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ONTOLOGY REPORT - ANNOTATIONS


Term:sciatic neuropathy
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Accession:DOID:11446 term browser browse the term
Definition:Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Synonyms:exact_synonym: Sciatic Nerve Disease;   Sciatic Nerve Diseases;   Sciatic Nerve Injuries;   Sciatic Nerve Injury;   Sciatic Nerve Neuralgia-Neuritides;   Sciatic Nerve Neuralgia-Neuritis;   Sciatic Nerve Palsies;   Sciatic Nerve Palsy;   Sciatic Neuritides;   Sciatic Neuritis;   Sciatic Neuropathies
 related_synonym: Sciatic Inflammatory Neuropathy
 primary_id: MESH:D020426
 alt_id: RDO:0006542
For additional species annotation, visit the Alliance of Genome Resources.


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sciatic neuropathy term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 JBrowse link 7 46,104,523 46,180,039 RGD:12791994
G Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 JBrowse link 6 142,587,862 142,702,767 RGD:12791994
G Adrb2 adrenergic receptor, beta 2 JBrowse link 18 62,177,713 62,179,981 RGD:8548489
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) JBrowse link 8 124,556,587 124,569,707 RGD:5129198
G Akap12 A kinase (PRKA) anchor protein (gravin) 12 JBrowse link 10 4,266,329 4,359,471 RGD:14348968
G Amigo3 adhesion molecule with Ig like domain 3 JBrowse link 9 108,053,159 108,055,701 RGD:14390159
G Apoa1 apolipoprotein A-I JBrowse link 9 46,228,630 46,230,469 RGD:7495790
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,699,188 RGD:7495790
G Bdkrb1 bradykinin receptor, beta 1 JBrowse link 12 105,604,091 105,605,428 RGD:5129227
G Bdkrb2 bradykinin receptor, beta 2 JBrowse link 12 105,563,172 105,595,244 RGD:5129227
G Bdnf brain derived neurotrophic factor JBrowse link 2 109,674,700 109,727,043 RGD:8657100
RGD:10059363
G C3 complement component 3 JBrowse link 17 57,203,967 57,228,136 RGD:5129535
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit JBrowse link 14 30,039,941 30,491,156 RGD:6906922
G Calca calcitonin/calcitonin-related polypeptide, alpha JBrowse link 7 114,625,903 114,636,460 RGD:11554173
G Capn1 calpain 1 JBrowse link 19 5,988,545 6,015,825 RGD:13792589
G Capn2 calpain 2 JBrowse link 1 182,467,259 182,517,483 RGD:13792589
G Casp12 caspase 12 JBrowse link 9 5,345,442 5,373,034 RGD:13782273
G Casp3 caspase 3 JBrowse link 8 46,617,291 46,639,698 RGD:13782273
G Casp7 caspase 7 JBrowse link 19 56,396,634 56,442,348 RGD:13782273
G Casp8 caspase 8 JBrowse link 1 58,795,228 58,847,503 RGD:13782273
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:9479064
G Cav1 caveolin 1, caveolae protein JBrowse link 6 17,306,335 17,341,328 RGD:6784526
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:2307005
RGD:8549487
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:4890004
G Ccr2 chemokine (C-C motif) receptor 2 JBrowse link 9 124,101,918 124,109,140 RGD:8661781
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:10045367
G Cnr2 cannabinoid receptor 2 (macrophage) JBrowse link 4 135,895,189 135,920,219 RGD:2316195
G Crcp calcitonin gene-related peptide-receptor component protein JBrowse link 5 130,029,306 130,060,787 RGD:727768
G Creb1 cAMP responsive element binding protein 1 JBrowse link 1 64,532,315 64,604,548 RGD:10059430
G Crh corticotropin releasing hormone JBrowse link 3 19,693,401 19,695,396 RGD:5490542
G Cx3cr1 chemokine (C-X3-C motif) receptor 1 JBrowse link 9 120,048,683 120,068,296 RGD:9354422
RGD:1358720
RGD:9491396
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 9 57,998,029 58,027,023 RGD:4889134
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 19 46,667,165 46,673,000 RGD:4889112
G Dbn1 drebrin 1 JBrowse link 13 55,473,428 55,488,110 RGD:10398813
G Dnmt3a DNA methyltransferase 3A JBrowse link 12 3,804,986 3,914,443 RGD:9589072
G Elavl4 ELAV like RNA binding protein 4 JBrowse link 4 110,203,737 110,351,911 RGD:1579851
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,659 34,327,775 RGD:13792563
G Fgfr1 fibroblast growth factor receptor 1 JBrowse link 8 25,513,623 25,575,718 RGD:10402092
G Fubp1 far upstream element (FUSE) binding protein 1 JBrowse link 3 152,210,427 152,236,830 RGD:13673880
G Gc vitamin D binding protein JBrowse link 5 89,417,511 89,457,898 RGD:2316214
