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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hantavirus hemorrhagic fever with renal syndrome
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Accession:DOID:11266 term browser browse the term
Definition:An acute febrile disease occurring predominately in Asia. It is characterized by fever, prostration, vomiting, hemorrhagic phenonema, shock, and renal failure. It is caused by any one of several closely related species of the genus Hantavirus. The most severe form is caused by HANTAAN VIRUS whose natural host is the rodent Apodemus agrarius. Milder forms are caused by SEOUL VIRUS and transmitted by the rodents Rattus rattus and R. norvegicus, and the PUUMALA VIRUS with transmission by Clethrionomys galreolus.
Synonyms:exact_synonym: HFRS;   Puumala virus nephropathy;   Russian hemorrhagic fever;   epidemic hemorrhagic fever;   epidemic hemorrhagic fevers;   hemorrhagic fever with renal syndrome;   hemorrhagic nephroso nephritis;   hemorrhagic nephroso-nephritides;   hemorrhagic nephrosonephritis
 primary_id: MESH:D006480
 xref: ICD10CM:A98.5;   ICD9CM:078.6;   NCI:C84753
For additional species annotation, visit the Alliance of Genome Resources.


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Hantavirus hemorrhagic fever with renal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin severity ISO RGD PMID:14555823 RGD:11035280 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoc3 apolipoprotein C3 disease_progression ISO RGD PMID:20797315 RGD:7207210 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
JBrowse link
G Ifng interferon gamma severity ISO protein:increased expression:serum RGD PMID:22613426 RGD:6893374 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO protein:increased expression:T cell RGD PMID:21436245 RGD:5147436 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Itgb3 integrin subunit beta 3 severity ISO protein:increased expression:platelet RGD PMID:18419255 RGD:6907404 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
Korean hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 IEP mRNA:increased expression:lung RGD PMID:17878294 RGD:2325989 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha treatment IMP RGD PMID:17878294 RGD:2325989 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16058
    syndrome 6996
      Hantavirus hemorrhagic fever with renal syndrome 6
        Balkan hemorrhagic fever 0
        Hantavirosis 0
        Korean hemorrhagic fever 2
        nephropathia epidemica 0
        polyomavirus-associated nephropathy 0
Path 2
Term Annotations click to browse term
  disease 16058
    disease by infectious agent 1759
      viral infectious disease 1457
        RNA Virus Infections 1290
          Bunyaviridae Infections 8
            Hantavirus Infections 7
              Hantavirus hemorrhagic fever with renal syndrome 6
                Balkan hemorrhagic fever 0
                Hantavirosis 0
                Korean hemorrhagic fever 2
                nephropathia epidemica 0
                polyomavirus-associated nephropathy 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.