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ONTOLOGY REPORT - ANNOTATIONS


Term:dermatomyositis
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Accession:DOID:10223 term browser browse the term
Definition:A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Synonyms:exact_synonym: Dermatopolymyositides;   Dermatopolymyositis;   Polymyositis with skin involvement;   Polymyositis-Dermatomyositides;   dermatomyositides;   polymyositis dermatomyositis
 related_synonym: Amyopathic dermatomyositis
 primary_id: MESH:D003882
 alt_id: RDO:0004203
 xref: GARD:6263
For additional species annotation, visit the Alliance of Genome Resources.


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dermatomyositis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angptl2 angiopoietin-like 2 JBrowse link 3 12,262,822 12,292,665 RGD:13592920
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:11554173
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:11554173
G Ccr2 C-C motif chemokine receptor 2 RGD:8661727
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6893508
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:8547765
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:8547765
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:9491763
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:8662437
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:8548628
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:7794747
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:4889547
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:11554173
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11554173
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:7794747
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:8693750
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:8547876
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:8547876
G Pms1 PMS1 homolog 1, mismatch repair system component JBrowse link 9 53,120,656 53,206,520 RGD:2324870
G Stat4 signal transducer and activator of transcription 4 JBrowse link 9 54,340,649 54,457,753 RGD:8661693
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:5685006
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:7794747
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:7794747
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:7794747
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:11554173
Amyopathic Dermatomyositis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RT1-Ba RT1 class II, locus Ba JBrowse link 20 4,066,133 4,070,726 RGD:5147790
RGD:5147796
RGD:8547569
nodular nonsuppurative panniculitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Serpina1 serpin family A member 1 JBrowse link 6 127,610,241 127,632,265 RGD:11554173
otulipenia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Otulin OTU deubiquitinase with linear linkage specificity JBrowse link 2 80,267,724 80,293,204 RGD:8554872
RGD:7240710
RGD:11554173
Subcutaneous Panniculitis-like T-Cell Lymphoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Havcr2 hepatitis A virus cellular receptor 2 JBrowse link 10 31,561,838 31,590,624 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14759
    sensory system disease 4231
      skin disease 2240
        dermatomyositis 29
          Amyopathic Dermatomyositis 1
          C9 Deficiency with Dermatomyositis 0
          adult dermatomyositis 0
          childhood type dermatomyositis 0
          panniculitis + 3
Path 2
Term Annotations click to browse term
  disease 14759
    disease of anatomical entity 13978
      nervous system disease 9097
        peripheral nervous system disease 1998
          neuropathy 1823
            neuromuscular disease 1406
              muscular disease 902
                muscle tissue disease 631
                  myopathy 521
                    myositis 69
                      Polymyositis 34
                        dermatomyositis 29
                          Amyopathic Dermatomyositis 1
                          C9 Deficiency with Dermatomyositis 0
                          adult dermatomyositis 0
                          childhood type dermatomyositis 0
                          panniculitis + 3
paths to the root