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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:membranous glomerulonephritis
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Accession:DOID:10976 term browser browse the term
Definition:A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Synonyms:exact_synonym: CONGENITAL MEMBRANOUS NEPHROPATHY DUE TO FETOMATERNAL ANTI-NEUTRAL ENDOPEPTIDASE ALLOIMMUNIZATION;   Extramembranous Glomerulopathy;   Heymann Nephritis;   Idiopathic Membranous Glomerulonephritides;   Idiopathic Membranous Glomerulonephritis;   Idiopathic Membranous Nephropathy;   MBNP;   Membranous Glomerulonephritides;   Membranous Glomerulonephropathy;   Membranous Glomerulopathy;   membranous nephropathy
 related_synonym: membranous nephropathy, susceptibility to
 primary_id: MESH:D015433
 alt_id: OMIM:614692;   RDO:0006868
 xref: ICD10CM:N03.2;   NCI:C34645
For additional species annotation, visit the Alliance of Genome Resources.


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membranous glomerulonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IEP protein:increased expression:serum RGD PMID:9453001 RGD:10046046 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 IEP RGD PMID:12507911 RGD:1598547 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1342223, PMID:9794552, PMID:11938814, PMID:12776520, PMID:15385633, PMID:17622271 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoa1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7900854 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoe apolipoprotein E IEP protein:increased expression:serum (rat) RGD PMID:22785171 RGD:6903854 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G C3 complement C3 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:25954969, PMID:10729746 RGD:5129563 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C7 complement C7 IEP RGD PMID:6241952 RGD:1599528 NCBI chr 2:54,707,621...54,781,624
Ensembl chr 2:54,709,138...54,777,729
JBrowse link
G Cd40 CD40 molecule treatment IMP
ISO
RGD PMID:23223173, PMID:23223173 RGD:8547786, RGD:8547786 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd40lg CD40 ligand treatment ISO associated with Lupus Erythematosus, Systemic RGD PMID:17911451, PMID:7564113 RGD:7248430, RGD:7248720 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B treatment IEP RGD PMID:24583340 RGD:10045363 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cfb complement factor B susceptibility ISO RGD PMID:3272818 RGD:7242764 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Cfh complement factor H IEP mRNA, protein:increased expression:glomerulus RGD PMID:12911541 RGD:1599888 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Gaa glucosidase, alpha, acid ISO CTD Direct Evidence: marker/mechanism CTD PMID:15466083 NCBI chr10:108,395,873...108,412,999
Ensembl chr10:108,395,860...108,413,059
JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:20588061 RGD:7175342 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Lrp2 LDL receptor related protein 2 IEP mRNA:decreased expression:glomerulus RGD PMID:10919857 RGD:1641827 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 IEP
IDA
mRNA, protein:increased expression:glomerulus, epithelial cell RGD PMID:7778686, PMID:7723231 RGD:1641937, RGD:1641936 NCBI chr14:80,911,281...80,923,290
Ensembl chr14:80,911,270...80,924,831
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEP protein:increased activity,protein:renal glomerulus: RGD PMID:18178252 RGD:10412641 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mme membrane metallo-endopeptidase ISO antenatal membranous glomerulonephritis
ClinVar Annotator: match by term: Congenital membranous nephropathy due to fetomaternal anti-neutral endopeptidase alloimmunization
ClinVar PMID:15464186, PMID:24033266, PMID:25565308, PMID:30311386, PMID:15464186 RGD:1600817 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP RGD PMID:8613533 RGD:8547919 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin IEP RGD PMID:15882266 RGD:1598706 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin IDA RGD PMID:15882266 RGD:1598706 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IDA RGD PMID:28711658 RGD:13439719 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Plg plasminogen TAS RGD PMID:1645711 RGD:1299252 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Ptger3 prostaglandin E receptor 3 IEP mRNA:increased expression:renal cortex (rat) RGD PMID:14636300 RGD:10043359 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Ptpru protein tyrosine phosphatase, receptor type, U IEP mRNA, protein:decreased expression:glomerulus RGD PMID:17457373 RGD:1642654 NCBI chr 5:149,922,374...149,996,352
Ensembl chr 5:149,922,352...149,996,334
JBrowse link
G Rhoa ras homolog family member A IMP protein:increased activity:epithelial cell RGD PMID:17376765 RGD:1642963 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G RT1-Ba RT1 class II, locus Ba ISO DNA:SNP: :rs2187668 (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:11436868, PMID:21323541 RGD:5147785 NCBI chr20:4,066,133...4,070,726
Ensembl chr20:4,066,132...4,070,721
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11436868 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G Shh sonic hedgehog signaling molecule ISO RGD PMID:24744439 RGD:12859042 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP protein:increased expression:kidney RGD PMID:8943481 RGD:2300069 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA RGD PMID:8982653 RGD:1601473 NCBI chr 4:66,624,181...66,846,745
Ensembl chr 4:66,670,618...66,846,805
JBrowse link
G Tf transferrin ISO associated with Lupus Erythematosus, Systemic RGD PMID:22328173 RGD:7244198 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tslp thymic stromal lymphopoietin treatment ISO RGD PMID:11920357 RGD:38549592 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    disease of anatomical entity 15356
      immune system disease 2931
        autoimmune disease 1670
          membranous glomerulonephritis 33
Path 2
Term Annotations click to browse term
  disease 16108
    disease of anatomical entity 15356
      Urogenital Diseases 4145
        urinary system disease 2069
          kidney disease 1857
            Glomerular Diseases 380
              glomerulonephritis 373
                membranous glomerulonephritis 33
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.