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ONTOLOGY REPORT - ANNOTATIONS


Term:thrombotic thrombocytopenic purpura
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Accession:DOID:10772 term browser browse the term
Definition:An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.
Synonyms:exact_synonym: Congenital Thrombotic Thrombocytopenic Purpura;   Familial Thrombotic Microangiopathy;   Familial Thrombotic Thrombocytopenia Purpura;   Familial Thrombotic Thrombocytopenic Purpura;   MICROANGIOPATHIC HEMOLYTIC ANEMIA;   Microangiopathic Hemolytic Anemia, Congenital;   Moschcowitz Disease;   Moschcowitz's syndrome;   Moschkowitz Disease;   TTP;   Thrombotic Thrombopenic Purpura;   USS;   deficiency of Upshaw factor
 narrow_synonym: Adult Onset Purpura, Thrombotic Thrombocytopenic;   Familial TTP/HUS;   Familial thrombotic thrombocytopenic purpura / haemolytic uraemic syndrome;   Upshaw-Schulman syndrome;   chronic relapsing thrombotic thrombocytopenic purpura
 primary_id: MESH:D011697;   RDO:0002621
 alt_id: OMIM:274150
 xref: GARD:9430;   NCI:C78797
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thrombotic thrombocytopenic purpura term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 JBrowse link 3 5,519,921 5,558,390 RGD:7240710
RGD:8554872
RGD:11554173
RGD:10449043
RGD:1598736
RGD:10449028
RGD:10449037
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:11041104
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:11554173
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:11100014
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:11041754
G Tfpi tissue factor pathway inhibitor JBrowse link 3 71,852,738 71,902,127 RGD:11340214
RGD:11554173
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:11554173
Thrombotic Thrombocytopenic Purpura, Acquired term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 JBrowse link 3 5,519,921 5,558,390 RGD:10449039
RGD:10449097
G Vwf von Willebrand factor JBrowse link 4 158,085,059 158,219,525 RGD:11079195

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      immune system disease 2517
        Thrombocytopenic Purpura 40
          thrombotic thrombocytopenic purpura 8
            Thrombotic Thrombocytopenic Purpura, Acquired 2
Path 2
Term Annotations click to browse term
  disease 15590
    disease of anatomical entity 14919
      Hemic and Lymphatic Diseases 1704
        hematopoietic system disease 1426
          blood coagulation disease 444
            hemorrhagic disease 430
              blood platelet disease 191
                thrombocytopenia 129
                  Thrombotic Microangiopathies 67
                    Thrombocytopenic Purpura 40
                      thrombotic thrombocytopenic purpura 8
                        Thrombotic Thrombocytopenic Purpura, Acquired 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.