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ONTOLOGY REPORT - ANNOTATIONS


Term:Lewy body dementia
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Accession:DOID:12217 term browser browse the term
Definition:A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER'S DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)
Synonyms:exact_synonym: DLB;   Dementia with Lewy bodies;   Diffuse Lewy Body Disease;   Lewy Body Type Senile Dementia;   Lewy body disease;   cortical Lewy body disease;   senile dementia of the Lewy body type
 narrow_synonym: DIFFUSE LEWY BODY DISEASE DIFFUSE LEWY BODY DISEASE WITH GAZE PALSY;   LEWY BODY VARIANT OF ALZHEIMER DISEASE;   LEWY BODY VARIANT OF ALZHEIMER'S DISEASE
 primary_id: MESH:D020961
 alt_id: OMIM:127750;   RDO:0004559
 xref: GARD:3243;   ICD10CM:G31.83;   ICD9CM:331.82;   NCI:C84826
For additional species annotation, visit the Alliance of Genome Resources.


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Lewy body dementia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGER advanced glycosylation end-product specific receptor JBrowse link 6 32,180,968 32,184,380 RGD:11554173
G AIF1 allograft inflammatory factor 1 JBrowse link 6 31,615,212 31,617,015 RGD:11554173
G ANXA5 annexin A5 JBrowse link 4 121,667,946 121,696,994 RGD:10053729
G APOE apolipoprotein E JBrowse link 19 44,905,796 44,909,395 RGD:7771591
G BECN1 beclin 1 JBrowse link 17 42,810,132 42,824,316 RGD:11554173
G CCR1 C-C motif chemokine receptor 1 JBrowse link 3 46,201,711 46,208,313 RGD:5688166
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 20 63,343,223 63,375,471 RGD:1358509
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 15 32,030,462 32,173,018 RGD:1358509
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:11554173
G ELK1 ETS transcription factor ELK1 JBrowse link X 47,635,520 47,650,604 RGD:7488914
G ENO2 enolase 2 JBrowse link 12 6,914,580 6,923,697 RGD:11554173
G GBA glucosylceramidase beta JBrowse link 1 155,234,452 155,244,627 RGD:5508424
RGD:12791014
RGD:7240710
RGD:11554173
RGD:8554872
G GFAP glial fibrillary acidic protein JBrowse link 17 44,903,159 44,915,552 RGD:11554173
G GPR37 G protein-coupled receptor 37 JBrowse link 7 124,743,885 124,765,792 RGD:13504666
G IGF1R insulin like growth factor 1 receptor JBrowse link 15 98,648,539 98,964,530 RGD:5129515
RGD:11554173
G IGF2 insulin like growth factor 2 JBrowse link 11 2,129,112 2,149,603 RGD:5129515
RGD:11554173
G IGF2R insulin like growth factor 2 receptor JBrowse link 6 159,969,099 160,111,504 RGD:11554173
G INS insulin JBrowse link 11 2,159,779 2,161,209 RGD:11554173
G INSR insulin receptor JBrowse link 19 7,112,257 7,294,414 RGD:11554173
G KLK6 kallikrein related peptidase 6 JBrowse link 19 50,958,631 50,969,598 RGD:1358597
G MAG myelin associated glycoprotein JBrowse link 19 35,292,086 35,313,807 RGD:11554173
G MAP2 microtubule associated protein 2 JBrowse link 2 209,424,047 209,734,118 RGD:6483091
RGD:11554173
G NGF nerve growth factor JBrowse link 1 115,285,915 115,338,253 RGD:11554173
G NGFR nerve growth factor receptor JBrowse link 17 49,495,293 49,515,008 RGD:10413896
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:1358529
G NTRK1 neurotrophic receptor tyrosine kinase 1 JBrowse link 1 156,815,750 156,881,850 RGD:11554173
G NTRK2 neurotrophic receptor tyrosine kinase 2 JBrowse link 9 84,668,458 85,027,070 RGD:11554173
G PCNA proliferating cell nuclear antigen JBrowse link 20 5,114,953 5,126,622 RGD:10448971
G PPARGC1A PPARG coactivator 1 alpha JBrowse link 4 23,792,021 24,472,905 RGD:11554173
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 6 161,347,417 162,727,802 RGD:10412737
G SEPTIN4 septin 4 JBrowse link 17 58,520,250 58,544,372 RGD:13504670
G SNCA synuclein alpha JBrowse link 4 89,724,099 89,838,324 RGD:6478704
RGD:8554872
RGD:13506723
RGD:11554173
RGD:7240710
RGD:6480103
RGD:6480095
RGD:6478792
G SNCB synuclein beta JBrowse link 5 176,620,082 176,630,561 RGD:6219004
RGD:7240710
RGD:8554872
RGD:6480095
RGD:6478800
G SNCG synuclein gamma JBrowse link 10 86,955,759 86,963,260 RGD:6478704
RGD:6480095
RGD:6478792
G SOD2 superoxide dismutase 2 JBrowse link 6 159,669,069 159,762,281 RGD:11554173
G TARDBP TAR DNA binding protein JBrowse link 1 11,012,654 11,030,528 RGD:5687180
G TH tyrosine hydroxylase JBrowse link 11 2,163,929 2,174,081 RGD:11554173
Parkinson's disease 4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SNCA synuclein alpha JBrowse link 4 89,724,099 89,838,324 RGD:7240710

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16489
    Diseases of the Aged 1040
      dementia 630
        Lewy body dementia 37
          Autosomal Dominant Diffuse Lewy Body Disease 0
          Diffuse Lewy Body Disease with Gaze Palsy 0
          Parkinson's disease 4 1
Path 2
Term Annotations click to browse term
  disease 16489
    disease of anatomical entity 15414
      nervous system disease 11652
        central nervous system disease 9760
          brain disease 9034
            disease of mental health 6953
              cognitive disorder 2323
                dementia 630
                  Lewy body dementia 37
                    Autosomal Dominant Diffuse Lewy Body Disease 0
                    Diffuse Lewy Body Disease with Gaze Palsy 0
                    Parkinson's disease 4 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.