G Gdnf glial cell line derived neurotrophic factor JBrowse link 15 7,810,048 7,837,580 RGD:6218977
G Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 JBrowse link 19 58,235,581 58,455,946 RGD:6218963
G Gfra3 glial cell line derived neurotrophic factor family receptor alpha 3 JBrowse link 18 34,689,898 34,720,387 RGD:6218977
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) JBrowse link 2 25,291,177 25,319,199 RGD:13792690
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) JBrowse link 6 135,729,795 136,173,822 RGD:13792690
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 16 38,089,001 38,246,080 RGD:13792740
G Hgf hepatocyte growth factor JBrowse link 5 16,553,495 16,619,439 RGD:8548631
G Hmgb1 high mobility group box 1 JBrowse link 5 149,046,702 149,053,057 RGD:10402062
G Hmox1 heme oxygenase 1 JBrowse link 8 75,093,618 75,100,593 RGD:10755722
G Hrh3 histamine receptor H3 JBrowse link 2 180,099,465 180,104,407 RGD:1626418
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 JBrowse link 3 98,842,355 98,859,794 RGD:632873
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,960 21,028,797 RGD:8547739
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:7364826
RGD:7364836
G Il1b interleukin 1 beta JBrowse link 2 129,363,842 129,371,170 RGD:7364836
G Il1rn interleukin 1 receptor antagonist JBrowse link 2 24,336,860 24,351,491 RGD:7175064
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:5128675
G Il6ra interleukin 6 receptor, alpha JBrowse link 3 89,869,324 89,913,196 RGD:5128675
G Jam3 junction adhesion molecule 3 JBrowse link 9 27,097,384 27,155,421 RGD:7488944
G Kars lysyl-tRNA synthetase JBrowse link 8 111,993,439 112,011,354 RGD:12910554
G Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 JBrowse link 3 107,438,298 107,458,925 RGD:10411908
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 JBrowse link 7 46,097,123 46,100,867 RGD:7297043
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 JBrowse link 6 142,564,837 142,571,647 RGD:12791994
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 38,401,357 38,456,463 RGD:13703060
G Lrp1 low density lipoprotein receptor-related protein 1 JBrowse link 10 127,538,157 127,621,148 RGD:13792690
RGD:13800561
G Mag myelin-associated glycoprotein JBrowse link 7 30,899,175 30,914,921 RGD:9685295
G Map2 microtubule-associated protein 2 JBrowse link 1 66,175,246 66,442,583 RGD:6483083
G Mc4r melanocortin 4 receptor JBrowse link 18 66,857,705 66,860,487 RGD:6484557
G Mir381 microRNA 381 JBrowse link 12 109,726,822 109,726,896 RGD:13838658
G Mir96 microRNA 96 JBrowse link 6 30,169,446 30,169,551 RGD:11553932
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,744 164,955,850 RGD:13207330
G Mpz myelin protein zero JBrowse link 1 171,150,713 171,161,130 RGD:9685778
G Mtor mechanistic target of rapamycin kinase JBrowse link 4 148,448,582 148,557,685 RGD:10041037
G Myh4 myosin, heavy polypeptide 4, skeletal muscle JBrowse link 11 67,237,812 67,260,447 RGD:9686059
G Nefh neurofilament, heavy polypeptide JBrowse link 11 4,938,754 4,948,064 RGD:9693730
RGD:9743941
G Nefl neurofilament, light polypeptide JBrowse link 14 68,083,884 68,087,745 RGD:9743941
RGD:9743948
G Nefm neurofilament, medium polypeptide JBrowse link 14 68,119,545 68,125,004 RGD:9743941
RGD:9743948
G Nf1 neurofibromin 1 JBrowse link 11 79,338,389 79,581,609 RGD:12790590
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:10413869
G Ngf nerve growth factor JBrowse link 3 102,469,919 102,521,013 RGD:7242913
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) JBrowse link 11 95,568,818 95,587,698 RGD:5144067
RGD:10414078
G Nlgn2 neuroligin 2 JBrowse link 11 69,823,123 69,838,061 RGD:9831149
G Nlgn3 neuroligin 3 JBrowse link X 101,299,179 101,321,350 RGD:9831149
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 JBrowse link 4 149,468,597 149,485,180 RGD:13781948
G Nos1ap nitric oxide synthase 1 (neuronal) adaptor protein JBrowse link 1 170,314,700 170,589,849 RGD:7327169
G Nrg1 neuregulin 1 JBrowse link 8 31,809,465 32,884,820 RGD:10449012
G Nts neurotensin JBrowse link 10 102,481,756 102,490,418 RGD:9743903
G Oprl1 opioid receptor-like 1 JBrowse link 2 181,714,984 181,720,985 RGD:9835022
G Pcna proliferating cell nuclear antigen JBrowse link 2 132,249,286 132,253,180 RGD:10448976
