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ONTOLOGY REPORT - ANNOTATIONS


Term:thrombotic thrombocytopenic purpura
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Accession:DOID:10772 term browser browse the term
Definition:An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.
Synonyms:exact_synonym: Familial Thrombotic Microangiopathy;   Familial Thrombotic Thrombocytopenia Purpura;   Familial Thrombotic Thrombocytopenic Purpura;   MICROANGIOPATHIC HEMOLYTIC ANEMIA;   Microangiopathic Hemolytic Anemia, Congenital;   Moschcowitz Disease;   Moschcowitz's syndrome;   Moschkowitz disease;   TTP;   USS;   Upshaw-Schulman syndrome;   congenital thrombotic thrombocytopenic purpura;   deficiency of Upshaw factor;   hereditary thrombotic thrombocytopenic purpura;   hereditary thrombotic thrombocytopenic purpura, infantile- or adult-onset;   thrombotic thrombopenic purpura
 narrow_synonym: Familial TTP/HUS;   Familial thrombotic thrombocytopenic purpura / haemolytic uraemic syndrome;   thrombotic thrombocytopenic purpura, adult onset;   thrombotic thrombocytopenic purpura, chronic relapsing
 primary_id: MESH:D011697
 alt_id: OMIM:274150
 xref: GARD:9430;   ICD10CM:M31.1;   NCI:C78797
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thrombotic thrombocytopenic purpura term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 JBrowse link NW_004955513 2,761,386 2,786,447 RGD:7240710
G Cd36 CD36 molecule JBrowse link NW_004955410 5,003,720 5,120,903 RGD:9068941
G F3 coagulation factor III, tissue factor JBrowse link NW_004955423 254,060 264,448 RGD:9068941
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link NW_004955459 3,097,229 3,105,566 RGD:9068941
G Tfpi tissue factor pathway inhibitor JBrowse link NW_004955403 10,925,155 11,004,229 RGD:9068941
G Thbd thrombomodulin JBrowse link NW_004955415 30,222,830 30,226,406 RGD:9068941
Thrombotic Thrombocytopenic Purpura, Acquired term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 JBrowse link NW_004955513 2,761,386 2,786,447 RGD:9068941
G Vwf von Willebrand factor JBrowse link NW_004955413 3,672,470 3,825,588 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11744
    disease of anatomical entity 11304
      immune system disease 2200
        Thrombocytopenic Purpura 32
          thrombotic thrombocytopenic purpura 7
            Thrombotic Thrombocytopenic Purpura, Acquired 2
Path 2
Term Annotations click to browse term
  disease 11744
    disease of anatomical entity 11304
      Hemic and Lymphatic Diseases 1692
        hematopoietic system disease 1360
          blood coagulation disease 518
            hemorrhagic disease 505
              blood platelet disease 223
                thrombocytopenia 178
                  Thrombotic Microangiopathies 53
                    Thrombocytopenic Purpura 32
                      thrombotic thrombocytopenic purpura 7
                        Thrombotic Thrombocytopenic Purpura, Acquired 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.