746
RGD:10755751
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:11060152
G Lcn2 lipocalin 2 JBrowse link 3 11,414,189 11,417,534 RGD:7245951
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:7243102
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:7244171
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:7207134
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:13204847
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:7207450
G Ncf2 neutrophil cytosolic factor 2 JBrowse link 13 70,226,441 70,259,019 RGD:9587793
G Ncf2em1Mcwi neutrophil cytosolic factor 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:9587793
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:11035221
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:7241138
RGD:7241268
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:7242027
G Resp18 regulated endocrine-specific protein 18 JBrowse link 9 82,470,794 82,477,136 RGD:14348960
G Resp18em2Mcwi regulated endocrine-specific protein 18; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:14348960
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11073616
RGD:11073686
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:7175536
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:7244136
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:7207895
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7207895
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:7245536
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:7247643
focal segmental glomerulosclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin, alpha 2, smooth muscle, aorta JBrowse link 1 252,537,614 252,550,394 RGD:11554173
G Actn4 actinin alpha 4 JBrowse link 1 87,078,012 87,147,347 RGD:1598731
RGD:11554173
G Actr3 ARP3 actin related protein 3 homolog JBrowse link 13 41,695,520 41,738,622 RGD:2292230
RGD:11575049
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:5129175
RGD:11554173
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:5129175
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:5129175
G Angpt2 angiopoietin 2 JBrowse link 16 75,966,480 76,016,147 RGD:2314213
G Anln anillin, actin binding protein JBrowse link 8 23,336,455 23,397,122 RGD:11554173
G Bdkrb1 bradykinin receptor B1 JBrowse link 6 129,437,423 129,441,553 RGD:7175321
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:13782344
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:7205647
G Ccl11 C-C motif chemokine ligand 11 JBrowse link 10 69,434,965 69,439,566 RGD:7247740
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:7241818
G Ccn2 cellular communication network factor 2 JBrowse link 1 21,851,657 21,854,773 RGD:11554173
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:1600628
RGD:11554173
RGD:8554872
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:7242704
G Col4a1 collagen type IV alpha 1 chain JBrowse link 16 83,522,162 83,632,153 RGD:11554173
G Crb2 crumbs cell polarity complex component 2 JBrowse link 3 22,037,812 22,061,247 RGD:11554173
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:11554173
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:11554173
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:11554173
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:11554173
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:10402764
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7175321
G Inf2 inverted formin, FH2 and WH2 domain containing JBrowse link 6 137,162,593 137,180,198 RGD:11554173
RGD:8554872
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:6907385
G Lamb2 laminin subunit beta 2 JBrowse link 8 117,268,335 117,280,517 RGD:8554872
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:2308781
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:2308781
G Mir193a microRNA 193a JBrowse link 10 67,065,885 67,065,996 RGD:13592920
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:2325738
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:2325738
G Mpv17 mitochondrial inner membrane protein MPV17 JBrowse link 6 26,585,713 26,600,265 RGD:11554173
G Myh10 myosin heavy chain 10 JBrowse link 10 55,274,910 55,406,738 RGD:11554173
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:6903254
RGD:11554173
G Myo1e myosin IE JBrowse link 8 76,644,715 76,840,240 RGD:11554173
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:11554173
G Nphs1 NPHS1 nephrin JBrowse link 1 88,922,346 88,950,560 RGD:8554872
RGD:11554173
G Nphs2 NPHS2, podocin JBrowse link 13 73,929,136 73,941,522 RGD:11554173
G Nxf7 nuclear RNA export factor 7 JBrowse link X 106,049,075 106,066,334 RGD:8554872
G Pax2 paired box 2 JBrowse link 1 264,493,579 264,585,073 RGD:11554173
G Pcna proliferating cell nuclear antigen JBrowse link 3 124,880,698 124,884,570 RGD:11554173
G Pias1 protein inhibitor of activated STAT, 1 JBrowse link 8 67,771,720 67,869,015 RGD:8693412
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link 2 241,909,332 242,186,861 RGD:13515117
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link 15 4,209,702 4,236,895 RGD:13515117
G Rap1gap Rap1 GTPase-activating protein JBrowse link 5 156,008,868 156,074,350 RGD:9835343
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11554173
RGD:13208548
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:12859042
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:11554173
