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Term:Pick's disease
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Accession:DOID:11870 term browser browse the term
Definition:A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)
Synonyms:exact_synonym: Brain Atrophy, Circumscribed Lobar;   Circumscribed Lobar Atrophy of the Brain;   Dementia in Pick's disease;   Dementia with Lobar Atrophy and Neuronal Cytoplasmic Inclusions;   Lobar Atrophies (Brain);   Lobar Atrophy (Brain);   Lobar Atrophy Of Brain;   Lobar Atrophy of the Brain;   Pick Disease;   Pick Disease Of Brain;   Pick Disease of the Brain;   Picks Disease;   Picks Disease of Brain
 primary_id: MESH:D020774;   RDO:0000195
 alt_id: OMIM:172700
 xref: GARD:7392;   NCI:C85008
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Pick's disease term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:10047401
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:10047401
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:10047402
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:5509779
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:7495833
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:7240710
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:7240710
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:6480200
G Sncb synuclein, beta JBrowse link 17 10,384,472 10,392,776 RGD:6480200
G Tardbp TAR DNA binding protein JBrowse link 5 165,432,089 165,442,232 RGD:5687194

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        neurodegenerative disease 2691
          Pick's disease 10
Path 2
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        central nervous system disease 8092
          brain disease 7561
            disease of mental health 5514
              cognitive disorder 1843
                dementia 618
                  Frontotemporal Lobar Degeneration 38
                    frontotemporal dementia 33
                      Pick's disease 10
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.