G Pcsk5 proprotein convertase subtilisin/kexin type 5 JBrowse link 19 17,432,314 17,837,632 RGD:11556234
G Pdgfra platelet derived growth factor receptor, alpha polypeptide JBrowse link 5 75,151,400 75,198,211 RGD:11080976
G Pdgfrb platelet derived growth factor receptor, beta polypeptide JBrowse link 18 61,045,150 61,085,067 RGD:11080976
G Plat plasminogen activator, tissue JBrowse link 8 22,757,722 22,782,848 RGD:6483827
G Plau plasminogen activator, urokinase JBrowse link 14 20,836,662 20,843,388 RGD:6483827
RGD:7241585
G Pmp22 peripheral myelin protein 22 JBrowse link 11 63,128,982 63,159,547 RGD:1358785
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha JBrowse link 5 51,454,249 52,116,058 RGD:7242051
G Ptafr platelet-activating factor receptor JBrowse link 4 132,564,067 132,582,683 RGD:9999207
G Ptn pleiotrophin JBrowse link 6 36,714,924 36,811,361 RGD:9831453
G Qars glutaminyl-tRNA synthetase JBrowse link 9 108,508,005 108,515,941 RGD:12910554
G Ran RAN, member RAS oncogene family JBrowse link 5 129,020,156 129,024,322 RGD:9835000
G Ranbp1 RAN binding protein 1 JBrowse link 16 18,239,979 18,248,694 RGD:9835000
G Rangap1 RAN GTPase activating protein 1 JBrowse link 15 81,704,248 81,730,798 RGD:9835000
G Rara retinoic acid receptor, alpha JBrowse link 11 98,927,813 98,974,942 RGD:11554173
G Rarb retinoic acid receptor, beta JBrowse link 14 16,430,839 17,082,331 RGD:11554173
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link 5 91,948,842 91,963,223 RGD:10045367
G Reg3b regenerating islet-derived 3 beta JBrowse link 6 78,370,885 78,373,466 RGD:9831430
G Rgma repulsive guidance molecule family member A JBrowse link 7 73,375,520 73,419,899 RGD:9850145
G Rpsa ribosomal protein SA JBrowse link 9 120,127,766 120,132,369 RGD:11041651
G Runx1 runt related transcription factor 1 JBrowse link 16 92,601,466 92,826,074 RGD:6482827
G Rxra retinoid X receptor alpha JBrowse link 2 27,676,445 27,763,319 RGD:11554173
G Scn10a sodium channel, voltage-gated, type X, alpha JBrowse link 9 119,608,456 119,719,322 RGD:6484251
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:11075075
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 JBrowse link 11 75,410,029 75,422,623 RGD:8554886
G Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 JBrowse link 7 45,163,921 45,176,139 RGD:9999206
G Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 JBrowse link 10 89,574,020 89,621,249 RGD:9999206
G Snw1 SNW domain containing 1 JBrowse link 12 87,449,910 87,472,299 RGD:11035242
G Sod1 superoxide dismutase 1, soluble JBrowse link 16 90,220,742 90,226,324 RGD:8655638
RGD:8655979
G Tlr2 toll-like receptor 2 JBrowse link 3 83,836,272 83,841,824 RGD:8553062
G Tlr4 toll-like receptor 4 JBrowse link 4 66,827,551 66,846,581 RGD:7364836
RGD:7815041
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:7364836
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a JBrowse link 6 125,349,723 125,362,483 RGD:5130898
RGD:5130963
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b JBrowse link 4 145,212,368 145,246,870 RGD:5130963
Sciatica term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 JBrowse link 19 44,139,246 44,146,470 RGD:2302154
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b JBrowse link 4 145,212,368 145,246,870 RGD:7245944

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12250
    disease of anatomical entity 11853
      nervous system disease 9292
        peripheral nervous system disease 1980
          mononeuropathy 135
            mononeuritis 134
              mononeuritis of lower limb 125
                lesion of sciatic nerve 125
                  sciatic neuropathy 122
                    Piriformis Muscle Syndrome + 0
                    Sciatica + 2
Path 2
Term Annotations click to browse term
  disease 12250
    disease of anatomical entity 11853
      nervous system disease 9292
        peripheral nervous system disease 1980
          neuropathy 1811
            mononeuropathy 135
              mononeuritis 134
                mononeuritis of lower limb 125
                  lesion of sciatic nerve 125
                    sciatic neuropathy 122
                      Piriformis Muscle Syndrome + 0
                      Sciatica + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.