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11554173
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:7245511
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:7245511
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:7245511
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:7247440
RGD:11554173
RGD:8554872
RGD:7247581
RGD:7247580
RGD:7247445
RGD:7247444
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:2324671
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:7207031
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:11554173
focal segmental glomerulosclerosis 1 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:12880006
G Actn4 actinin alpha 4 JBrowse link 1 87,078,012 87,147,347 RGD:7240710
RGD:8554872
G Arhgap24 Rho GTPase activating protein 24 JBrowse link 14 8,383,211 8,600,526 RGD:8554872
focal segmental glomerulosclerosis 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:7240710
RGD:8554872
Focal Segmental Glomerulosclerosis 3 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:7240710
RGD:8554872
focal segmental glomerulosclerosis 5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Inf2 inverted formin, FH2 and WH2 domain containing JBrowse link 6 137,162,593 137,180,198 RGD:7240710
RGD:8554872
focal segmental glomerulosclerosis 6 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myo1e myosin IE JBrowse link 8 76,644,715 76,840,240 RGD:7240710
RGD:8554872
focal segmental glomerulosclerosis 7 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pax2 paired box 2 JBrowse link 1 264,493,579 264,585,073 RGD:8554872
RGD:7240710
focal segmental glomerulosclerosis 8 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anln anillin, actin binding protein JBrowse link 8 23,336,455 23,397,122 RGD:8554872
RGD:7240710
focal segmental glomerulosclerosis 9 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crb2 crumbs cell polarity complex component 2 JBrowse link 3 22,037,812 22,061,247 RGD:8554872
RGD:7240710
glomerulosclerosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:12879389
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:7243247
RGD:7244139
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:6903859
G Agtr2 angiotensin II receptor, type 2 JBrowse link X 119,389,480 119,393,845 RGD:6903284
RGD:6903882
RGD:6903859
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6903199
RGD:6903285
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:7257557
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:7364801
G Fbn1 fibrillin 1 JBrowse link 3 117,569,708 117,766,160 RGD:7365080
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7175503
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:7207203
RGD:7207363
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:7207203
RGD:8547929
G Pla2g7 phospholipase A2 group VII JBrowse link 9 19,935,754 19,978,013 RGD:7248790
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:11079199
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin RGD:11079199
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:8553043
G Rgs2 regulator of G-protein signaling 2 JBrowse link 13 60,846,458 60,849,061 RGD:13524570
G Rnls renalase, FAD-dependent amine oxidase JBrowse link 1 251,828,285 252,101,963 RGD:7327155
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:11073618
RGD:11073688
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:12879501
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6903837
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:7245475
nephrotic syndrome type 2 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa5 annexin A5 JBrowse link 2 123,162,477 123,194,730 RGD:7242031
G Axdnd1 axonemal dynein light chain domain containing 1 JBrowse link 13 73,950,422 74,025,237 RGD:8554872
G Nphs2 NPHS2, podocin JBrowse link 13 73,929,136 73,941,522 RGD:7240710
RGD:8554872
RGD:11554173
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:7174729
G Nup205 nucleoporin 205 JBrowse link 4 62,703,779 62,773,931 RGD:11554173
G Nup93 nucleoporin 93 JBrowse link 19 11,159,769 11,263,980 RGD:11554173
G Pla2g7 phospholipase A2 group VII JBrowse link 9 19,935,754 19,978,013 RGD:7248793
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:7257521
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 JBrowse link 8 6,811,543 6,917,534 RGD:7247446
G Xpo5 exportin 5 JBrowse link 9 17,125,201 17,163,170 RGD:11554173
Tubulointerstitial Fibrosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10401065
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:5134352
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:13446413
RGD:1304308
G Tgfbi transforming growth factor, beta induced JBrowse link 17 8,400,123 8,429,338 RGD:1304308

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14759
    Pathological Conditions, Signs and Symptoms 7254
      Pathologic Processes 4755
        Fibrosis 1322
          renal fibrosis 158
            Tubulointerstitial Fibrosis 5
            glomerulosclerosis + 119
Path 2
Term Annotations click to browse term
  disease 14759
    disease of anatomical entity 13978
      Urogenital Diseases 3755
        urinary system disease 1990
          kidney disease 1786
            renal fibrosis 158
              Tubulointerstitial Fibrosis 5
              glomerulosclerosis + 119
paths to the root