ONTOLOGY REPORT - ANNOTATIONS


Term:Gilles de la Tourette syndrome
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Accession:DOID:11119 term browser browse the term
Definition:A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
Synonyms:exact_synonym: Combined Multiple Motor and Vocal Tic Disorder;   GTS;   Gilles De La Tourette's Syndrome;   Gilles de la Tourette's Disease;   Guinon's disease;   TS;   Tourette Disease;   Tourette Disorder;   Tourette syndrome;   Tourette's Disease;   Tourette's Disorder;   Tourette's Syndrome;   Tourettes Disease;   Tourettes Disorder;   Tourettes syndrome;   chronic motor and vocal tic disorder;   motor-verbal tic disorder;   psychogenic tics
 narrow_synonym: TOURETTE DISORDER CHRONIC MOTOR TICS
 primary_id: MESH:D005879;   RDO:0005663
 alt_id: OMIM:137580
 xref: GARD:7783
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Gilles de la Tourette syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Baiap2 BAI1-associated protein 2 JBrowse link 10 109,107,326 109,187,458 RGD:11576298
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:2311576
RGD:6907444
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:11554173
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:13209010
RGD:13210516
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 JBrowse link 8 63,599,907 63,637,327 RGD:9693691
G Hdc histidine decarboxylase JBrowse link 3 119,057,524 119,075,599 RGD:7240710
RGD:8554872
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:13592920
G Slc6a3 solute carrier family 6 member 3 JBrowse link 1 32,323,011 32,363,983 RGD:13592920
G Slitrk1 SLIT and NTRK-like family, member 1 JBrowse link 15 93,303,382 93,307,420 RGD:7240710
RGD:8554872
G Tdo2 tryptophan 2,3-dioxygenase JBrowse link 2 180,897,059 180,914,919 RGD:1358595

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14875
    syndrome 4220
      Gilles de la Tourette syndrome 10
        Chronic Motor Tics 0
        X-Linked Modifier for Neurofunctional Defects 0
Path 2
Term Annotations click to browse term
  disease 14875
    disease of anatomical entity 14051
      nervous system disease 9116
        central nervous system disease 6913
          brain disease 6418
            disease of mental health 4325
              developmental disorder of mental health 2595
                specific developmental disorder 1330
                  tic disorder 10
                    Gilles de la Tourette syndrome 10
                      Chronic Motor Tics 0
                      X-Linked Modifier for Neurofunctional Defects 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.